Ministry of Health, Labour and Welfare Japan

Ministry of Health, Labour and Welfare, Japan (2000) Guide to concentration of volatile chemicals in room. 

In Japan, bifenox is the only registered diphenyl ether herbicide. The tolerance and/or maximum residue limits (MRLs) are established at 0.1 mg kg for cereals such as rice grain, barley and wheat, and 0.05mgkg for potatoes (Ministry of Health, Labour and Welfare, Japan). Ibe California Department of Food and Agriculture (CDFA) established the minimum detectable quantity of diphenyl ether herbicides at 0.1 mgkg for bifenox, nitrofen and oxyfluorfen. ... 

International Association of Pharmaceutical Companies (the Czech Republic) Ministry of Health Labour and Welfare (Japan)... 

JECDB Database of chemical toxicity provided by Ministry of Health, Labour and Welfare, Japan. It contains reports of toxicological tests of compounds in the environment http //dra4.nihs.go.jp/mhlw data/jsp/SearchPageENG.jsp... 

Notification No. 1106001 of November 6, 2002, and the revised Notification No. 0622003 of June 22, 2006, Department of Food Safety, the Ministry of Health, Labour and Welfare of Japan. 

The Ministry of Health, Labour and Welfare is the governmental body responsible for enacting legislation for pharmaceutical affairs. The regulation of clinical trials and new drug approval in Japan is based on the Pharmaceutical Affairs Law and related ordinances. The objective of the Ministry is to secure a safe medical environment through a consolidated structure of accurate reviews of pharmaceuticals and medical devices and postmarketing safety measure implementation. 

The research was supported in part by the Health and Labour Sciences Research Grants for Research on Advanced Medical Technology from The Ministry of Health, Labour and Welfare of Japan. We thank the Japan Association for the Advancement of Medical Equipment for supporting the Postdoctoral Fellowship for Dr. Jose Mario Barichello. 

This novel drug was officially approved for clinical use in January 2009 by the Ministry of Health, Labour, and Welfare of Japan. This is the first pharmaceutical success ever achieved for a selective opioid k agonist. All the other compounds derived from modifications of U-50,488H have been withdrawn or halted in early clinical phase development. Furthermore, nalfurafine hydrochloride is recognized as the first nonnarcotic opioid drug in history. 

MHLW (Ministry of Health, Labour and Welfare). 2005. Enforcement regulation for the law on special measures against Bovine Spongiform Encephalopathy under jurisdiction of the Ministry of Health, Labour and Welfare. Ministry of Health, Labour and Welfare Ordinance No. 110, Article 2. Tokyo, Japan. 

In Japan, the Positive List system was implemented on May 29, 2006. The Japanese Ministry of Health, Labour, and Welfare had established many provisional maximum residue limits (MRLs) in addition to present MRLs, and 586 pesticides were regulated under the Food Sanitation Law [1]. A uniform level of 0.01 ppm is established as the level having no potential to cause damage to human health [2], A rapid and sensitive multiresidue analytical method was required to conduct efficient and effective monitoring surveys of pesticide residues to ensure food safety. 

The six parties that are the founding members of ICH and directly involved in the decision-making process represent the regulatory bodies and the research-based industry in the European Union, Japan, and the USA, the three regions where the majority of new drugs are developed. They are the Committee for Proprietary Medicinal Products of the European Agency for the Evaluation of Medicinal Products and the European Federation of Pharmaceutical Industries and Associations in the EU, the Ministry of Health, Labour and Welfare and Japan Pharmaceutical Manufacturers Association in Japan, the Food and Drug Administration and Pharmaceutical Research and Manufacturers of America in the USA. 

Directive. In the USA, the legal responsibility rests with the FDA. In Japan, the Ministry of Health, Labour and Welfare regulates the safety of hair dyes, considering them as quasi-drugs , subject to approval based on evidence of their safety, and there are similar regulations in other Far Eastern countries. 

The Pharmaceutical and Medical Safety Bureau (PMSB) has primary responsibility within the Japanese Ministry of Health, Labour and Welfare for administering the requirements established for the safety and efficacy of medical products under Japan s Pharmaceutical Affairs Law. This legislation was substantially amended in 1996 (with the reforms made effective in April 1997) to provide for the present medical product review and approval system. 

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