Most significant health risk

FDA resources are used most effectively and efficiently to address the most significant health risks. 

From occupational studies it has been shown that the most significant health risk from Pt exposure is sensitization of the airways caused by soluble Pt compounds (Rosner and Merget 2000). Thus, for an assessment of the health effects of Pt it seems reasonable to distinguish between elemental Pt and halogenated Pt compounds. Pt is emitted from catalytic exhaust gas converters of cars in amounts which are in the ng km range, mainly as elemental Pt. The nanocrystalline Pt particles are attached to jm-sized aluminum oxide particles. Only very limited data are available from current studies showing that ultra-... 

Recently, attention has focused on the potential hazardous effects of certain chemicals on the endocrine system because of the abihty of these chemicals to mimic or block endogenous hormones, or otherwise interfere with the normal function of the endocrine system. Chemicals with this type of activity are most commonly referred to as endocrine disruptors. Some scientists believe that chemicals with the ability to disrupt the endocrine system are a potential threat to the health of humans, aquatic animals, and wildlife. Others believe that endocrine disrupting chemicals do not pose a significant health risk, particularly in light of the fact that hormone mimics exist in the natural environment. Examples of natural hormone mimics are the isoflavinoid phytoestrogens (Adlercreutz 1995 Livingston 1978 Mayr et al. 1992). 

Insecticide, used mostly to protect from diseases spread by insects. Also a byproduct in the production of dicofol, another insecticide. Limited use allowed under the Stockholm convention for areas where malaria is a significant health risk and economic constraints prevent the use of other pesticides... 

Exposure of the general population to fuel oils is most likely to occur as a result of the use of kerosene and other fuel oils in heaters, furnaces, and combustion engines. Spills of number 2 fuel oil in residential basements can pose a significant health risk a spill of 21 gallons would present a risk for 8 days or longer (Kaplan et al. 1993). Unintentional exposure to fuel oils may occur as a result of groundwater contamination from spilled fuel oils or contact with soils that have been contaminated with fuel oils. 

Because of a 1973 U.S. law requiring that mattresses meet requirements for cigarette-ignition resistance, it s hard to find a healthy mattress without the fire-retardant chemicals that pose significant health risks. A report by Environment California Research and Policy Center says that some of the most commonly used fire-retardant compounds are PBDEs, which have recently been accumu-... 

Although the intent of preparation of medicines is to benefit patients, the substances used may present occupational hazards to the operators preparing these medicines. Pharmacists, nurses, doctors and others who prepare, handle and administer these medicines may be exposed to significant health risks during their work. The greatest risk is for the operators, but people in adjacent work areas (e.g. clerical workers, support staff, maintenance personnel, and visitors) may also be at risk from exposure by inhalation of aerosols or by contact with contaminated surfaces and floors. Pharmacists may be expected to be the professionals who should know most about this topic, but consultation of an occupational health speciahst is necessary as well. 

Human obesity has been declared to be one of the most significant health problems in modern times with over 500 million people being overweight. Obesity is associated with an increased risk of developing several serious diseases including hypertension, coronary heart disease, type II diabetes, stroke, osteoarthritis, and cancer. Obesity increases the likelihood of mortality by 20% and recently surpassed smoking as the munber one cause of death [147,148]. 

The most significant issue with the fielding of a neutron-based explosive detection technology is pubfic perception. Most people have difficulty putting into perspective low probabihty high consequence events. This has resulted in the word nuclear being associated with health risks and environmental issues even when detailed analysis shows that there is no issue. 

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