Methoxyacetate

METHOXYETHANOL (EGME) and 2-METHOXY ETHYL ACETATE (EGMEA) 2-Methoxyacetic acid in urine End of shift at end of workweek Nq... 

Chloroacetate, 160 Dichloroacetate, 163 Trichloroacetate, 163 Trifluoroacetate, 164 Methoxyacetate, 165 Triphenylmethoxyacetate, 165 Phenoxyacetate, 165 p-Chlorophenoxyacetate. 166 Phenylacetate, 166 p-P-Phenylacetate, 166 Diphenylacetate. 167 Nicotinate, 167... 

NH3/MeOH or NH3/H2O, 78% yield. In nucleoside derivatives, the methoxyacetate is cleaved 20 times faster than an acetate. It can he cleaved in the presence of a benzoate. 

Various diastereoselective Michael reactions are based on y-bromo-, y-alkyl-, or y-alkoxy-2(5//)-furanones following the trans-face selectivity shown in Section 1.5.2.3.1.2. Thus the lithium enolates of esters such as ethyl propanoate, ethyl a-methoxyacetate and ethyl a-phenylacetate add to methoxy-2(5/f)-furanone with complete face selectivity269-273 (see Section 1.5.2.4.4.2.). 

CN (15 C/i)-methoxyacetic acid 2-[2-[[3-(l H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-l,2,3,4-... 

Alkoxyalkanoate esters have been used as prodrugs to improve the oral bioavailability of antiviral agents such as (+)-cyclaradine (carbocyclic arabino-furanosyl adenine) [41]. (+)-Cyclaradine has been shown to be effective against herpes simplex virus in tissue culture at noncytotoxic concentrations. Two prodrugs of (+)-cyclaradine, namely, (+)-cyclaradine-5 -methoxyacetate (CM) and (+)-cyclaradine-5,-ethoxypropionate (CE) (Fig. 2), may be promising candidates... 

A sample of redistilled material in a screw capped bottle exploded 15 weeks after capping. This was attributed to development of internal pressure (probably of hydrogen chloride arising from hydrolysis, and perhaps also of chloromethane from scission). (The editor has also known methoxyacetic mixed anhydrides to decarbonylate, releasing carbon monoxide)... 

After treatment of XXXVI with aqueous barium hydroxide, the liquor contained formic, methoxyacetic, and ethoxyacetic acids, methoxyacetone, and ethoxyacetone, produced by the two modes of cleavage XXXVIa and XXXVIb. Formic acid was converted with red mercuric oxide to carbon dioxide this was recovered as barium carbonate, the radioactivity of which was a measure of the C14 incorporated into Cl of kojic acid in the biosynthetic process. The alkoxyacetones were removed from the liquor by steam distillation, and converted to iodoform and a mixture of methoxy- and ethoxy-acetic acids. The iodoform was recovered by filtration its radioactivity indicated the proportion of C14 incorporated into C4. The alkoxy-... 

Smialowicz, R.J. et al., Differences between rats and mice in the immunosuppressive activity of 2-methoxyethanol and 2-methoxyacetic acid, Toxicology, 74, 57, 1992. 

A new approach to ( )-deserpidine has been published by Wenkert (264) in preliminary form. The characteristic feature of the synthesis is the addition of a nucleophile to a pyridinium salt, followed by acid-induced ring closure. For the preparation of the desired pyridinium salt 532, nicotinaldehyde was condensed with methyl methoxyacetate, and the methyl acrylate derivative 531 was alky-... 

Representative Procedure for Bronsted Add Promoted Glycosylation with Cl-Hemiacetal Donors Using Methoxyacetic Add 128 Representative Procedure for Lewis Acid Promoted Glycosylation with Cl-Hemiacetal Donors Using Sn(OTf)2 and LiC104 129... 

A mixture of hemiacetal donor (1 mmol), glycosyl acceptor (1.2 equiv), methoxyacetic acid (0.1 equiv) and Yb(OTf)3 (0.1 equiv) in dichloromethane (40 ml) was... 

Methoxyacetic acid A-Acetylglycine Glycolic acid Formic acid Acetic acid Malonic acid Succinic acid o-Phosphoric acid Citric acid ACN... 

Methoxyacetic acid Formic acid Acetic acid THF... 

PROPYLENE OXIDE ETHYL FORMATE METHYL ACETATE PROPIONIC ACID 3-MERCAPTOPROPIONIC ACID LACTIC ACID METHOXYACETIC ACID TRIOXANE THIACYCLOBUTANE 1-BROMOPROPANE... 

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