Organic synthesis, microwave-assiste

In this chapter we discuss the new speeding-up techniques, optimized during the last decade, such as solid-phase extraction, polymer-assisted solution-phase synthesis, microwave-assisted organic synthesis, and flow chemistry. The improvements obtained with these techniques are not limited to a subset of chemical reactions (e.g., the reported examples), but they are fully applicable to the entire set of chemistry involved in the synthetic drug discovery process. [Pg.356]

MICROWAVE-ASSISTED ORGANIC SYNTHESIS Microwaves and Their Heating Effect... [Pg.831]

As in other areas of organic synthesis, microwave irradiation has been adapted in Fischer indolizations (Table 3) [70-77], Whereas montmorillonite KSF worked well as reported for entries 1 to 3 [70], it utterly failed as reported for entries 4 to 5 [71], Entry 9 represents a novel decarboxylation of indole-2-carboxylic acids during microwave heating [73], For entries 10 and 11, yields are invariably higher under microwave conditions than with conventional heating, and the former represents an excellent synthesis of y-carbolines [74], Entries 12 to 15 feature propyl phospho-nic acid cyclic anhydride (T3P) as a mild water scavenger [75], Kremsner and Kappe have studied microwave-assisted organic synthesis in near-critical water at 300 °C,... [Pg.41]

This chapter has taken the reader through a number of microwave-assisted methodologies to prepare and further functionalize 2-pyridone containing heterocycles. A survey of inter-, intramolecular-, and pericyclic reactions together with electrophilic, nucleophilic and transition metal mediated methodologies has been exemplified. Still, a number of methods remain to be advanced into microwave-assisted organic synthesis and we hope that the smorgasbord of reactions presented in this chapter will inspire to more successful research in this area. [Pg.27]

Kappe CO, Stadler A (2002) Microwave-assisted combinatorial chemistry. In Loupy A (ed) Microwaves in organic synthesis. Whey, Weinheim... [Pg.57]

Fig. 8 Modified Smith process vial for microwave-assisted solid-phase organic synthesis...

Tierney JP, Lidstroem P (eds) Microwave assisted organic synthesis. Blackwell Publishing Ltd, Oxford, UK... [Pg.152]

Swamy KMK, Yeh W-B, Lin M-J, Sun C-M (2003) Curr Med Chem 10 2403 CarUlo JR, Dfaz-Ortiz A, de la Hoz A, Moreno A, Gomez MV, Prieto P, Sanchez-Migalldn A, Vazquez E (2003) In Attanasi OA, Spinelli D (eds) Targets in heterocyclic systems, chemistry and properties. Italian Society of Chemistry, vol 7 Baxendale IR, Lee A-L, Ley SV (2005) In Tierney JP, Lidstrom P (eds) Microwave assisted organic synthesis, chap 6. Blackwell Publishing Ltd, Oxford, UK Kappe CO, Stadler A (2005) Microwaves in organic and medicinal chemistry, chap 7. Wiley, Weinheim... [Pg.153]

Keywords Copper MAOS (Microwave assisted organic synthesis) Nickel Palladium Transition-metal-mediated bond formation... [Pg.155]

LindstrOm P, Tierney JP (eds) (2005) Microwave-assisted organic synthesis. Black-well, Oxford... [Pg.209]

An additional interest in the appUcations of microwave-assisted organic synthesis is related to the possibility of having more rapid access to large libraries of diverse small molecules and heterocycUc compounds... [Pg.214]

HMPB 4-Hydroxymethyl-3-methoxyphenoxybutyric acid MAOS Microwave-assisted organic synthesis NBS AT-Bromosuccinimide NIS AT-Iodosuccinimide PIPE Poly(tetrafluroethylene)... [Pg.268]

Due to the importance of substituted 2-pyridones, many preparative methods have been reported (see Sect. 2.1), and some of these, but for from all, have been further developed into methods suitable for microwave-assisted organic synthesis (MAOS). Here we describe mainly methods performed with instruments specially designed for MAOS, thus excluding synthesis per-... [Pg.310]

Microwave technology has now matured into an established technique in laboratory-scale organic synthesis. In addition, the application of microwave heating in microreactors is currently being investigated in organic synthesis reactions [9-11] and heterogeneous catalysis [12, 13]. However, most examples of microwave-assisted chemistry published until now have been performed on a... [Pg.290]

P. Lindstrom, J. Tierney, B Wathey and J. Westerman, Microwave Assisted Organic Synthesis - A Review , Tetrahedron, 2001, 57, 9222. [Pg.234]

For recent reviews on microwave irradiation-assisted organic synthesis, see Kuhnert, N., Angew. Chem., hit. Ed. 2002, 41, 1863 Lidstrom, P Tierney, J., Wathey, B Westman, J., Tetrahedron 2001, 57, 9225. [Pg.142]

Komatsu K (2005) The Mechanochemical Solid-State Reaction of Fullerenes. 254 185-206 Kremsner JM, Stadler A, Kappe CO (2006) The Scale-Up of Microwave-Assisted Organic Synthesis. 266 233-278... [Pg.261]

For a review on microwave-assisted reactions in organic synthesis, see (a) S. Cad-dick, Tetrahedron 1995, 52, 10403-10432 ... [Pg.589]

Microwave-Assisted Organic Synthesis (MAOS) - A Brief History... [Pg.2]

Scheme 1.1 Hydrolysis of benzamide. The first published example (1986) of microwave-assisted organic synthesis.

Alternatively, microwave-assisted synthesis has been carried out using standard organic solvents under open-vessel conditions. If solvents are heated by microwave irradiation at atmospheric pressure in an open vessel, the boiling point of the solvent typically limits the reaction temperature that can be achieved. In order to none-... [Pg.3]

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