Molecularly imprinted polymers characterics

Garcia-Calzon JA, Diaz-Garcia ME. Characterization of binding sites in molecularly imprinted polymers. Sens ActuatB 2007 123 1180-1194. 

Rampey AM, Umpleby RJ, Rushton GT, Iseman JC, Shah RN, Shimizu KD. Characterization of the imprint effect and the influence of imprinting conditions on affinity, capacity, and heterogeneity in molecularly imprinted polymers using the Freundlich isotherm-affinity distribution analysis. Anal Chem 2004 76 1123-1133. 

Umpleby II RJ, Baxter SC, Chen Y, Shah RN, Shimizu KD. Characterization of molecularly imprinted polymers with the Langmuir-Freundlich isotherm. Anal Chem 2001 73 4584-4591. 

Toth B et al (2006) Nonlinear adsorption isotherm as a tool for understanding and characterizing molecularly imprinted polymers. J Chromatogr A 1119(1—2) 29—33... 

Synthetic polymer spheres with the ability for molecular recognition represent a promising alternative to affinity binding matrices using biological molecules. This chapter describes various methods for the preparation of molecularly imprinted polymer spheres in the colloidal state. The synthesis, characterization, and performance of colloidal dispersions of molecularly imprinted polymer spheres and their application are discussed. 

In this chapter we describe various methods for preparing molecularly imprinted polymers (MIP) in a colloidal state. The resulting materials consist of submicron scale particles dispersed in a liquid acting as fully functional synthetic affinity receptors. The synthesis, characterization, and performance of colloidal molecularly imprinted polymers are described and applications with this new class of affinity receptors is discussed. 

Abstract Artificial receptors have been in use for several decades as sensor elements, in affinity separation, and as models for investigation of molecular recognition. Although there have been numerous publications on the use of molecular modeling in characterization of their affinity and selectivity, very few attempts have been made on the application of molecular modeling in computational design of synthetic receptors. This chapter discusses recent successes in the use of computational design for the development of one particular branch of synthetic receptors - molecularly imprinted polymers. 

Sellergren, B. Hall, A.J. Fundamental aspects on the synthesis and characterization of imprinted network polymers. In Molecularly Imprinted Polymers. Elsevier Amsterdam, the Netherlands, 2001 p. 21. 

Uezu, K. Tazume, N. Yoshida, M. Goto, M. Furusaki, S. Characterization and control of matrix for surface molecular-imprinted polymer. Kagaku Ronbunshi 2001, 27, 753-755. 

Umpleby II, R.J. Baxter, S.C. Bode, M. Berch, J.K. Shah, R.N. Shimizu, K.D. Application of the Freundlich adsorption isotherm in the characterization of molecularly imprinted polymers. Anal. Chim. Acta 2001, 435, 35-42. 

Baggiani, C. Giraudi, G. Giovannoli, C. Trotta, F. Vanni, A. Chromatographic characterization of a molecularly imprinted polymer binding the herbicide 2,4,5-trichloro-phenoxyacetic acid. J. Chromatogr. A. 2000, 883, 119-126. 

Muldoon, M.T. Stanker, L.H. Polymer synthesis and characterization of a molecularly imprinted sorbent assay for atrazine. J. Agric. Food Chem. 1995, 43, 1424-1427. Siemann, M. Andersson, L.I. Mosbach, K. Selective recognition of the herbicide atrazine by noncovalent molecularly imprinted polymers. J. Agric. Food Chem. 1996, 44, 141-145. 

Synthesis and Spectroscopic Characterization of Molecularly Imprinted Polymer Phosphonate Sensors, Chapter 2... 

Molecularly imprinted polymers (MIPs) that are capable of sensing specific organophosphorus compounds, such as pinacolyl methylphosphonate (PMP), by luminescence have been synthesized and characterized. The polymers have been synthesized using conventional free radical polymerization and using Reversible Addition Fragmentation Transfer (RAFT) polymerization. The RAFT polymers exhibited many advantages over conventional free radical processes but are more difficult to make porous. 

Takeuchi and co-workers (18) coupled combinatorial techniques with molecular imprinted polymers to develop sensors for triazine herbicides. The library consisted of a 7 x 7 array containing different fractions of monomers methacrylic acid (MAA) and 2-(trifluoromethyl)acrylic acid (TFMAA) with constant concentrations of the imprint molecules ametryn or atrazine. After UV-initiated polymerization, the products from the sensor library were characterized by HPLC measurement of herbicide concentration. The receptor efficiency was observed to vary with monomer type the atrazine receptor efficiency increased with MAA composition and the ametryn receptor was enhanced by increased fractions of TFMAA. Although only monomer concentration was varied in the hbraries, the authors conclude that the CM synthetic approach would be usefiil in analyzing other variables such as solvent, cross-linking agent, and polymerization conditions to produce optimum molecularly imprinted polymer sensors. 

Belfer S, Fainchtain R, Purinson Y, Kedem O (2000) Surface characterization by FTIR-ATR spectroscopy of polyether-sulfone membranes - unmodified, modified and protein fouled. J Membr Sci 172 113-124 Bergmann NM, Peppas NA (2008) Molecularly imprinted polymers with specific recognition for macromolecules and proteins. Prog Polym Sci 33 271-288... 

Spivak, D.A. (2005). Optimization, evaluation, and characterization of molecularly imprinted polymers. Advanced Drug Delivery Reoiws, 57,1779-1794. 

Figure 8.8 Schematic illustration of the fabrication procedure for the molecular imprinted polymer (MIP) and cyclic voltammetry curves comparing imprinted and non-imprinted (NIP) electrodes characterized using 1 mM [Fe(CN)6] . (Reproduced from ref. 60 with the permission of Elsevier.)...

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