Model patient

Uehing MD. Model patient. Bio-IT World, November 1, 2005, http //www.bio-itworld.com/archive/121503/trials.html... 

The effect of this subtle difference in device function can be seen when the measured signal in the presence of biofouling is modeled. As a model patient, we considered the transient response of an individual with basal insulin provided after each of the three daily meals. Blood glucose dynamics predicted by Sorensen was corrected for diffusion to subcutaneous tissue using the mass transport model of Schmidtke et al.24 25 Figure 11.1 shows a model comparison between the sensor response of an electrochemical sensor and an optical sensor with an assumed... 

Information systems are often described in terms of the entities about which they manage information, the attributes that describe those entities, and the relationships between the entities. This approach to modeling the information is called entity-relationship modeling or E-R modeling. Patients, providers, specimens, and orders are examples of entities, and medical record number, provider identifier, accession number, and order number are all examples of attributes. The relationship between these entities is represented by a data structure that includes a particular patient identifica-... 

Wenninger K, Kehrt R, von Ruden U, Lehmann C, Binder C, Wahn U, Staab D Structured parent education in the management of childhood atopic dermatitis The Berlin model. Patient Educ Couns 2000 40 253-261. 

It was clear that having information about the patient s DNA on the record could one day be vital to the selection of the correct drugs, for example, using the Blue Gene supercomputer to model patient protein-drug interactions in atomic detail. A demonstration was possible in 2000 on a much slower com-... 

Despite the differences with respect to the desired serum concentration goals, evaluation of aminoglycoside levels and pharmacokinetic adjustment of dosing regimens are common to both approaches. Using a first-order pharmacokinetic model, patient-specific elimination and volume of distribution can be calculated based on... 

Fig. 4 Using Human Pluripotent Stem Cells for Disease Modeling. Patient-specific somatic cells (e.g. skin fibroblasts) can be reprogrammed into induced pluripotent stem cells (iPSCs) using specific genetic factors. Neuronal cells with specific disease phenotypes can be differentiated to neural stem cells. The development of in vitro cellular models based on patient-specific cells may lead to personalized medicine approaches with minimal side effects and improved pharmacological efficacy.

Statistical survival models are a well known approach for modeling patient survival statistics (Kaplan and Meier, 1958). In recent years, statistical survival models have been applied in risk and reliability. The Kaplan Meier statistical survival model is usually applied with reference to time. In AUV operation management the science manager interest is to assess the chances of AUV survival with range. A simple modification to the Kaplan-Meier approach is necessary in order to capture this requirement (Brito, et al., 2008). 

The hospital staff will provide the diagnostic equipment and services (e.g., magnetic resonance imaging [MRI]), CAT scan, computer modelling, patient selection) and all other medical services (e.g., patient transportation). 

Thiazolidinediones (PPARy-agonists) Thiazolidine-diones ( pioglitazone, rosiglitazone) lower blood glucose levels in animal models of insulin resistance and also in insulin resistant patients. They are agonists of the peroxisome proliferator-activated receptor y (PPARy). Because they enhance the effect of insulin and reduce serum insulin levels in insulin resistant patients, thiazolidinediones are usually referred to as insulin sensitizers . 

Parkinson s disease (PD) 1. In a non-human primate model of PD endocannabinoid levels are elevated in the basal ganglia and may contribute to the generation of parkinsonian symptoms and/or to expression of levodopa-induced dyskinesia. The cerebrospinal fluid of untreated PD patients contains elevated levels of AEA 1. CB-) antagonists or biosynthesis inhibitors... 

Colon inflammation 1. AEA levels are elevated in the colon of DNBS-treated mice and in the colon submucosa of TNBS-treated rats, two animal models of inflammatory bowel diseases, and in the biopsies of patients with ulcerative colitis, to control inflammation 1. Inhibitors of degradation (both FAAH and cellular re-uptake)... 

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