Chitosan grafting

Ohya et al. reported poly(ethyleneglycol)-grafted chitosan nanoparticles as peptide drug carriers. The incorporation and release of insulin was dependent on the extent of the reaction of poly(ethyleneglycol) with chitosan [190]. [Pg.175]

Depan, D., Venkata Surya, P. . C., Girrase, B., and Misra, R. D. K. (2011). Organic/inorganic hybrid network structure nanocomposite scaffolds based on grafted chitosan for tissue engineering. Acta Biomater. 7,2163-2175. [Pg.117]

Inspired by earlier work on galactose-conjugated chitosans, Hashimoto and coworkers [135] synthesized mannose-grafted chitosan (53-kDa) conjugates (man-chitosan) to deliver pDNA in mouse peritoneal macrophages that express the mannose receptor. Here, man-chitosan containing either 5% or 21%... [Pg.157]

The possibility of grafting synthetic polymer to chitosan has attracted much attention in the last years as a new way to modify the polysaccharide and develop practically useful derivatives. Graft copolymerization reactions introduce side chains and lead to the formation of novel types of tailored hybrid materials composed of natural and synthetic polymers. Grafting chitosan is a common way to improve chitosan properties such as formation of inclusion complexes [99], bacteriostatic effect [100], or to enhance adsorption properties [101, 102]. Although the grafting of chitosan modifies its properties, it is possible to retain some interesting characteristics such as mucoadhesivity [103], biocompatibility [104,105] and biodegradability [106]. [Pg.141]

Grafted chitosans have great utility in controlled drug release [115], tissue engineering [116], wound-healing [117] and cardiovascular applications [118-119]. Moreover, there are several reports regarding the use of enzymes in polymer s)m-thesis and modification [120-121]. In fact, enz)mies offer the potential advantage... [Pg.141]

Du Y-Z, Lu P et al (2010) Stearic acid grafted chitosan oligosaccharide micelle as a promising vector for gene delivery system factors affecting the complexation. Int J Pharm 391 260-266... [Pg.40]

Du Y-Z, Wang L et al (2011) Linoleic acid-grafted chitosan oligosaccharide micelles for intracellular drug delivery and reverse drug resistance of tumor cells. Int J Biol Macromol 48(l) 215-222... [Pg.40]

Hu F-Q, X-1 Wu et al (2008) Cellular uptake and cytotoxicity of shell crosslinked stearic acid-grafted chitosan oligosaccharide micelles encapsulating doxorubicin. Eur J Pharm Biopharm 69 117-125... [Pg.40]

Ouchi T, Nishizawa H et al (1998) Aggregation phenomenon of PEG-grafted chitosan in aqueous solution. Polymer 39 5171-5175... [Pg.41]

Bhattarai N, Ramay FIR et al (2005) PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release. J Control Release 103 609-624... [Pg.41]

Zhou Y-Y, Du Y-Z et al (2010) Preparation and pharmacodynamics of stearic acid and poly (lactlc-co-glycolic acid) grafted chitosan oligosaccharide micelles for 10-hydroxycamp-tothecln. Int J Pharm 393 144-152... [Pg.43]

Venkatesan, J., Qian,Z.-J., Ryu, B., Ashok Kumar, N., and Kim, S.-K. (2011a). Preparation and characterization of carbon nanotube-grafted-chitosan— Natural hydroxyapatite composite for bone tissue engineering. Carbohydr. Polym. 83,569-577. [Pg.427]

Du, Y. Z., and Wang, L. (2009). Preparation and characteristics of linoleic acid-grafted chitosan oligosaccharide micelles as a carrier for doxorubicin. Colloids Surf B., 69, 257-263. [Pg.549]

Ding, Y., Gu, G., Xia, X.-H., Huo, Q., 2009. Cysteine-grafted chitosan-mediated gold nanoparticle assembly from nanochains to microcubes. J. Mater. Chem. 19, 795—799. [Pg.144]

Bhattarai, N., Matsen, F. A. Zhang, M. (2005a) PEG-grafted chitosan as an injectable thermoreversible hydrogel. Macromol Biosci, 5, 107-11. [Pg.172]

Da Silva, R. M., Lopez-Perez, P. M., Elvira, C., Mano, J. F., Roman, J. S. Reis, R. L. (2008) Poly(iV-isopropylacrylaniide) surface-grafted chitosan membranes as a new substrate for ceU sheet engineering and manipulation. Biotechnol Bioeng, 101, 1321-31. [Pg.173]

Auzely-Velty, R. and Rinaudo, M. (2002) New supramolecultir assemblies of a cyclodextrin grafted chitosan through specific complexation. Macromolecules, 35,7955-7962. [Pg.84]

Liu C, ThormannE, ClaessonPM, Tyrode E (2014) Surface grafted chitosan gels. Part II. Gel formation and characterization. Langmuir 30 8878-8888... [Pg.238]

Radhakumary, C., Nair, P. D., Mathew, S., Nair, C.P., (2006), HEMA-Grafted Chitosan for Dialysis Membrane Applications. Journal of Applied Polymer Science,Vo. 101, No 5, (September 2006), pp 2960-2966, ISSN 1097-4628. [Pg.260]

Micelles are composed of amphiphilic block copolymers that self-assemble into spherical shapes of nanometer diameter due to energy minimization with the surrounding solvent. When exposed to a hydrophilic solvent the hydrophilic domains orient toward the solvent, while the hydrophobic domains orient toward the core and form a clump away from the solvent. In a similar manner, when amphiphilic molecules are exposed to a hydrophobic solvent they form micelles with a hydrophobic block on the surface and a hydrophilic block in the core. Micelles thus have a unique core-shell architecture composed of either hydrophobic or hydrophilic blocks depending on the chemical structures and the medium. The hydrophobic or hydrophilic core provides a reservoir for water-soluble or insoluble drugs and protects them from decomposition in order to maintain activity and stability. Stearic acid (SA)-grafted chitosan oligosaccharide (CSO-SA) formed... [Pg.448]

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