Macrogol

Macrogol is also an osmotic laxative. Macrogol 4000 is a long linear polymer, also known as polyethylene glycol. It is not absorbed from the gut into the bloodstream, but remains in the gut where it causes water to be drawn into the lower bowel. Anaphylaxis to macrogol has been described. 

Gnest JF, Varney SJ. Pharmacoeconomic impact of low-dose macrogol 3350 plus electrolytes compared with lactulose in the management of chronic idiopathic constipation among ambnlant patients in Belginm. Chn Dmg Investig 2004 24(12) 719-29. 

Constipation bulk-forming laxatives by increasing faecal mass tend to soften stools and relieve constipation, and have value in a range of symptomatic problems associated with anal fissure, haemorrhoids, and with ileostomy and colostomy dysfunction. Faecal softeners, lactulose and macrogols (polyethylene glycol) retain fluid in the bowel. Stimulant laxatives, such as the anthraquinone, senna, and bisacodyl, increase motility and can cause colic verdoses can cause diarrhea and electrolyte depletion. Chronic treatment for constipation is seldom needed, but may be in children with a tendency to faecal impaction, specialist advice should be sought. 

Carbomer, carmellose, microcrystalline cellulose, sodium carboxymethylcellulose, povidone, sodium alginate, tragacanth, and xanthan gum Acacia and methylcellulose, glycerol esters, polysorbates and sorbitan esters, fatty acids, sodium stearate, carbomer Macrogol esters, polyvinyl alcohol, and glycerides... 

Dissolve the sucrose, Kollidon VA64 and Macrogol 4000 in the water and suspend the other components. Pass through a colloid mill. 

In the formulations presented here, mixtures of the polyethylene glycols, Lutrol E 400, Macrogol 1500, Macro-gol 4000, and Macrogol 6000, are intended as water-soluble base for suppositories and ovula. 

Dissolve macrogol 4000 in the hot mixture of glycerol and water and add the glucose warmed to 60-80 °C. Incorporate solution (I) in the obtained paste. 

Melt the macrogols by gentle heating. Stir in the micronized PVP-lodine product in small portions into the melt. 

Dissolve butylhydroxytoluene in the warm vitamin A, add Cremophor and mix with the molten macrogols. 

Benzylpenicillin is incompatible with rubber products and metal ions. Stability is affected by alcohols, surfactants, oxidizing and reducing agents, macrogols and other hydroxy compounds, glycerol, glycols, some paraffins and ointment bases, preservatives such as chlorocresol or thiomersal, blood and blood products, and antibacterials such as amphotericin, cephalosporins, and vancomycin. Injections of benzylpenicillins and aminoglycosides should be administered separately. 

Lactose monohydrate, corn starch, modified starch, povidone 25000, magnesium stearate, HPMC, Macrogol 6000, talc, titanium dioxide, ferric oxide pigment, yellow NF... 

Hyry, H., Vuorio, A., Varjonen, E., Skytta, I., and Makinen-Kiljunen, S. 2006. Two cases of anaphylaxis to macrogol 6000 after ingestion of drug tablets. Allergy 61(8) 1021. 

Recently the cases of severe allergic reactions to yeast, buckwheat, and macrogol were identified in Finland—patent blue and carmine dye have been noted in Finland (Airola et al. 2006, Makinen-Kiljunen and Flaahtela 2008). 

In addition, two cases of anaphylaxis to Macrogol 6000 (polyethylene glycol) after ingestion drug tablets was observed (Hyry et al. 2006). 

Pharmaceutical grade poly(ethylene glycols) are poly(ethylene oxides) with terminal hydroxyl groups and have been approved by the E.D.A. and listed in both the United States Pharmacopoeia and Martindale under Macrogols for use as ointment and suppository bases (4J. Poly(ethylene glycol) can be chemically cross-linked retaining the hydrophilic nature of the PEO backbone in an infinite hydrogel network which will imbibe water and swell but not... 

Cetyl alchohol Cetostearyl alcohol Stearyl alcohol Stearic acid Beeswax Silica dioxide Polyethylene glycols Macrogol glycerides Poloxamers... 

Polyethylene Glycol Also known as macrogol, PEG is synthesized by condensation of ethylene oxide and water under suitable reaction conditions. Based on the... 

These compounds, which are mixtures of condensation products of ethylene oxide and water (macrogols), are used as solvents for a variety of pharmaceutical preparations, including some ste-... 

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