Macrophages erythrocytes

The indicated biotinylated MAbs will bind CD4 CDS T cells, macrophages, erythrocytes, NK cells, granulocytes, and dendritic cells. 

Gieseg, S.P., Maghzal, G., and Glubb, D., Protection of erythrocytes by the macrophage synthesized antioxidant 7,8 dihydroneopterin. Free Radic. Res., 34, 123, 2001. Gieseg, S.P. and Cato, S., Inhibition of THP-1 cell-mediated low-density lipoprotein oxidation by the macrophage-synthesised pterin, 7,8-dihydroneopterin, Redox Rep., 8, 113, 2003. 

In 1989, we showed [142] that the Fe2+(rutin)2 complex is a more effective inhibitor than rutin of asbestos-induced erythrocyte hemolysis and asbestos-stimulated oxygen radical production by rat peritoneal macrophages. Later on, to evaluate the mechanisms of antioxidant activities of iron rutin and copper-rutin complexes, we compared the effects of these complexes on iron-dependent liposomal and microsomal lipid peroxidation [165], It was found that the iron rutin complex was by two to three times a more efficient inhibitor of liposomal peroxidation than the copper-rutin complex, while the opposite tendency was observed in NADPH-dependent microsomal peroxidation. On the other hand, the copper rutin complex was much more effective than the iron rutin complex in the suppression of microsomal superoxide production, indicating that the copper rutin complex indeed acquired additional SOD-dismuting activity because superoxide is an initiator of NADPH-dependent... 

Iron-, copper-, and zinc complexes of rutin, dihydroquercetin, and green tea epicatechins were found to be much more efficient inhibitors than parent flavonoids of toxic effects of chrysotile asbestos fibers on peritoneal macrophages and erythrocytes [168], It was proposed that in this case the enhanced activity of metal-flavonoid complexes was increased by the absorption on chrysotile fibers. 

It has been shown that lung macrophages from patients with systemic sclerosis (SS) produced the elevated levels of nitric oxide, superoxide, and peroxynitrite and expressed the enhanced level of iNOS [281], NAC administration reduced peroxynitrite production and might be possibly recommended for the treatment SS patients. Solans et al. [282] found the significant enhancement of lipid peroxidation in erythrocytes from SS patients. Cracowski et al. [283] showed that in vivo lipid peroxidation was enhanced in scleroderma spectrum disorders including SS and undifferentiated connective tissue disease. 

Proliferation/differentiation factor of haemopoietic progenitor cells, particularly those yielding neutrophils (a variety of granulocyte) and macrophages, but also eosinophils, erythrocytes and megakarycytes. In vivo studies also demonstrate this cytokine s ability to promote haemopoiesis. 

Eda, S., Kikugawa, K., and Beppu, M., 1997, Oxidatively damaged erythrocytes are recognized by membrane proteins of macrophages. Free Radio. Res. 27 23-30. 

Sambrano, G.R., Parthasarathy, P.S., and Stainberg, D., 1994, Recognition of oxidatively damaged erythrocytes by a macrophage receptor with specificity for oxidized LDL, Proc. Natl. Acad. Sci. U.S.A. 91 3265-3269. 

The synthesis of haemoglobin in the bone marrow requires about 20-25 mg of iron each day. This is obtained either from the diet or from the iron that is recycled from the degradation of senescent erythrocytes (they survive for only about 120 days) which are phagocytosed by macrophages in the liver and spleen. The iron released from the... 

About 70% of the total body store of iron (-5 g) is contained within erythrocytes. When these are degraded by macrophages of the reticuloendothelial (mononuclear phagocyte) system, iron is liberated from hemoglobin. Fe can be stored as ferritin (= protein apoferri-tin + Fe ) or returned to erythropoiesis sites via transferrin. 

In the blood, 2.5-3.0 g of hemoglobin iron circulates as a component of the erythrocytes (top right). Over the course of several months, the flexibility of the red blood cells constantly declines due to damage to the membrane and cytoskeleton. Old erythrocytes of this type are taken up by macrophages in the spleen and other organs and broken down. The organic part of the heme is oxidized into bilirubin (see p. 194), while the iron returns to the plasma pool. The quantity of heme iron recycled per day is much larger than the amount resorbed by the intestines. 

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