Histocompatibility proteins

Predicting binding affinities of protein ligands from three-dimensional models application to peptide binding to Class I major histocompatibility proteins. 

Dalmau J, Graus F, Cheung NK, Rosenblum MK, Ho A, Canete A, et al. Major histocompatibility proteins, anti-Hu antibodies, and paraneoplastic encephalomyelitis in neuroblastoma and small cell lung cancer. Cancer 1995 75(1) 99—109. 

Predicting Binding Affinities of Protein Ligands from Three-Dimensional Models Application to Peptide Binding to Class I Major Histocompatibility Proteins. 

MHC major histocompatibility protein RAPD random amplified polymorphic DNA... 

Aetivation of lymphocytes may be mediated by GPI anchors. T-cells are activated normally by antigen receptors binding to antigenic peptides presented in assoeiation with major histocompatibility proteins. Antibodies to GPI-anehored proteins on T-cells mimic T-cell activation by inducing cell proliferation, IL-1 and IL-2 production, and other metabolic changes in T-cells (reviewed in ref [15]). By contrast, most antibodies to other membrane components of T-cells do not activate the cells. Moreover, pretreatment of lymphocytes with PI-PLC, thereby, releasing GPI-anchored proteins, reduces the response of T-cells to antibody mitogens [161]. 

Rognan D, Laumoeller SL, Holm A, Buus S, Tschinke V. Predicting binding affinities of protein ligands from three dimensional coordinates application to peptide binding to class I major histocompatibility proteins. J Med Chem 1999 42 4650-4658. 

Bakker, T. C. M, and M. Zbinden. Counting on Immunity. Nature 414, 262-263 (2001). [An article about how, in some species, individuals select mates that have major histocompatibility proteins as dissimilar to their own as possible.]... 

Figure 17.16. Anisotropy decays for the single tryptophan residue in the tumazine protein (/op), for trp I92 in bovine cardiac troponin I (middle), and for histocompatibility protein (bcttotn). Revised from Refr.59,60, and 61.

Tector, M., and Salter, R.D. Calnexin Influences Folding of Human Class 1 Histocompatibility Proteins but not Their Assembly with P2-Microglobulin J. Biol Chem. 1995 270, 19638-19642. 

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