Polyoxyethylene glycols Macrogols

Reproduced from A. Hoelgaard and N. Muller, Arch. Pharm. Chem., 3, 34 (1975). 

Use of polyoxyethylene glycols, and other hydrophilic polymers, in high concentrations 

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The polyoxyethylene alkyl ethers are a series of polyoxyethylene glycol ethers of n-alcohols (lauryl, oleyl, myristyl, cetyl, and stearyl alcohol). Of the large number of different materials commercially available, four types are listed in the USPNF 23, one type in the JP 2001, and four types in the PhEur 2005. BP Macrogol cetostearyl ether... 

The same material may also be designated polyoxyethylene glycol 400 stearate or macrogol stearate 400 in which case, the number 400 refers to the average molecular weight of the polymer chain. 

Ethoxylated fatty acid esters macrogol stearates Marlosol PEG fatty acid esters PEG stearates polyethylene glycol stearates poly(oxy-l,2-ethanediyl) a-hydro-to-hydroxyoctade-canoate polyoxyethylene glycol stearates. 

Crodet S40 E431 Emerest2672 Hodag POE [40] AfS Lipal 395 Lipo-PEG 39-S macrogol stearate 2000 Myrj 52 PEG-40 stearate polyoxyethylene glycol 2000 monostearate polyoxyethylene (40) monostearate Protamate 2000-DPS Ritox 52. 

A smdy of the effect of polyoxyethylene glycols on the rectal absorption of unionised sulfafurazole demonstrated the importance of the affinity of the dmg substance for base and for rectal mucosa. As the amount of Macrogol 4000 (polyoxyethylene glycol 4000) was increased, the partition coefficient (lipid/ vehicle) fell and absorption decreased correspondingly, because the affinity of the dmg for the suppository base increased and its tendency to partition to the rectal lipids decreased. In a similar way, incorporation of... 

Monostearate Lipo-PEG 4-S macrogol stearate 400 Myrj 45 PEG-8 stearate Pegosperse 400 AfS polyethylene glycol 400 monostearate polyoxyethylene (8) monostearate Protamate 400-DPS Ritapeg 400 AfS. 

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