Megakaryocytes, expression

Haidaris, P. J., Francis, G. W., Sporn, L. A., Arvan, D. S., Collichio, F. A., and Marder, V. J. (1989). Megakaryocyte and hepatocyte origins of human fibrinogen biosynthesis exhibit hepatocyte-specific expression of gamma chain-variant polypeptides. Blood 74, 743-750. 

I Zucker-Franklin D, Cao YZ. Megakaryocytes of human immunodeficiency virus-infected individuals express viral RNA. Proc Natl Acad Sci USA 1989 86 5595-5599. 

In addition to platelets, CD36 is expressed on various other cells such as megakaryocytes , monocyte , fetal eiythroc es, reticuloi es, microvascular endothelial cells , and several tumour cells . ... 

The O2P, integrin is expressed in a variety of cell types. In cells of haematopoietic lineage, expression is restricted to megakaryocytes and platelets. On endothelial cells and fibroblasts and many epithelial cell types, OjP, additionally binds to laminin" The echovirus 1, a non-enveloped RNA-virus implicated in febrile illness and viral meningitis, binds to Ojp," . OjP, bears the clinically important Br(a) and Br(b) alloantigenic determinants, which can result in antibody-mediated platelet destruction. A single base change results in a substitution of Lys in Br(a) to Glu in Br(b) at amino acid residue 505". ... 

In conclusion, PAF is a unique and potent endogenous lipid mediator which activates platelets. Increases or decreases in PAF levels in vivo can profoundly influence vascular hemostasis. PAF activates multiple signaling pathways in platelets but the molecular properties of platelet PAF receptor and its regulation are poorly understood. Similarly the expression of PAF receptor in megakaryocyte development in normal and disease states would also be a topic of interest in the feture. 

Block KL, Pcmcz M Platelet glycoprotein Hh gene exi ession as a modd of megakaryocyte-specific expression. StemCdls 13 135-145,1995. 

Block KL, Shou Y, Poncz m An Ek/Spl interaction in the S -flanking region of the megakaryocyte-specific alpha lib gene appears to stabilize Spl binding and is essential for expression of this TATA-less gene. Blood 88 2071-2080,1996. 

WallerattiT, GsthL Aulitzky WE, Pollodc JS, Kleinert H, Forstermann U (1997) Identification of NO synthase isofonns expressed in human neutrophil granulocytes, megakaryocytes and platdets. Thromb Haemostas 77 163-167. 

IL-6 synergizes with IL-3 (and probably GM-CSF) to support proliferation of neutrophil, monocyte, eosinophil, and megakaryocyte colonies. Increased mesangial proliferation in the kidney inhibits the growth of fibroblasts and induces class IHLA expression on their cell surfaces. 

In various pathophysiological conditions iNOS not only is expressed in macrophages, but can also be induced in various other cells, including fibroblasts, Kupffer s cells, hepatocytes, neutrophils, mesangial cells, chondrocytes, pancreatic islet cells, microglia, epithelial and endothelial cells, smooth muscle cells, cardiac myocytes, megakaryocytes, and various tumor cells (e.g., adenocarcinoma cells) (see Moncada et al., 1991 Nathan, 1992 ... 

A. Overview The innate immune system initiates the defense against pathogens and antigenic insult. It involves the concerted actions of complement components, lysozyme, macrophages, and neutrophils. If the innate response is inadequate, the adaptive immune response is mobilized. This culminates in the activation of T lymphocytes, the effectors of cell-mediated immunity and the production of antibodies, by activated B lymphocytes, the effectors of humoral immunity. The cell types involved in immune responses can be identified by specific cell surface components or clusters of differentiation (CDs). For example, T helper cells bear the CD4 protein complex, whereas cytotoxic T lymphocytes express the CDS protein complex. Clusters of differentiation also can be used to characterize other types of hematopoietic cells, including precursors of granulocytes, megakaryocytes, and erythrocytes (Chapter 33). 

---