Microwave-assisted Organic Syntheses MAOS

Due to the importance of substituted 2-pyridones, many preparative methods have been reported (see Sect. 2.1), and some of these, but for from all, have been further developed into methods suitable for microwave-assisted organic synthesis (MAOS). Here we describe mainly methods performed with instruments specially designed for MAOS, thus excluding synthesis per-... 

Microwave-Assisted Organic Synthesis (MAOS) - A Brief History... 

For online resources on microwave-assisted organic synthesis (MAOS), see uwiv.maos.net. 

In modern microwave synthesis, a variety of different processing techniques can be utilized, aided by the availability of diverse types of dedicated microwave reactors. While in the past much interest was focused on, for example, solvent-free reactions under open-vessel conditions [1], it appears that nowadays most of the published examples in the area of controlled microwave-assisted organic synthesis (MAOS) involve the use of organic solvents under sealed-vessel conditions [2] (see Chapters 6 and 7). Despite this fact, a brief summary of alternative processing techniques is presented in the following sections. 

The total synthesis of a high affinity TSPO (translocator protein) ligands, DPA-714 (ix), starting from 3-(4-methoxyphenyl)-3-oxopropanenitrile (vii) and 2-chloro-N,N-diethylacetamide (viii) utilizing the microwave assisted organic synthesis (MAOS) has been described by Tang et al. [16]. 

Abstract 2-pyridones are important heterocydes with great applicability in medicinal chemistry and this core structure can be found in compounds with various biological/medicinal applications. Here we show how microwave-assisted chemistry can be used to effectively synthesize and functionalize substituted monocydic 2-pyridones, 2-quinolones and other ring-fused 2-pyridones. The chapter covers recent advancements in this field mainly describing methods developed with instruments specially designed for microwave-assisted organic synthesis (MAOS). 

---