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Peripheral blood smear

History (previous crises, previous medications, recreational drug use), physical examination (mandatory fundoscopic examination, blood pressure on all limbs), urinalysis, and electrolytes, blood urea nitrogen, creatinine, peripheral blood smear, complete blood count, electrocardiogram (ECG), chest X-ray, and head CT... [Pg.45]

The peripheral blood smear demonstrates sickle forms (see Fig. 65-2). [Pg.1009]

Fig. 5. Spiculed red blood cells (echinocyte) in peripheral blood smear of a splenectomized patient with pyruvate kinase deficiency. Fig. 5. Spiculed red blood cells (echinocyte) in peripheral blood smear of a splenectomized patient with pyruvate kinase deficiency.
Fig. 6. Basophilic stippling in peripheral blood smear of a patient with pyrimidine 5 -nucleotidase deficiency. Fig. 6. Basophilic stippling in peripheral blood smear of a patient with pyrimidine 5 -nucleotidase deficiency.
Macrocytic anemias are characterized by increased mean corpuscular volume (110 to 140 fL). One of the earliest and most specific indications of macrocytic anemia is hypersegmented polymorphonuclear leukocytes on the peripheral blood smear. Vitamin B12 and folate concentrations can be measured to differentiate between the two deficiency anemias. A vitamin B12 value of less than 150 pg/mL, together with appropriate peripheral smear and clinical symptoms, is diagnostic of vitamin B12-deficiency anemia. A decreased RBC folate concentration (less than 150 ng/mL) appears to be a better indicator of folate-deficiency anemia than a decreased serum folate concentration (less than 3 ng/mL). [Pg.379]

Bacterial infections are associated with elevated granulocyte counts (neutrophils, basophils), often with increased numbers of immature forms (band neutrophils) seen in peripheral blood smears (left-shift). With infection, peripheral leukocyte counts may be very high, but are rarely higher than 30,000 to 40,000/mm3. Low neutrophil counts (neutropenia) after the onset of infection indicate an abnormal response and are generally associated with a poor prognosis for bacterial infection. [Pg.390]

Gram-positive bacilli on unspun peripheral blood smear or CSF... [Pg.399]

A 16-year old girl was treated empirically with chloroquine (total 450 mg of chloroquine base) for fever, had no malarial parasites in the peripheral blood smear, but had severe hypoglycemia of 1.5 mmol/1 (27 mg/dl) (49). [Pg.591]

Her hemoglobin level was 10.9 g/dL (moderately anemic), white blood cell count was 5200/p.L (normal), and her platelet count was 103,000/pL (the lower limit of normal for platelet count is 140,000/pL). Examination of a peripheral blood smear revealed clear evidence of malaria due to Plasmodium vivax (Figure A.4). [Pg.443]

By 6 months of age, psychomotor retardation is usually obvious. Joint immobility progresses with development of claw-hand deformities and kyphoscoliosis. Hepatomegaly is prominent, but splenomegaly is minimal. Corneal haziness may be present but is subtle, and corneal opacities due to the accumulation of storage material are not as striking as in Hurler syndrome. Examination of peripheral blood smears reveals the presence of abnormal inclusions in cells such as lymphocytes, and increased lysosomal enzyme activity in whole blood as well as cultured fibroblasts is confirmatory of I-cell disease. [Pg.182]

Collagen Elastic fibers Peripheral blood smears Differentiation of blood cells... [Pg.905]

One study revealed damaged erythrocytes in the peripheral blood of mice (Luke et al. 1988b). Cytotoxic damage in the bone marrow was dependent on strain and exposure duration. Peripheral blood smears were analyzed weekly from three strains of mice (DBA/2, B6C3Fj, and C57BL/6) exposed to 300 ppm benzene for 13 weeks (6 hours per day) for either 5 days per week (Regimen 1) or 3 days per week (Regimen 2). [Pg.64]

Choy WN, MacGregor JT, Shelby MD, et al. 1985. Induction of micronuclei by benzene in B6C3F, mice Retrospective analysis of peripheral blood smears from the NTP carcinogenesis bioassay. Mutat Res 143 55-59. [Pg.365]

A 14-year-old girl developed tachycardia, hypotension, and disseminated intravascular coagulation after her first dose of oral ciprofloxacin 500 mg for presumed pyelonephritis. A peripheral blood smear showed spirochetes consistent with Borrelia species. [Pg.785]

MM is a 48-year-old man with a history of chronic HCV infection. He complains of increasing fatigue and shortness of breath over the past 2 weeks. He started therapy for his chronic HCV infection 4 weeks ago with inter-feron-Kjb and ribavirin. His serum ALT is 80 U/L, serum Cr 1.2 mg/dL, INR 1.1, hematocrit 22%, hemoglobin 7 g/dL, total bilirubin 12 mg/dL, and G6PD within normal limits. Peripheral blood smear reveals hemolysis. Which of the following drugs is the most likely to cause hemolytic anemia ... [Pg.140]

Case Conclusion CC s oncologist decides to stop the interferon therapy and initiate a trial of imatinib mesylate. She tolerated the imatinib well, with minimal complaints of lower extremity edema for which she was prescribed furosemide. Six weeks after starting imatinib, CC s peripheral blood smear appeared normal (hematologic response) and cytogenetic evaluation of her bone marrow revealed disappearance of the Philadelphia chromosome. [Pg.158]

Figure 31 -9 Peripheral blood smear from patients with homozygous Hb E (a) and homozygous Hb S (b). Figure 31 -9 Peripheral blood smear from patients with homozygous Hb E (a) and homozygous Hb S (b).
Figure 31-13 Peripheral blood smear of an individual with P -thalassemia. (Courtesy Dr. G. Clarke, Dynacare Kasper Medical Laboratories.)... Figure 31-13 Peripheral blood smear of an individual with P -thalassemia. (Courtesy Dr. G. Clarke, Dynacare Kasper Medical Laboratories.)...
Typical CBC results include severe anemia with the Hb concentration between 30 and 65g/L, MCV 48 to 72 L, and the mean corpuscular hemoglobin concentration (MCHC) 230 to 320 g/L. On the peripheral blood smear, a characteristic markedly abnormal RBC morphology is noted, which includes a large number of microcytes, numerous target... [Pg.1179]

HPLC analysis shows a large Hb F peak with a reduced Hb A peak. Hb Aa is above the reference interval at concentrations greater than those associated with P-thalassemia minor. Bands in the A and F positions are seen on electrophoresis at both alkaline and acid pH. The Hb is significantly reduced (60 to 100 g/L). The peripheral blood smear shows the same features as p -thalassemia, including aniso-cytosis, hypochromia, target cells, basophilic stippling, and nucleated RBCs. [Pg.1181]

The peripheral blood smear shows microcytic RBCs with occasional hypochromia, poikilocytosis, and target cells. [Pg.1181]

CBC analysis of an individual homozygous for Hb S indicates a moderate to a major decreased Hb level (60 to 100 g/L) with a normal to increased MCV and MCH. In individuals with a concurrent thalassemia, the Hb is farther decreased and both the MCV and MCH are lowered. In the neonate the peripheral blood smear shows the occasional sickle and target cells and Howell-Jolly bodies. As a patient s age increases, these features of hyposplenism become increasingly evident. In the adult the percentage of sickle cells observed can be as much as 30% to 40%. In the setting of a sickle cell crisis, fewer sickle cells may be present than when the individuals are clinically well. Howell-Jolly bodies, target cells, Pappenheimer bodies, boat-shaped cells, and nucleated RBCs are noted. The platelet count and neutrophil counts are elevated. Sometimes blister cells in which the Hb appears to be present in only one half of the cell is observed. [Pg.1183]


See other pages where Peripheral blood smear is mentioned: [Pg.1000]    [Pg.1416]    [Pg.1416]    [Pg.1419]    [Pg.1421]    [Pg.151]    [Pg.205]    [Pg.58]    [Pg.236]    [Pg.242]    [Pg.243]    [Pg.244]    [Pg.91]    [Pg.1229]    [Pg.1381]    [Pg.12]    [Pg.188]    [Pg.360]    [Pg.443]    [Pg.523]    [Pg.51]    [Pg.326]    [Pg.328]    [Pg.19]    [Pg.1171]    [Pg.1183]   
See also in sourсe #XX -- [ Pg.1812 ]




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