Lymphocytes phenotype

Peakman, M., et al. Analysis of lymphocyte phenotypes in cord blood from early gestation fetuses, Clin. Exp. Immunol., 90, 345, 1992. 

Wooley, P.H., and Whalen, J.D. Pristane-induced arthritis in mice. III. Lymphocyte phenotypic and functional abnormalities precede the development of pristane-induced arthritis. Cell. Immunol., 138, 251, 1991. 

Rat once (Fischer-344) (GO) 1 (alterations in lymphocyte phenotypes) Gehrsetal. 1979a... 

Platanias L, Gascon P, Bielory L, et al. Lymphocyte phenotype and lym-phokines following anti-lymphocyte globuUn therapy in patients with aplastic anemia. Br J Haematol 1987 66 437-443. 

Huraib, S. et al. (1998) Effect of intravenous alfacalddol on lymphocyte phenotyping in hemodialysis patients. American Journal of Kidney Diseases, 32, 1036-1040. 

Berrih-Aknin S, Safar D, Cohen-Kaminsky S. Analysis of lymphocyte phenotype in human thymomas. Adv Exp Med Biol. 1988 237 369-374. 

TABLE 2.1-1 Lymphocyte Phenotypes in Peripheral Blood Spragne-Dawley Rats and Cynomoigns Monkeys... 

Lymphocyte Phenotyping in Developmental and Juvenile Toxicity Studies... 

Low levels or absence of adenosine deaminase (ADA) is associated with one form of severe combined immunodeficiency disease (SCID) characterized by B-andT-lymphocyte dysfunction due to toxic effects of deoxyadenosine (HI9). Most patients present as infants with failure to thrive, repeated infections, severe lymphopenia, and defective cellular and humoral immunity. Disease severity is correlated with the degree of deoxyadenosine nucleotide pool expansion and inactivation of S-adenosylhomocysteine hydrolase in red blood cells. Up to now, more than 40 mutations have been identified (A4, H20, S5, S6). The majority of the basic molecular defects underlying ADA deficiency of all clinical phenotypes are missense mutations. Nonsense mutations, deletions ranging from very large to single nucleotides, and splicing mutations have also been reported. It is likely that severe... 

Fischbein A, Tsang P, Luo J-CJ, et al. 1993. Phenotypic aberrations of CD3+ and CD4+ cells and functional impairments of lymphocytes at low-level occupational exposure to lead. Clin Immunol Immunopathol 66 163-168. 

The effects of Pb on the mixed lymphocyte response (MLR) have been examined in prior studies. McCabe and colleagues [53] and Farrer and colleagues [54] demonstrated that Pb in vitro at very low concentrations (0.1 pM = 2 pg/dL) significantly enhanced the proliferation and expansion of murine alloreactive CD4+ T lymphocytes in the MLR. The expanded T cell population was found to have a high density of CD4 molecules on the cell surface making them phenotypically similar to memory/effector T lymphocytes. In a study using Lewis strain rats, Razani-Boroujerdi and coworkers [55] also found evidence for Pb-induced stimulation of the in vitro MLR. 

De Guise, S. et al., Phenotyping of beluga whale blood lymphocytes using monoclonal antibodies, Develop. Comp. Immunol., 21, 425, 1997. 

The initiation and maintenance of IgE antibody responses are regulated by, and dependent upon, the generation of T lymphocyte responses of the correct (Th2-type) phenotype. These cells produce type 2 cytokines (including interleukins (IL) 4, 5, and 13) that collectively facilitate IgE antibody production, and that participate importantly in the elicitation of IgE-mediated allergic reactions [34-36],... 

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