Marion

When The Nylons Bloom Again, words by George Marion, Jr. music by Thomas Fats Waller... 

Tobacco and its alkaloids have long ceased to have any therapeutic importance, but their extensive use as insecticides and the demand for nicotine for the manufacture of nicotinic acid have stimulated interest in processes of extraction and methods of estimation. On the latter subject there is a voluminous literature, of which critical resumes have been published by various authors.Recent work on this subject has been specially concerned with (1) the development of miero- and semi-miero-methods suitable for estimating nieotine in tobacco smoke and the distribution of nieotine on sprayed garden produce, in treated soils and in tobaeeo leaves,(2) the study of conditions necessary to ensure satisfactory results in using particular processes, " and (3) methods of separation and estimation of nicotine, nomicotine and anabasine in mixtures of these bases. ) In the United States and in Russia considerable interest is being shown in the cultivation of types of tobacco rich in nicotine, in finding new industrial uses for tobacco and its alkaloids, and in possible by-products from tobacco plants such as citric and malic acids, i " Surveys of information on tobacco alkaloids have been published by Jackson, i Marion and Spath and Kuffner. ... 

B. HCl, m.p. 242-3°). The methiodide, m.p. 104-7°, of this, on treatment with potassium hydroxide in methyl aleohol, yielded 5 6-pimethoxy-8-vinylphenanthrene, m.p. 86-7°, along with dimethyl-de-iV-methylnorroemerine, oil, [aju + 13-55° (EtOH) the methiodide, m.p. 278°, of this, on like treatment also yielded 5 6-dimethoxy-8-vinyl-phenanthrene, whose identity was established by its oxidation by permanganate to 5 6-dimethoxyphenanthrene-8-earboxylie aeid. Rcemerine is, therefore, 5 6-methylenedioxy-iV-methylaporphine, and this eon-stitution has been confirmed by Marion and Grassie s synthesis of the alkaloid. 

Barger el al. took the view that the alkaloid contains two tryptamine residues, one represented in the degradation products by -methyltrypt-amine, and the other by methyl-3-carboline, and on this basis proposed formula (II). Manske and Marion, on the contrary, regard 2V-methyl-tryptamine and 3-carboline as originating from the same moiety of the molecule, the other half being represented by 4-methylquinoline, and on this conception based formula (III). 

Aconitum lycoctonum. From the roots of this species Hiibschmann isolated the amorphous alkaloids acolyctine and lycoctonine. Dragen-dorff and Spohn showed that Hiibschmann s alkaloids were probably decomposition products of lycaconitine, C2,H3403N2. 2H2O, which they isolated along with myoctonine, 27 30 8 2 - 5H2O. These results liave been considerably extended by Schulze and Bierling, and more recently by Marion and Manske, for lycoctonine. 

D. consolida, L. From this species Keller isolated three alkaloids of which one (Base A ) was well defined. Markwood obtained three crystalline alkaloids of which delcosine was probably Keller s base A, and Cionga and Iliescu have added to Markwood s observations, but failed to obtain his third base. This work has recently been critically revised by Marion and Edwards, ( > who have isolated from the seeds six alkaloids of which two, delcosine and delsoline, were already known another, consolidine, may be Markwood s third base, and the remaining three are new records for this species, viz. delsonine, lycoctonine and anthranoyllycoctonine. They have also altered the empirical formulas of the alkaloids delcosine and delsoline. 

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