Mesenchymal chondrosarcoma

S-100 protein is seen only in the chondroid islands of mesenchymal chondrosarcoma. 

Polyphenotypic small round cell tumor (DSMCT) Mesenchymal chondrosarcoma... 

Mesenchymal chondrosarcoma (MCS) is an aggressive cartilaginous neoplasm that is seen most often in young adults, commonly in extraskeletal locations. It is typified by a small-cell population that is similar to that seen in classic ES, except that MCS is punctuated by islands of primitive cartilage that appear to arise from the small cells in a manner simulating embryonic chondrogene-sis. Another salient feature of MCS is the presence of hemangiopericytoid vasculature. 

S-100 protein, vimentin, CD57, and lysozyme.Some examples also show strong ONN staining, unlike the profiles of conventional chondrosarcoma and mesenchymal chondrosarcoma. 744... 

Swanson PE, Lillemoe TJ, Manivel JC, et al. Mesenchymal chondrosarcoma An immunohistochemical study. Arch Pathol Lab Med. 1990 114 943-948. 

Kurotaki H, Tateoka H, Takeuchi M, et al. Primary mesenchymal chondrosarcoma of the lung A case report with immunohistochemical and ultrastructural features. Acta Pathol Jpn. 1992 42 364-371. 

Rushing EJ, Armonda RA, Ansari Q, et al. Mesenchymal chondrosarcoma A clinicopathologic and flow cytometric study of 13 cases presenting in the central nervous system. Cancer. 1996 77 1884-1891. 

Brown RE, Boyle JL. Mesenchymal chondrosarcoma Molecular characterization by a proteomic approach, with morphogenic and therapeutic implications. Ann Clin Lab Sci. 2003 33 131-141. 

Granter SR, Renshaw AA, Fletcher CD, et al. CD99 reactivity in mesenchymal chondrosarcoma. Hum Pathol. 1996 27 1273-1276. 

The mesenchymal chondrosarcoma is rare. It originates in the intracranial and spinal meninges and cauda equina in childhood and young adulthood. " The... 

Rushing EJ, Mena H, Smirniotopoulos JG. Mesenchymal chondrosarcoma of the cauda equina. Clin Neuropathol. 1995 14 150-153. 

T-cell lymphoma, ALCL, AML, GIST, breast metaplastic carcinoma, ovarian sex cord stromal tumors, synovial sarcoma, Merkel cell carcinoma, endocrine and neuroendocrine tumors, desmoplastic small round cell tumor, melanoma, nephroblastoma, ependymoma, mesenchymal chondrosarcoma, extrarenal malignant rhabdoid tumor, rhabdomyosarcoma, meningeal... 

Since extraskeletal myxoid chondrosarcoma has no specific immunohistochemi-cal profile and its morphology resembles other mesenchymal tumors, the above-mentioned translocations are pathognomonic for this tumor and can be used as further specific molecular markers for the diagnosis of extraskeletal myxoid chondrosarcoma. 

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