2-Methoxyacetic acid

METHOXYETHANOL (EGME) and 2-METHOXY ETHYL ACETATE (EGMEA) 2-Methoxyacetic acid in urine End of shift at end of workweek Nq... 

CN (15 C/i)-methoxyacetic acid 2-[2-[[3-(l H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-l,2,3,4-... 

Smialowicz, R.J. et al., Differences between rats and mice in the immunosuppressive activity of 2-methoxyethanol and 2-methoxyacetic acid, Toxicology, 74, 57, 1992. 

Representative Procedure for Bronsted Acid Promoted Glycosylation with Cl-Hemiacetal Donors Using Methoxyacetic Acid [11]... 

A mixture of hemiacetal donor (1 mmol), glycosyl acceptor (1.2 equiv), methoxyacetic acid (0.1 equiv) and Yb(OTf)3 (0.1 equiv) in dichloromethane (40 ml) was... 

Methoxyacetic acid A-Acetylglycine Glycolic acid Formic acid Acetic acid Malonic acid Succinic acid o-Phosphoric acid Citric acid ACN... 

Methoxyacetic acid Formic acid Acetic acid THF... 

PROPYLENE OXIDE ETHYL FORMATE METHYL ACETATE PROPIONIC ACID 3-MERCAPTOPROPIONIC ACID LACTIC ACID METHOXYACETIC ACID TRIOXANE THIACYCLOBUTANE 1-BROMOPROPANE... 

Beckett and Hua (2000) investigated the sonolytic decomposition of 1,4-dioxane in aqueous solution at 25 °C at discrete ultrasonic frequencies. They found that the highest first-order decomposition rate occurred at 358 kHz followed by 618, 1,071, and 205 kHz. At 358 kHz, 96% of the initial 1,4-dioxane concentration was decomposed after 2 h and the pH of the solution decreased to 3.75 from 7.50. Major decomposition intermediates were ethylene glycol diformate, methoxyacetic acid, formaldehyde, glycolic acid, and formic acid. 

Methidathion oxon, see Methldathion Methiocarb sulfone, see Methlocarb Methiocarb sulfoxide, see Methiocarb Methionine, see Thiram Methoxyacetaldehyde, see Alachlor Methoxyacetic acid, see 1,4-Dioxane p-Methoxybenzaldehyde, see Methoxychlor p-Methoxybenzoic acid, see Methoxychlor... 

Coimnercially acceptable rates were obtained by using a methoxyacetic acid ester as the acyl donor, which is attributed to hydrogen bond formation with the ether oxygen in the active site of the enzyme [20]. As shown in Scheme 6.6, the process affords an amide of the reacting enantiomer together with the other enan-homer as the free amine. 

It has been hypothesized that DMEP acts by in vivo hydrolysis to 2-methoxyethanol, also a known teratogen, which in turn is metabolized to methoxyacetic acid, the proximate teratogen. ... 

Ritter EJ, Scott WJ Jr, Randall JL, et al Teratogenicity of dimethoxyethyl phthalate and its metabolites methoxyethanol and methoxyacetic acid in the rat. Teratology 32 25-31, 1985... 

Scott WJ, Fradkin R, Wittfoht W, et al Teratologic potential of 2-methoxyethanol and transplacental distribution of its metabolite, 2-methoxyacetic acid, in non-human primates. Teratology 39 363-373, 1989... 

Methoxyethyl acetate is hydrolyzed in vivo to form 2-methoxyethanol, which is subsequently metabolized to 2-methoxyacetic acid, a proported teratogenic substance. Consequently, the acetate is expected to show profiles of developmental and reproductive toxicity similar to those of 2-methoxyethanol (qv). In a case report, a woman who was extensively exposed to 2-methoxyethyl acetate, both dermally and probably by inhalation during pregnancy, gave birth to two sons with hypospadias. Because family history and medical examination showed no overt risks other than the significant exposure of the mother, and because 2-methoxyethyl acetate can cause teratogenic effects in animals, the malformations were attributed to the exposure. 

Clarke DO, Duignan JM, Welsch F (1992) 2-Methoxyacetic acid dosimetry-teratogenicity relationships in CD-1 mice exposed to 2-methoxyethanol. Toxicol Appl Pharmacol, 114 77. 

Methoxyacetic acid [625-45-6] M 90.1, b 97 /13-14mm, n 1.417, d 1.175. Fractionally crystd by repeated partial freezing, then fractionally distd under vacuum through a vacuum-jacketed Vigreux column 20cm long. 

A number of compounds cause specific damage to the male reproductive system. Thus, cadmium, 2-methoxyacetic acid, dibromochloropiopane, and diethylhexylphthalate all cause different... 

In order to obtain better insight into buffer effects on swelling rates, extensive studies were performed with buffers containing acetic acid (HAc), methoxyacetic acid (MeOHAc), and chloroacetic acid (ClHAc), at various buffer concentrations and pH values and at I = 0.1 M, in MMA/DMA 70/30 gels [44]. These studies had the advantage that only two possible charge states on the buffer (0 and — 1) are possible. However, the relatively low pK values of the buffers (4.62, 3.42, and 2.74 for HAc, MeOHAc, and ClHAc, respectively) meant that studies had to be performed in regions of low pH. 

The optically active alcohols can be liberated from the coordination complexes by achiral reagents. One possibility would be the addition of methoxyethyl alcohol 7 which form more stable complex with DBTACa then the resolved chiral alcohols. Practically quantitative recovery of 8, 9 or 10 was achieved by the use of methoxyacetic acid (12) that form crystalline mixed salt with DBTACa. The free optically active alcohols were isolated from the filtrate in 90-95 % yields. 

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