Methyltransferase cloning

Human Catechol-O-Methyltransferase Cloning and Expression of the Membrane-Associated Form." Proceedings of the National Academy of Sciences of the United States of America 88 1416-20. 

Szumlanski C, Otterness D, Her C et al. Thiopurine methyltransferase pharmacogenetics human gene cloning and characterization of a common polymorphism. DNA Cell Biol 1996 15 17— 30. 

FRICK, S., KUTCHAN, T.M., Molecular cloning and functional expression of O-methyltransferases common to isoquinoline alkaloid and phenylpropanoid biosynthesis, Plant J., 1999,17, 329-339. 

Okano, M., Xie, S. and Li, E. (1998) Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nature Genetics,... 

Bestor, T, Laudano, A., Mattaliano, R. and Ingram, V. (1988) Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. 

Takeshita, N., Fujisawa, H Miura, H Fitchen, J. H Yamada, Y. and Sato, F. 1995. Molecular cloning and characterization of S-adenosyl-L-methionine scoulerine-9-O-methyltransferase from cultured Coptis japonica cells. Plant Cell Physiology, 36 29-36. 

Uefuji, H., Ogita, S., Yamaguchi, Y Koizumi, N. and Sano, H. 2003. Molecular cloning and characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants. Plant Physiology, 132(1) 372-380. 

Morishige, T., Dubouzet, E., Choi, K. B., Yazaki, K. and Sato, F. 2002. Molecular cloning of columbamine O-methyltransferase from cultured Coptis japonica cells. European Journal of Biochemistry, 269(22) 5659-5667. 

Gauthier, A., Gulick, P.J., and Ibrahim, R.K., cDNA cloning and characterization of a 375 -0-methyltransferase for partially methylated fiavonols from Chrysosplenium americanum. Plant Mol Biol, 32, 1163, 1996. 

Muzac, I. et al.. Functional expression of an Arabidopsis cDNA clone encoding a fiavonol 3 -0-methyltransferase and characterization of the gene product. Arch. Biochem. Biophys., 375, 385, 2000. 

Schroder, G., Wehinger, E., and Schroder, J., Predicting the substrates of cloned plant 0-methyltransferases. Phytochemistry, 59, 1, 2002. 

Akashi, T. et al., cDNA cloning and biochemical characterization of S-adenosyl-L-methionine 2,7,4 -trihydroxyisoflavanone 4 -0-methyltransferase, a critical enzyme of the legume isofiavonoid phytoalexin pathway. Plant Cell Physiol, 44, 103, 2003. 

He, X.Z., Reddy, J.T., and Dixon, R.A., Stress responses in alfalfa (Medicago sativa L). XXII. cDNA cloning and characterization of an elicitor-inducible isofiavone 7-0-methyltransferase. Plant Mol Biol, 36, 43, 1998. 

Honchel R, Aksoy lA, Szumlanski C et al. Human thiopurine methyltransferase molecular cloning and expression of T84 colon carcinoma cell eDNA. Mol Pharmacol 1993 43 878-887. 

Lee D, Szumlanski C, Houtman J et al. Thiopurine methyltransferase pharmacogenetics cloning of human liver cDNA and a processed pseudogene on human chromosome 9>c(2l.l.DrugMetabDispos 1995 23 398 05. 

The general scheme of the biosynthesis of catecholamines was first postulated in 1939 (29) and finally confirmed in 1964 (Fig. 2) (30). Although not shown in Figure 2, in some cases the amino acid phenylalanine [63-91-2] can serve as a precursor it is converted in the liver to (-)-tyrosine [60-18-4] by the enzyme phenylalanine hydroxylase. Four enzymes are involved in E formation in the adrenal medulla and certain neurons in the brain tyrosine hydroxylase, dopa decarboxylase (also referred to as L-aromatic amino acid decarboxylase), dopamine-P-hydroxylase, and phenylethanolamine iV-methyltransferase. Neurons that form DA as their transmitter lack the last two of these enzymes, and sympathetic neurons and other neurons in the central nervous system that form NE as a transmitter do not contain phenylethanolamine N-methyl-transferase. The component enzymes and their properties involved in the formation of catecholamines have been purified to homogeneity and their properties examined. The human genes for tyrosine hydroxylase, dopamine- 3-oxidase and dopa decarboxylase, have been cloned (31,32). It is anticipated that further studies on the molecular structure and expression of these enzymes should yield interesting information about their regulation and function. 

Bout, S., and Vermerris, W., 2003, A candidate gene-approach to clone the sorghum Brown midrib gene encoding caffeic acid O-methyltransferase, Mol. Genet. Genomics 269 205-214. 

H Ikeda, LR Wang, T Ohta, J Inokoshi, S Omura. Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producing Streptomyces avermitilis. Gene 206 175-180, 1998. 

H Ogawa, K Konishi, Y Takata, HNakashima, M Fujioka. Rat glycine methyltransferase. Complete amino acid sequence deduced from a cDNA clone and characterization of the genomic DNA. Eur J Biochem 168 141-151, 1987. 

Yan L, Otterness DM, Kozak CA, Weinshilboum RM. Mouse nicotinamide N-methyltransferase gene molecular cloning, structural characterization, and chromosomal localization. DNA cell Biol. 1998 17(8) 639—667. 

Yang L, Xia L, Wu DY, Wang H, Chansky HA, Schubach WH, Hickstein DD, Zhang Y. Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. Oncogene 2002 21 148-152. 

CHIRON, H., DROUET, A, CLAUDOT, A.-C., ECKERSKORN, C.TROST, M., HELLER, W., ERNST, D SANDERMANN JR, H Molecular cloning and functional expression of a stess-induced multifunctional O-methyltransferase with pinosylvin methyltransferase activity from Scots pine (Pinus sylvestris L.). Plant Mol. Biol., 2000, 44, 735-745. 

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