Methylmercuric chloride

Methylmercuric chloride [115-09-3] M 251.1, m 167 . Crystd from absolute EtOH (20mL/g). 

Methylmercuric chloride (h/Jj 20-25), ethylmercuric chloride (h/ f 25-30), phenylmercuric chloride (h/ f 35-40), dimethylmercury (h/ f 65-70) and diphenylmer-cury (h/Jf 75-80) appeared as violet zones on a pale yellow to pale green background. 

Fig. 1 Reflectance scan of a chromatogram track with 30 ng substance (calculated as Hg) per chromatogram zone 1 = methylmercuric chloride, 2 = ethylmercuric chloride, 3 = phenyl-mercuric chloride, 4 = dimethylmercury, 5 = diphenylmercury.

The degradation of phenylmercuric acetate to benzene, methylmercuric chloride to methane, and ethylmercuric chloride to ethane and Hg + is apparently carried out by different enzymes from the plasmid-carrying Escherichia coli strain K12 (R831) (Schottel 1978) and Pseudomonas sp. Resistance to organic mercury compounds has also been found in clinical isolates of nontuber-culous, rapidly growing mycobacteria (Steingrube et al. 1991) and can present a challenge in the clinical environment. 

Rowland IR, Davies MJ, Grasso P. 1978. Metabolism of methylmercuric chloride by the gastro-intestinal flora of the rat. Xenobiotica 8 37-43. 

Christensen, G., E. Hunt, and J. Fiant. 1977. The effect of methylmercuric chloride, cadmium chloride and lead nitrate on six biochemical factors of the brook trout (Salvelinus fontinalis). Toxicol. Appl. Pharmacol. 42 523-530. 

Baatrup, E. and K.B. Doving. 1990. Flistochemical demonstration of mercury in the olfactory system of salmon (Salmo salar L.) following treatments with dietary methylmercuric chloride and dissolved mercuric chloride. Ecotoxicol. Environ. Safety 20 277-289. 

FIRST-ORDER RATE COEFFICIENTS, A°bs(seC ), FOR THE ACIDOLYSIS OF THE 4-PYRIDIO-METHYLMERCURIC CHLORIDE ION IN 0.01 M AQUEOUS PERCHLORIC ACID AND AT AN IONIC STRENGTH OF 0.51 A/, AT 65 °C13... 

In solvent DMSO, the rate of reaction (17) (R = Me, X = Cl) was too fast to follow, but using the mixture DMSO-dioxan (1 9 v/v) at 24.7 °C, rate coefficients for the substitution of the gold(I) complex by several alkylmercuric salts were obtained. It was found that in this mixed solvent, reaction (17) followed first-order kinetics, first-order in the gold(I) complex and zero-order in the alkylmercuric salt. Furthermore, the first-order rate coefficient had the same value no matter what alkylmercuric salt was used (methylmercuric acetate, methylmercuric chloride, methylmercuric bromide, and ethylmercuric chloride were the salts used). At 24.7 °C, the first-order rate coefficient has the value 0.0083 sec-1, with a standard deviation of 0.0006 sec-1. 

Roderer, G., 1983. Differential toxic effects of mercuric chloride and methylmercuric chloride on the freshwater alga Poterioochromonas malhamensis. Aqu. Toxicol., 3 23-34. 

Methotrexate, sodium (15475-56-6) Methylmercuric chloride (00115-09-3) Methylroercury chloride (00115-09-3) Methylmercury dicyandiamide (00502-39-6) Methylmercury hydroxide (01184-57-2)... 

Air Mercury Dimethyl and methylmercuric chloride GC/quartz T tube atomiser 2-5 ng Bzezinska ef a/. (1983)... 

The precision achieved in this method on Milli-Q water was 0.2% rsd at the 0.2ng L 1 methylmercuric chloride level and 1.56% rsd at the 2ng L 1 level. A detection limit of 0.24ng L 1 was achieved for a 50mL water sample. 

SYNS CASPAN CHLOROMETHYLMERCURY METHYLMERCURIC CHLORIDE METHYLMERCURY CHLORIDE MMC . MONOMETHYL. MERCURY CHLORIDE... 

This work was initiated in 1927, and in 1953 the last paper of the series was published. Intermittently, other related investigations were accomplished. Here, I would like to mention the reaction of aliphatic diazo compounds with mercuric chloride. The reaction of methylamine with mercuric chloride under the conditions of the diazo method was unsuccessful. Instead of the methylmercuric chloride expected, the synthesis gave negligible amounts of chloromethylmercury chloride, a compound obtained by Hellerman from mercuric dichloride and diazomethane in good yield. With diazoacetic ester, the compound (ClHg(Cl)y—C(=0)0C2H5 2Hg... 

Supercritical fluid extraction has proved suitable for separating organometallic compounds from solid matrices, as shown for methylmercuric chloride, which was quantitatively extracted from a cellulose-based matrix by neat CO, supplied with a small amount... 

There is inconclusive evidence that occupational exposure to metallic mercury and to organic and inorganic mercury compounds, primarily through inhalation, causes structural and numerical chromosome aberrations in human lymphocytes. In one study, significant increases in the frequency of acentric fragments (chromosome breaks) occurred in 4 workers exposed to high concentrations of metallic mercury and in 18 workers exposed to a mixture of mercuric chloride, methylmercuric chloride,... 

Methylmercury toxicity is very strain- and sex-specific in mice. A single oral dose of methylmercuric chloride at 16 mg Hg/kg resulted in the death of 4 of 6 male mice (C57BL/6N Jcl strain) but no deaths in females (Yasutake et al. 1991b). No increase in mortality was observed in female mice until 40 mg Hg/kg was administered, at which dosage 4 of 6 females died. Twenty-six weeks of dietary exposure to methylmercuric chloride resulted in increased mortality in both male and female mice (ICR strain) at 3.1 mg Hg/kg/day (Mitsumori et al. 1981). Chronic (104 weeks) dietary exposure to methylmercuric... 

The only information located regarding respiratory effects in animals after oral exposure to organic mercury comes from a study in which rats were exposed to methylmercuric chloride in the diet for 2 years (Verschuuren et al. 1976). This study showed no treatment-related histopathological lesions in... 

A decrease in heart rate was observed in male rats given 2 gavage doses of 12 mg Hg/kg as methyl-mercuric chloride (Arito and Takahashi 1991). An increase in systolic blood pressure was observed in male rats after daily oral gavage doses of 0.4 mg Hg/kg/day as methylmercuric chloride for 3-4 weeks (Wakita 1987). This effect began approximately 60 days after initiation of exposure and persisted for at least 9 months. No treatment-related histopathological changes were observed in the hearts of rats exposed to 0.1 mg Hg/kg/day as methylmercuric chloride in the diet for up to 2 years (Verschuuren et al. 1976). 

Exposure of rats to phenylmercuric acetate for 2 years resulted in necrosis and ulceration of the cecum at doses as low as 4.2 mg Hg/kg/day in drinking water no effect was observed at 1.7 mg Hg/kg/day in the feed (Fitzhugh et al. 1950 Solecki et al. 1991). Mice showed ulceration of the glandular stomach after 2 years of dietary exposure to methylmercuric chloride at 0.69 mg Hg/kg/day (Mitsumori et al. 1990). In contrast, no treatment-related histopathological lesions in the stomach or jejunum were observed in rats exposed via the diet to 0.1 mg Hg/kg/day as methylmercuric chloride (Verschuuren et al. 1976). 

No treatment-related changes were observed in hepatic parameters measured in rats exposed via the diet to 0.1 mg Hg/kg/day as methylmercuric chloride (Verschuuren et al. 1976). 

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