Malignant melanoma soft-tissue sarcomas

TNF- has been extensively tested in the therapy of various malignancies, but results have been disappointing due to dose-limiting toxicities. One exception is the use of intra-arterial high-dose TNF- for malignant melanoma and soft tissue sarcoma of the extremities. In these settings, response rates greater than 80% have been noted. [Pg.1203]

The ability of melanoma to simulate the appearance of various soft tissue sarcomas is also well documented. These include malignant peripheral nerve sheath tumors, gastrointestinal stromal tumors, epithelioid angiosarcoma, rhabdoid tumors, osteosarcomas, and primitive neuroectodermal tumors, to name a few. The detailed immunophenotypic properties of those lesions are provided elsewhere in this book. However, none of them manifests reactivity for gplOO-related melanocytic markers or tyrosinase, making those markers essential to the differential diagnostic process. [Pg.199]

Lodding P, Kindblom LG, Angetvall L. Metastases of malignant melanoma simulating soft tissue sarcoma a clinicopathological, light- and electron microscopic and immunohistochemical study of 21 cases. Virchows Arch A. 1990 417 377-388. [Pg.204]

Malignant pancreatic insulinoma malignant carcinoid Malignant melanoma Hodgkin s disease soft-tissue sarcomas glioma melanoma... [Pg.854]

NSCLC Non-small cell lung cancer, Ad Adenocarcinoma, SCC Squamous cell carcinoma, SCLC Small cell lung cance, H N Head and neck, MM Malignant melanoma, MG Malignant glioma, STS Soft tissue sarcoma, PM Pleural mesothelioma, CLL Chronic lymphocytic leukaemia... [Pg.99]

FIGURE 4.24 Clear cell sarcoma labels for S-100 protein in accord with the contention that it is a malignant melanoma of soft tissues. [Pg.113]

Clear cell sarcoma (CCS) was formerly thought to represent a primary soft tissue counterpart of cutaneous malignant melanoma. Nonetheless, it is now known that CCS exhibits a consistent and characteristic t(12 22) chromosomal translocation that is not shared by mela-nocytic lesions of the skin. This neoplasm is typified by an epithelioid and/or spindle cell constituency, with a delicate fibrovascular stroma and clear or lightly eosinophilic cytoplasm. Melanin pigmentation may or may not be observed. [Pg.113]

Molecular Detection of Clear Cell Sarcoma (Malignant Melanoma of Soft Tissue)... [Pg.136]

Gandolfo N, Martinoli C, Caliero F et al (2000) Malignant melanoma of soft-tissue (clear cell sarcoma) of the foot. Is MRI able to perform a specific diagnosis Report of one case and review of the literature. Anticancer Res 20 3993-3998 Garcia J (2000) MRl in inflammatory myopathies. Skeletal Radiol 29 425-438... [Pg.92]

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