Lymphoid cells morphology

Mantle cell lymphoma cells are generally small to medium-sized lymphoid cells with variably irregular nuclear contours and a scant amount of cytoplasm. Morphologically, MCL cells can be difficult to distinguish from those of CLL/SLL,... 

This uncommon lymphoma morphologically consists of a mixture of lymphoid cells, plasma cells, and cells sharing the characteristics of both lymphocytes and plasma cells. Mast cells are quite prominent. Plasma-cytoid features may take the form of Dutcher bodies, as well as Russell bodies, which may be enhanced by staining with PAS. The typical presentation for this lymphoma is bone marrow involvement with little nodal or spleen involvement. These lymphomas typically present with a monoclonal gammopathy of IgM and its associated hyperviscosity and/or cryoglobulinemia (Waldenstrom macroglobulinemia). An association with hepatitis C has been noted with this lymphoma. 

Steinman RM, Cohn ZA Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med 1973 137 1142-1162. 

Lymphocytes are one of the primary cell types involved in the immune response. There are two general types of lymphocytes, B and T. Both are derived from bone marrow lymphoid stem cells, but T cells go through an additional maturation process in the thymus. Although the morphology of T cells and B cells is similar, the functions of these two types are distinct. After antigen exposure, B cells develop into antibody-producing plasma cells, whereas T cells are divided into functional subtypes that possess distinct cell surface antigens. 

Nzze H, Cogliatti SB, von Schilling C, et al. Monocytoid B-cell lymphoma morphological variants and relationship to low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue. Histopathology. 1991 18(5) 403-414. 

Makori N,Tarantal AF, Lii EX, Ronrke T, Mathas ML, McChesney MB, Hendrickx AG, Miller CJ. Functional and morphological development of lymphoid tissues and immune regulatory and effector fnnction in Rhesus monkeys cytokine-secreting cells, immunoglobulin-secreting cells, and CD5+ B-1 cells appear early in fetal development. Clin Diag Lab Immnnol 2003 10 140-153. 

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