Methyl salicylate and menthol

Menthol, Methyl Salicylate, and Menthol Cream and Ointment... 

This cream and ointment contain menthol in an alcohol base gel, combinations of methyl salicylate, and menthol in cream and ointment bases, as well as a combination of methyl salicylate, menthol, and camphor in a nongreasy cream base all are suitable for topical application. The varieties include the ointment (methyl salicylate, 18.3% ... 

Sweat and Cheese descriptors overlap similar to the IR-generated odor maps. Minty smelling Methyl salicylate and Menthol produced distinct odor maps. 

Heng, M.C., Local necrosis and interstitial nephritis due to topical methyl salicylate and menthol. Cutis, 1987, 39, 442-444. 

Various over-the-counter preparations containing methyl salicylate and menthol have been used to treat musculoskeletal pain for many years, but few have been the subjects of clinical trials. Menthol is class ed as a counterirritant, producing a cooling sensation via activation of sped c thermoreceptors (Patel et al., 2007), while methyl salicylate has analgesic, anti-in ammatory, and vasodila-tory effects (Green and Flammer, 1989). 

Higashi, Y., Kiuchi, T, Furuta, K. 2010. Ef cacy and safety pro le of a topical methyl salicylate and menthol patch in adult patients with mild to moderate muscle strain A randomized, double-blind, parallel group, placebo-controlled, multicenter study, 32(l) 34-43. 

Topical analgesics sometimes are used for mild pain or as an adjunct to systemic therapy. There are limited data to support the use of salicylate-containing rubefacients (e.g., methyl salicylate and trolamine salicylate) or other counterirritants (e.g., menthol, camphor, and methyl nicotinate) in OA.32 See Chap. 57 for more information on these products when used for musculoskeletal disorders. 

S. K. Pant, P. N. Gupta, K. M. Thomas, B. K. Maitin, and C. L. Jain, Simultaneous determination of camphor, menthol, methyl salicylate, and thymol in analgesic ointments by gas-liquid chromatography, LC-GC, 8 322. 

Ointments Capreomycin sulfate GC Disperse in CHC13, 50°C, filtered, ISTD added 1,95% OV-210-1.5% OV-17, Supelco 130°C FID Resolved from menthol, methyl salicylate and thymol 10-campho-rsulphonic acid, HPLC [384] [378]... 

Richardson was not the first person to realize menthol s potential in pharmaceutical products. That honor goes to Jules Bengue, the French pharmacist who had created Ben-Gay as a treatment for sore muscles. Bengue had noted that menthol produced heat when you rubbed it on your skin. He combined it with the painkiller methyl salicylate and sold the concoction as a treatment for arthritis, gout, and neuralgia. Some Ben-Gay users with colds reported that sniffing the product cleared their sinuses. 

Active agents vary according to use. For controlling bad breath, 2iac salts, sodium lauryl sulfate, and flavors are used. To destroy oral microorganisms, chlorhexidine, cetylpyridinium chloride [123-03-5] and ben2alkonium chloride [68391-01-5] are valuable. Essential oils, such as thymol [89-83-8] eucalyptol [470-82-6] menthol, and methyl salicylate [119-36-8] reduce plaque-related gingivitis (see Oils, essential). Sodium fluoride aids ia caries coatrol. 

PerioGard, Peridex, Listerine, and Plax are trade name examples other similar generic rinsing agents are commercially available. Essential oils contain eucalyptol, methyl salicylate, thymol, and menthol. 

A mixture of essential oils consisting of thymol 0.06%, eucalyptol 0.09%, methyl salicylate 0.06%, and menthol 0.04% in an alcohol-based vehicle (26.9%) provides the plaque-inhibiting properties of rinsing agents such as Listerine. 

Flavouring agents— Flavouring agents e.g. peppermint, spearmint, menthol, cinnamon, oil of wintergreen (methyl salicylate) are used in conjunction with alcohol and humectants to overcome disagreeable taste. 

When 1 ml of gas was injected seven times from a single vial of mixed standard and internal standard solution, the coefficients of variation of the peak heights were 3.18%, 2.96%, and 0.85% for 1-menthol, camophon, and methyl salicylate, respectively. 

K. Nakajima and T. Yasuda, Simultaneous determination of 1-menthol, dl-camphor and methyl salicylate in pharmaceutical preparations for external application using headspace gas chromatography, Chiba-Ken Eisei Kenkyusho Kenkyu Haboku, 5 14-18 (1984). 

The British Vick contains a mixture of menthol, camphor and methyl salicylate but the American Vick also contains a further compound, L-methamphetamine. 

Alan Baxter lost his bronze medal in the winter Olympics in 2000 because he used an American Vick inhaler and not a British one.1,2 Note the position of the CH3 attached to the central carbon atom (Figure 2.18). The British Vick inhaler contains a mixture of menthol, camphor and methyl salicylate the American Vick inhaler also contains L-methamphetamine. This is used as a decongestant and has no performance-improving properties, whereas its optically active isomer D-methamphetamine (commonly known as speed ) is a prohibited drug and is a performance improver. However, the Olympic Committee does not distinguish between these two isomers in its detective work and chemical analysis. It therefore reported that his urine contained methamphetamine and did not report that it was the ineffective l form. The committee took the medal away from him. If they only had known their chemistry and all about optically active isomers. 

---