Organic Synthesis Using Microwaves and Supported Reagents

Organic Synthesis Using Microwaves and Supported Reagents 

Heterogeneous reactions facilitated by supported reagents on inorganic oxide surfaces have received attention in recent years, both in the laboratory and in industry. Although the first description of the surface-mediated chemical transformation dates back to 1924 [13], it was not until almost half a century later that this technique received extensive attention with the appearance of several reviews, books, and account articles [14-22]. 

A related development that has had profound effect on heterogeneous reactions is the use of microwave (MW) irradiation techniques for the acceleration of organic reactions. Since the appearance of initial reports on the application of microwaves for chemical synthesis in polar solvents [11], the approach has blossomed into a 

Microwaves in Organic Synthesis, Second edition. Edited by A. Loupy Copyright 2006 WILEY-VCH Veriag GmbH Co. KGaA, Weinheim ISBN 3-527-31452-0 

thus providing unique chemical processes with special attributes such as enhanced reaction rates, higher yields, improved purity of final products, and associated ease of manipulation. These reactions are performed with the reagents immobilized on the porous solid supports and have advantages over conventional solution-phase reactions, because of the good dispersion of active reagent sites, associated selectivity, and easier work-up. 

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I 6 Organic Synthesis Using Microwaves and Supported Reagents... 

I 8 Organic Synthesis Using Microwaves and Supported Reagents 8.2.4.4 Oxidations with Claycop-Hydrogen Peroxide... 

Varma, R. S. Ju, Y. Organic Synthesis Using Microwaves and Supported Reagents. In Microwaves in Organic Synthesis, 2nd ed. Loupy, A. Ed. Wiley-VCH Weinheim, Germany, 2006 Vol 1 Chap 8 pp 362-415. 

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