Macrogols glycols

Macrogol is also an osmotic laxative. Macrogol 4000 is a long linear polymer, also known as polyethylene glycol. It is not absorbed from the gut into the bloodstream, but remains in the gut where it causes water to be drawn into the lower bowel. Anaphylaxis to macrogol has been described. [Pg.384]

Constipation bulk-forming laxatives by increasing faecal mass tend to soften stools and relieve constipation, and have value in a range of symptomatic problems associated with anal fissure, haemorrhoids, and with ileostomy and colostomy dysfunction. Faecal softeners, lactulose and macrogols (polyethylene glycol) retain fluid in the bowel. Stimulant laxatives, such as the anthraquinone, senna, and bisacodyl, increase motility and can cause colic verdoses can cause diarrhea and electrolyte depletion. Chronic treatment for constipation is seldom needed, but may be in children with a tendency to faecal impaction, specialist advice should be sought. [Pg.628]

In the formulations presented here, mixtures of the polyethylene glycols, Lutrol E 400, Macrogol 1500, Macro-gol 4000, and Macrogol 6000, are intended as water-soluble base for suppositories and ovula. [Pg.529]

Benzylpenicillin is incompatible with rubber products and metal ions. Stability is affected by alcohols, surfactants, oxidizing and reducing agents, macrogols and other hydroxy compounds, glycerol, glycols, some paraffins and ointment bases, preservatives such as chlorocresol or thiomersal, blood and blood products, and antibacterials such as amphotericin, cephalosporins, and vancomycin. Injections of benzylpenicillins and aminoglycosides should be administered separately. [Pg.333]

In addition, two cases of anaphylaxis to Macrogol 6000 (polyethylene glycol) after ingestion drug tablets was observed (Hyry et al. 2006). [Pg.381]

Pharmaceutical grade poly(ethylene glycols) are poly(ethylene oxides) with terminal hydroxyl groups and have been approved by the E.D.A. and listed in both the United States Pharmacopoeia and Martindale under Macrogols for use as ointment and suppository bases (4J. Poly(ethylene glycol) can be chemically cross-linked retaining the hydrophilic nature of the PEO backbone in an infinite hydrogel network which will imbibe water and swell but not... [Pg.159]

Cetyl alchohol Cetostearyl alcohol Stearyl alcohol Stearic acid Beeswax Silica dioxide Polyethylene glycols Macrogol glycerides Poloxamers... [Pg.249]

Polyethylene Glycol Also known as macrogol, PEG is synthesized by condensation of ethylene oxide and water under suitable reaction conditions. Based on the... [Pg.272]

Polyethylene glycol 4000 or 6000 2-5 Soluble in water, moderately effective, also known as macrogols (Carbowax )... [Pg.3660]

Lubricants based on fatty acids, because of their low water solubility, are unsuitable for tablets which must be dissolved in water before use. Polyethylene glycol 6000 (macrogol 6000) is soluble in water, but its lubricant activity is limited. Magnesium lauryl sulfate has been suggested as a water-soluble substitute for magnesium stearate. In addition to its lubricant action, this substance, like sodium lauryl sulfate, is an effective wetting agent. ... [Pg.3661]

The polyoxyethylene alkyl ethers are a series of polyoxyethylene glycol ethers of n-alcohols (lauryl, oleyl, myristyl, cetyl, and stearyl alcohol). Of the large number of different materials commercially available, four types are listed in the USPNF 23, one type in the JP 2001, and four types in the PhEur 2005. BP Macrogol cetostearyl ether... [Pg.564]

The same material may also be designated polyoxyethylene glycol 400 stearate or macrogol stearate 400 in which case, the number 400 refers to the average molecular weight of the polymer chain. [Pg.585]

Ethoxylated fatty acid esters macrogol stearates Marlosol PEG fatty acid esters PEG stearates polyethylene glycol stearates poly(oxy-l,2-ethanediyl) a-hydro-to-hydroxyoctade-canoate polyoxyethylene glycol stearates. [Pg.585]

Monostearate Lipo-PEG 4-S macrogol stearate 400 Myrj 45 PEG-8 stearate Pegosperse 400 AfS polyethylene glycol 400 monostearate polyoxyethylene (8) monostearate Protamate 400-DPS Ritapeg 400 AfS. [Pg.585]

Crodet S40 E431 Emerest2672 Hodag POE [40] AfS Lipal 395 Lipo-PEG 39-S macrogol stearate 2000 Myrj 52 PEG-40 stearate polyoxyethylene glycol 2000 monostearate polyoxyethylene (40) monostearate Protamate 2000-DPS Ritox 52. [Pg.585]

A smdy of the effect of polyoxyethylene glycols on the rectal absorption of unionised sulfafurazole demonstrated the importance of the affinity of the dmg substance for base and for rectal mucosa. As the amount of Macrogol 4000 (polyoxyethylene glycol 4000) was increased, the partition coefficient (lipid/ vehicle) fell and absorption decreased correspondingly, because the affinity of the dmg for the suppository base increased and its tendency to partition to the rectal lipids decreased. In a similar way, incorporation of... [Pg.388]

Macrogols (polyethylene glycols, PEGs), are condensation polymers of ethylene oxide and water. [Pg.72]

MAA (108-31-6) see maleic anhydride. MAAC (108-84-9) see methylamyl acetate. MACH-NIC (54-11-5) see nicotine. MACROGOL 400 BPC (107-21-1) see ethylene glycol. [Pg.641]

CAS 112-60-7 25322-68-3 (generic) EINECS/ELINCS 203-989-9 Synonyms Bis [2-(2-hydroxyethoxy) ethyl] ether 2-[2-(2-(2-Hydroxyeth-oxy) ethoxy) ethoxy] ethanol Macrogol 200 2,2 -[Oxybis (2,1-ethanediyloxy)] bisethanol 2,2 -(Oxybis (ethyleneoxy)) diethanol PEG 200 POE (4) TEG Tetraethylene glycol Tetraglycol Definition Polymer of ethylene oxide Empirical CiHuOs Formula H(OCH2CH2),OH... [Pg.1242]

Synonyms Hexaethylene glycol Macrogol 300 PEG 300 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol Polyethylene glycol 300 Definitkm Polymer of ethylene oxide En xrical C HjeO,... [Pg.1242]

CAS 25322-68-3 (generic) EINECS/ELINCS 203-989-9 Synonyms Macrogol 1000 PEG 1000 POE (20) Polyethylene glycol 1000 Polyglycol 1000 Definition Polymer of ethylene oxide Empirical C40H82O21... [Pg.1243]

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