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Chitosan-TBA conjugate

FIGURE 3.1 Chemical structures of chitosan, iV-trimethyl chitosan hydrochloride, and chitosan-TBA conjugate. [Pg.58]

Guggi, D., N. Langoth, M. H. Hoffer, M. Wirth and A. Bernkop-Schnurch (2004). Comparative evaluation of cytotoxicity of a glucosamine-TBA conjugate and a chitosan-TBA conjugate. Int J Pharm 278(2) 353-360. [Pg.234]

Stronger than non-covalent bonds [89, 90]. Chitosan-TBA conjugates provide 140-fold stronger mucoadhesion than unmodified polymer [84, 86]. These favorable results can be explained by the fact that chitosan-TB A combines the formation of disulfide bonds with improved ionic interactions between the additional cationic amidine groups of the modified chitosan and the anionic moieties that are provided by sialic acid and sulfonic acid substructures in the mucus layer. Figure 6 shows the reaction scheme for the aforementioned thiolation of chitosan. [Pg.194]

Effect of Molecular Weight of Chitosan and Its TBA Conjugate on Mucoadhesive Potentials... [Pg.65]

Krauland et al. [93] prepared the microparticles with thiolated chitosan (chitosan-TBA chitosan-4-thiobutylamidine conjugate) intended for nasal peptide delivery. During the preparation process microparticles were stabilized by the formation of inter- and intramolecular cross-linking via disulfide bonds. Chitosan-TBA microparticles were characterized by improved swelling ability and displayed 3.5-fold higher insulin bioavailability compared to unmodified chitosan microparticles. [Pg.662]

Abbreviations PLGA poly(lactide-co-glycolide) P(CPP CEFB) poly[l,3-bis(p-carboxy-phenoxy) propane-co-p-(carboxyethylformamido) benzoic anhydride] chitosan-TBA chitosan-4-thiobutylamidine conjugate LPC lysophosphatidyl choline hGH human growth hormone GDC glycodeoxycholate sodium STDHF ... [Pg.673]

Thiomers Carbopol 974P-cysteine Chitosan-thioglycolic acid (TGA) Chitosan l-thio-butylamidin-conjugates (TBA)... [Pg.833]

See other pages where Chitosan-TBA conjugate is mentioned: [Pg.58]    [Pg.64]    [Pg.65]    [Pg.65]    [Pg.65]    [Pg.66]    [Pg.118]    [Pg.283]    [Pg.58]    [Pg.64]    [Pg.65]    [Pg.65]    [Pg.65]    [Pg.66]    [Pg.118]    [Pg.283]    [Pg.58]    [Pg.79]    [Pg.88]    [Pg.96]    [Pg.193]   
See also in sourсe #XX -- [ Pg.58 ]



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