Microwave organic synthesis

Keywords Heterocycles Multicomponent reactions Microwave Organic synthesis... [Pg.32]

It is possible to carry out a number of microwave organic synthesis. These syntheses are grouped in the following three categories ... [Pg.60]

Lukasik N, Wagner-Wysiecka E (2014) A review of amide bond fmmation in microwave organic synthesis. Curr Otg Synth ll(4) 592-604... [Pg.56]

Appiication of commerciai microwave ovens to organic synthesis [103]... [Pg.196]

Majetich G., Hicks R. Applications of Microwave-Accelerated Organic Synthesis... [Pg.316]

In the 1990s the technique of solid-phase organic synthesis (SPOS) became generally popular, but especially in the medicinal chemistry community, for lead detection and lead optimization via combinatorial techniques. The combination with microwave irradiation brought an elegant solution for the problem of the notoriously slower reactions compared to those in solution phase. [Pg.12]

This chapter has taken the reader through a number of microwave-assisted methodologies to prepare and further functionalize 2-pyridone containing heterocycles. A survey of inter-, intramolecular-, and pericyclic reactions together with electrophilic, nucleophilic and transition metal mediated methodologies has been exemplified. Still, a number of methods remain to be advanced into microwave-assisted organic synthesis and we hope that the smorgasbord of reactions presented in this chapter will inspire to more successful research in this area. [Pg.27]

Loupy A (ed) (2002) Microwaves in organic synthesis. WUey, Weinheim... [Pg.56]

In recent years, parallel to the emergence of SPOS, microwave-mediated organic synthesis has come to hght and has developed into a popular field [24-31]. The main advantage of microwave dielectric heating compared to other conventional methods, such as hot plate, oil bath or isomantle, is the tremendous rate enhancement generally observed under microwave irradiation conditions. Various theories have been proposed to explain the source of the rapidity of microwave chemistry [32,33]. However, the gener-... [Pg.82]

Linear non-cross-linked polystyrene has been used for organic synthesis since it is readily soluble in common organic solvents (i.e., dichloromethane, chloroform, tetrahydrofuran, toluene, ethyl acetate, and pyridine) but precipitates upon addition of water or methanol [123-126]. However, no examples of the use of this polymer in conjunction with microwave chemistry have been reported. [Pg.87]

Fig. 8 Modified Smith process vial for microwave-assisted solid-phase organic synthesis...

Tierney JP, Lidstroem P (eds) Microwave assisted organic synthesis. Blackwell Publishing Ltd, Oxford, UK... [Pg.152]

Swamy KMK, Yeh W-B, Lin M-J, Sun C-M (2003) Curr Med Chem 10 2403 CarUlo JR, Dfaz-Ortiz A, de la Hoz A, Moreno A, Gomez MV, Prieto P, Sanchez-Migalldn A, Vazquez E (2003) In Attanasi OA, Spinelli D (eds) Targets in heterocyclic systems, chemistry and properties. Italian Society of Chemistry, vol 7 Baxendale IR, Lee A-L, Ley SV (2005) In Tierney JP, Lidstrom P (eds) Microwave assisted organic synthesis, chap 6. Blackwell Publishing Ltd, Oxford, UK Kappe CO, Stadler A (2005) Microwaves in organic and medicinal chemistry, chap 7. Wiley, Weinheim... [Pg.153]

Keywords Copper MAOS (Microwave assisted organic synthesis) Nickel Palladium Transition-metal-mediated bond formation... [Pg.155]

LindstrOm P, Tierney JP (eds) (2005) Microwave-assisted organic synthesis. Black-well, Oxford... [Pg.209]

An additional interest in the appUcations of microwave-assisted organic synthesis is related to the possibility of having more rapid access to large libraries of diverse small molecules and heterocycUc compounds... [Pg.214]

Except for a few examples, all the reactions reported herein have been carried out under controlled microwave heating using dedicated instruments for organic synthesis that register the temperature and pressure of the reaction mixture, giving more reproducible results and allowing to work under safe conditions. [Pg.215]

The application of microwaves to organic synthesis has been the subject of several books [ 13-16] and review articles [ 17-25] where the principles of the technique have been described. [Pg.215]

HMPB 4-Hydroxymethyl-3-methoxyphenoxybutyric acid MAOS Microwave-assisted organic synthesis NBS AT-Bromosuccinimide NIS AT-Iodosuccinimide PIPE Poly(tetrafluroethylene)... [Pg.268]

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