Mass spectrometry websites

Mass Spectrometry Wiki Mind Map A blog on mass spectrometry, websites, discussion groups, mailing lists, and other links and items of interest to the mass spectrometry community. 

American Society for Mass Spectrometry website, www.asms.org... 

There are a number of specific texts devoted to the various aspects of mass spectrometry [2-7]. In this chapter, a brief overview of the technique will be provided, with particular attention being paid to those aspects necessary for the application of LC-MS. In addition, a number of manufacturers provide educational material on their websites (for further details, see the Bibliography section at the end of this text). 

The purpose of the present review, then, as requested by the Editor, is to review some of the types of method we have developed and exploited in Aberystwyth for the rapid, precise, quantitative, and - where possible - non-in-vasive measurement of bioprocesses. Our website http //gepasi.dbs.aber.ac.uk may also be consulted. We start with mass spectrometry. 

The document Note for Guidance " available on website www.efsa.eu.int provides guidance on provision of migration (and other) data for the authorisation of new substances for food contact application. In particular, method performance should be adequate at the given SML with data obtained on the precision and the limits of detection and quantitation. In the event that the SML is exceeded then confirmation of the level present is essential, preferably using mass spectrometry. 

CSMS). The Canadian Society for Mass Spectrometry is a society dedicated to the promotion of mass spectrometry. There are over 120 CSMS members involved in mass spectrometric research and development in university, industrial and governmental laboratories. The CSMS publishes a newsletter every six months and hosts the Tandem Mass Spectrometry Workshop in Lake Louise, Alberta. It can be reached at L/C 2201C Banting Building, Tunny s Pasture, Ottawa, Ontario, Canada, K1A 0L2. Website http //www.csms.inter.ab.ca... 

JEOL USA, Inc., www.jeol.com. Has tutorials on basic mass spectrometry and on mass analyzers, and links to other MS websites. 

Figure 10.30 The difference between low-resolution and high-resolution MS. The nominal mass of the molecule C101H145N34O44 = 2537 Da. Atthe low resolution of 200, a single peak is measured with an average mass atthe peak maximum = 2539.5 Da. A high-resolution instrument (resolution = 2500) separates the monoisotopic peaks and permits measurement of exact masses. [Courtesy of Professor Gary Siuzdak, Scripps Research Institute Center for Mass Spectrometry (www.masspec.scripps.edu). The website has a number of tutorials on MS.]...

American Society for Mass Spectrometry (ASMS), http //www.asms/org. The website of the ASMS is an excellent source of information about general and specialized meetings, publications, and a variety of functions provided by the society. Membership fees are reasonable and, indeed, it is a good idea for mass spectrometrists in the United States (and often in other countries) to maintain membership. 

In addition to the ASMS, there is the European Society for Mass Spectrometry and at least 20 individual societies in various countries, e.g.. United Kingdom, France, Germany, Canada, and India, each with its own website. 

Ashcroft AE (1997) Ionization Methods in Organic Mass Spectrometry. Cambridge Royal Society of Chemistry. British Mass Spectrometry Society website, www.bmss. org.uk... 

ASTM (2002) D1971-02 Standard Practices for Digestion of Water Samples for Determination of Metals by Flame Atomic Absorption, Graphite Furnace Atomic Absorption, Plasma Emission Spectroscopy, or Plasma Mass Spectrometry. ASTM International. For referenced ASTM standards, visit the ASTM website www.astm.org. 

An excellent source of information about the SI can be found at the website of the US National Institute for Standards and Technology (NIST) http //physics. nisLgov/cuu/Units/index.html Here we shall be mainly concerned with those quantities that directly affect quantitative measurements of amounts of chemical substances by mass spectrometry. However, it is appropriate to briefly describe some general features of the SI. 

Because analytes plus residual mobile phase (and often also collision gas in the case of tandem mass spectrometry) are being injected continuously into a mass spectrometer, the vacuum pumps must be capable of continuously evacuating significant input gas flows in order to maintain a sufficiently low pressure within the analyzer and detector. Before describing the types of pump commonly employed, it is necessary to discuss the concepts of gas flow and its measurement. In this regard two helpful websites are recommended for both introductory and more detailed discussions www.newequation.net and www.vacuumlab.com. 

The general application of ion chromatography (IC) to environmental samples has been described in a review [1]. More laboratories are looking at speciation as methods are being developed. As well as the traditional ion chromatography companies, most of the inductively coupled plasma mass spectrometry (ICP-MS) companies (PE, Agilent, Thermo, Varian) have done applications or offer speciation columns and/or kits. A website on speciation called Evisa is sponsored by the EU and provides much information (www.spedation.net). There is a links tab that lists various elemental metals, with further Usts of references and certified methods on several different spedes of each particular element... 

Chapter 8 develops the characterization of organic materials at the microscale level by spectroscopic techniques. The chapter starts with a brief discussion of the interpretation of infrared (IR) group fi equendes and is followed by a more detailed treatment of nuclear magnetic resonance (NMR) spectral data, a brief discussion of ultraviolet-visible (UV-vis) spectroscopy, and a brief introduction to the theory, experimental techniques, and applications of mass spectrometry to organic chemistry. A more detailed introduction to the theoretical basis for these spectroscopic techniques is also presented on the accompanying website. 

Elements and compounds can be detected by a variety of instrumental methods (see Chapter 21, and Chapter 22 on the accompanying website), for example mass spectrometry (MS), nuclear magnetic resonance (NMR), various forms of chromatography, inductive coupled plasma spectroscopy (ICP) and infrared spectroscopy (IR). These instruments allow chemists to probe and discover which elements are present in the substance, their quantities and, in some cases, give information about the structure of the substance. Forensic scientists also make use of these techniques because they are very accurate and sensitive they only require tiny amounts of sample. 

Analytical techniques used in qualitative analysis include flame tests (Chapter 2) and precipitation reactions (Chapters 3 and 13). Analytical techniques used in quantitative analysis include titrations (Chapter 1), inductively coupled plasma (ICP) spectroscopy (Chapter 22 on the accompanying website), ultraviolet—visible spectroscopy (Chapter 23 on the accompanying website), infrared spectroscopy and various chromatographic techniques (Chapter 23). Analytical techniques used in structural analysis include NMR, IR spectroscopy, mass spectrometry and visible—ultraviolet spectroscopy. Important areas that employ analytical techniques include ... 

Method 525.1, Determination of organic compoimds in drinking water by liquid-solid extraction and capillary column gas chromatography/mass spectrometry (Revision 2.2). Environmental Monitoring Systems Laboratory, Office of Research and Development, US Environmental Protection Agency, Cincinnati, OH. Website http //nepis.epa.gov/pubtitleORD.htm... 

This excellent website presented by Professor WUham Reusch from the Department of Chemistry at the Michigan State University includes background material for infrared spectroscopy, NMR spectroscopy, UV spectroscopy and mass spectrometry. Some problems are included. The site includes links to other available sites for spectral problems. 

All the mass spectra illustrated on these pages were obtained by electron ionization at an ionization potential of 70 eV on quadrupole mass spectrometers. The website also offers the Bibliography of Mass Spectra with lists of references mainly concerning the use of mass spectrometry for structural analysis of fatty acids. 

Tables of possible combinations of carbon, hydrogen, oxygen, and nitrogen and intensity ratios for the M + 1 and M + 2 peaks for each combination have been developed. An example of this sort of table is found in Appendix 11. More extensive tables of intensity ratios for the Af + 1 and M + 2 peaks may be found in specialized books on interpreting mass spectra. Accurate calculation of the relative intensities of isotope peaks in a molecular ion cluster for compounds containing several elements with isotopes is time consuming to do by hand as it requires polynomial expansions. Fortunately, many websites dealing with mass spectrometry have isotope calculators that make this a trivial task. Some of these sites may be found in the references at the end of this chapter.

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