Lymphocytic tumors

IL-2+ LAK cell or tumor infiltrating lymphocyte tumor destmction rodent and human... 

Retroviruses Human T-cell leukemia virus (HTLV) Human T-lymphocytic tumors... 

Abelson Virus-Induced Lymphocytic Tumors. Abelson virus (A-MuLV or MuLV-A) is a type C RNA virus (25) and exists in the murine leukemia virus complex. This is a defective virus and contains the Moloney leukemia virus helper component and a replication-defective Abelson component (23) that transforms lymphocytes and 3T3 fibroblasts. While Abelson virus is not... 

Lymphocyte Tumor Type Computer Name Characteristics Induction Condition... 

Bone marrow lymphocytic tumors ABLS-1 ABLS-140 e (leukogenic) Abelson virus (C-type RNA)... 

Lymphocytic Tumors of Thymic Origin. The appearance of spontaneous tumors (e. . SAKRTLS-13) in AKR and C58 mice (27) is quite common. Other thymic tumors can also be induced chemically (28) (BALENTL—3, -5 or P-1798 Table I) or virally (Moloney leukemia virus (29)). in the early stage of tumor development they are confined to the thymus, but later the tumor is metastasized to the spleen, liver, kidney, and lymph nodes. 

The problem is that if an individual antibody-producing cell is isolated and grown in culture, its descendants have a limited lifespan that severely limits their use for the routine preparation of monoclonal antibodies. In 1975, Milstein and Kohler discovered how monoclonal antibodies of almost any desired antigen specificity can be produced indefinitely and in large quantities. Their method was to fuse a B lymphocyte producing antibody of the desired specificity with a cell derived from a cancerous lymphocyte tumor, called a myeloma cell, which is immortal. The cell fusion is called a hybridoma, which is both immortal and secretes the same specific antibody originally encoded by the B lymphocyte. 

The production in vitro of mAbs with a predetermined specificity has only been possible since the advent of the technology of hybridomas, which was introduced by Kohler and Milstein in 1975. These hybridomas are the products of in vitro fusion of myelomas with normal B lymphocytes. The fusion products preserve the capacity for self-propagation in a culture, as well as the secretion of the antibodies of interest, characteristics inherited from the parent myeloma and the normal B lymphocyte, respectively. The myelomas used in such fusions generally involve cell lines from B-lymphocyte tumors developed in mice or rats (Cotton and Milstein, 1973 Kohler and Milstein, 1975b Shulman et al., 1978), while... 

Monoclonal antibodies are produced by hybrid cells created from B lymphocytes fused with immortal B lymphocyte tumor cells. The resulting hybrids can be individually cloned, and each clone will produce antibodies directed against a single antigen type. Two new monoclonal antibody types have been created that are useful in the treatment of cancer. 

Hawley, R. S., Friend, S. H. (1996) Strange bedfellows in even stranger places The role of ATM in meiotic cells, lymphocytes, tumors and its functional links to p53. Genes Dev. 10 2383. 

Hattori, Y. Odagiri, H. Katoh, O. Sakamoto, H. Morita, T. Shimotohno, K. Tobinai, K. Sugimura, T. Terada, M. K-sam-related gene, N-sam, encodes fibroblast growth factor receptor and is expressed in T-lymphocytic tumors. Cancer Res., 52, 3367-3371 (1992)... 

Hybridoma Cultured cell line that results from the fusion of an antibody-making B lymphocyte and a myeloma (B lymphocyte tumor cell) that secretes a monoclonal antibody. 

CELL MEDIATED CYTOTOXICITY STIMULATED IN AN ALLOGENIC MIXED LYMPHOCYTE TUMOR REACTION (MLTR-CMC) ASSAY... 

Raingeaud, J., Gupta, S., Rogers, J. S., Dicken, M., Han, J., Ulevitch, R. J., and Davis, R. J. (1995). Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270, 7420-7426. Garrett, T. A., Rosser, M. F. N., and Raetz, C. R. H. (1999). Signal transduction triggered by lipid A-like molecules in 70Z/3 pre-B lymphocyte tumor cells. Biochem. Biophys. ACTA, in press. 

Rivoltini, L., Carrabba, M., Huber, V., Castelli, C., Novellino, L., Dalerba, P., Mortarini, R., Arancia, G., Anichini, A., Fais, S., and Parmiani, G. (2002). Immunity to cancer Attack and escape in t lymphocyte-tumor cell interaction. Immunol. Rev. 188,97-113. 

Espada, C.E., Berra, M.A., Martinez, M.J., Eynard, A.R., Pasqualini, M.E., 2007. Effect of Chia oil (Salvia hispanica) rich in omega-3 fatty acids on the eicosanoid release, apoptosis and T-lymphocyte tumor infiltration in a murine mammary gland adenocarcinoma. Prostaglandins Leukot. Essent. Fatty Acids 77, 21-28. 

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