Major histocompatibility complex class proteins

Tsomides, T.J., Walker, B.D., and Eisen, H.N. (1991) An optimal viral peptide recognized by CD8+T cells binds very tightly to the restricting class I major histocompatibility complex protein on intact cells but not to the purified class I protein. Proc. Natl. Acad. Sci. USA 88, 11276-11280. 

McMenamin C, Holt PG The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class Il-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production. J Exp Med 1993 178 889-899. 

Total-body iron of a 70-kg adult is about 4.2-4A g. The distribution of iron in various body compartments is given in Table 29-1. The key players of iron metabolism include iron-responsive elements of appropriate mRNAs, iron regulatory proteins divalent metal transporter 1, major histocompatibility complex (MHC) class I-like protein designated as HFE protein, d2-microglobulin, transferrin, transferrin receptor, and ferritin. 

In a follow-up study, Smith and Hirschmann have elaborated a pyrrolinone-based mimetic of the /3-strand//3-sheet conformations [33, 34], in which all of the key recognition features (i.e., side chains and hydrogen-bond donors/acceptors) are faithfully represented within a low-molecular-weight nonpeptide analog 4 (Fig. 4.3-3). This design has been applied to the development of antagonists of HIV-1 protease and more recently to mimics of major histocompatibility complex (MHC) class II protein substrate [34, 35]. 

---