Montelukast

L. Liu, H. Cheng, J. J. Zhao and J. D. Rogers, Determination of montelukast (MK-0476) and its 5-enantiomer in human plasma by stereoselective high performance liquid cliromatography with column-switching , ]. Pharm. Biomed. Anal. 15 631-638 (1997). [Pg.133]

Leukotrienes are rapidly produced and released during a Type I reaction (Fig. 3). They are responsible for a massive bronchoconstriction in allergic bronchial asthma and attract leukocytes, thus being proinflamma-tory. Consequently, antagonists of the LTC recqDtor have been proven useful in the therapy of bronchial asthma, often in combination with bronchodilators (example montelukast). [Pg.61]

Leukotriene receptor antagonists include montelukast sodium (Sngulair) and zafirlukast (Accolate). Zileuton (Zyflo) is classified as a leukotriene formation inhibitor. Additional information concerning these drags is found in the Summary Drag Table Antiasthma Drugs. [Pg.338]

Leuko trienes are bronchoconstrictive substances released by the body during the inflammatory process. When leukotriene production is inhibited, bronchodilation is facilitated. Zileuton acts by decreasing tire formation of leukotrienes. Although the result is tire same, montelukast and zafirlukast work in a manner slightly differently from that of zileuton. Montelukast and zafirlukast are considered leukotriene receptor antagonists because they inhibit leukotriene receptor sites in the respiratory tract, preventing airway edema and facilitating bronchodilation. [Pg.338]

Zafirlukast and zileuton are used in the prophylaxis and treatment of chronic asthma in adults and children older than 12 years. Montelukast is used in the prophylaxis and treatment of chronic asthma in adults and in children older than 2 years. [Pg.338]

Adverse reactions of zafirlukast (Accolate) include headache, dizziness, myalgia, pain, nausea, diarrhea, abdominal pain, vomiting, and fever. Montelukast (Singulair) administration may cause headache, dizziness, dyspepsia, flu-like symptoms, cough, abdominal pain, and fatigue Adverse reactions seen with the... [Pg.338]

These dru are contraindicated in patients with a known hypersensitivity to the dragp. Montelukast, zaflrlukast, and zileuton are not used in the reversal of bronchospasm in acute asthma attacks. Zileuton is con-... [Pg.340]

Administration of zafirlukast and aspirin increases plasma levels of zafirlukast, When zafirlukast is administered with warfarin, there is an increased effect of the anti coagulant. Administration of zafirlukast and theophylline or erythromycin may result in a decreased level of zafirlukast. Administration of montelukast with other drugs has not revealed any adverse responses. Administration of montelukast with aspirin and NSAIDs is avoided in patients with known aspirin sensitivity. Administration of zileuton with propranolol increases the activity or the propranolol with theophylline increases serum theophylline levels and with warfarin may increase prothrombin time (PT). A prothrombin blood test should be done regularly in the event dosages of warfarin need to be decreased. [Pg.340]

Montelukast—Take once daily in the evening, even when free of symptoms. Contact physician if the asthma is not well controlled. This drug is not for the treatment of an acute attack. Avoid taking aspirin and the NSAIDs while taking montelukast. [Pg.349]

Discuss what to include in a teaching plan for a patient taking montelukast for asthma. [Pg.349]

C24H30O5) see lloprost 17P-benzoyloxy-3p-hydroxy-5-androstene (C2ijH3403 1175-12-8) see Mesterolone Testosterone 2-[l-(benzoyloxymethyl)cyclopropyl]acetonitrile (C13H13NO2 142148-12-7) see Montelukast sodium... [Pg.2303]

QHi5ClSi 18162-48-6) see Caldpotriol Montelukast sodium Orlistat Simvastatin Tacrolimus (S)-4-(tert-butyldimethylsilyloxy)-2-hydroxybutyl 2-naph-thalenesulfonate... [Pg.2319]

C2oH fiClNO 149968-10-5) see Montelukast sodium [tx5-( )]-3-[2-(7-chloro-2-quinolinyl)ethenyl]-a-[2-[2-(l-methyl-l-[(tetrahydro-2//-pyran-2-yl)oxy]ethyl]phenyll-ethyl]benzenemethanol methanesulfonate (ester) (CjjHjgClNOjS 162489-71-6) see Montelukast sodium (5)-a-[3-[(E)-2-(7-chloro-2-quinolinyI)ethenyl]phenyl]-2-(l-hydroxy-l-methylethyl)benzenepropanol (C2i,H2xClN02) see Montelukast sodium (5)-a-[3-[( )-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-2-(l-hydroxy-l-methylethyl)benzenepropanol methanesulfonate... [Pg.2336]

C5HRO 110-87-2) see Dinoprost Dolasetron mesilate Flomoxef Iloprost Misoprostol Montelukast sodium Orlistat Pirarubicin Saquinavir... [Pg.2356]

S,7-dioxa-6-thiaspiro[2.5]octane 6-oxide (C HgOgS 89729-09-9) see Montelukast sodium... [Pg.2367]

C2jH3 07 67212-74-2) see Alclometasone dipropionate 2 -hydroxy-4 -(3-methyl-2-butenyloxy)acetophenone (C,3H] 03 24672-83-1) see Sofalcone 2-hydroxy-2-methylbutyric acid ethyl ester (C7H14O3 77-70-3) see Paramethadione 2-hydroxy-2-methylbutyronitrile (Ci H NO 4111-08-4) see Paramethadione 5(R)-(hydroxymethyl)-2-cyclopenten-l(R)-ol (C(jH,(,02 143395-28-2) see Abacavir 2-[l-(hydroxymethyl)cyclopropyl]acctonitrile (QH9NO 152922-71-9) see Montelukast sodium ( )-cis-2-hydroxymethyl-Af,Af-diethyl-l-phenylcyclo-propanecarboxamide... [Pg.2397]

CgH 02 626-19-7) see Montelukast sodium isophthaloyl chloride (C8H4CI2O2, 99-63-8) see Ditophal isophytol... [Pg.2403]

CNNa 143-33-9) see Alclofenac Alpidem Amphetaminil Atorvastatin calcium Azatadine Calcium pantothenate Carnitine Clopidogrel hydrogensulfate Clortermine Dexrazoxane Diclofenac Diloxanide Edetic acid Epinastine hydrochloride Ethosuximide Ethotoin Fenoprofen Ibuprofen Irbesartan Ketoprofen Lonazolac Mephenytoin Mepindolol Montelukast sodium Nabilone Oxymetazoline Paramethadione Pentorex Saquinavir Suprofen Thiamphenicol Tolmetin Trimazosin Zolpidem sodium cyanoborohydride... [Pg.2441]

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