Lymphocyte large

Collins, A. R., Gedik, C. M., Olmedilla, B., Southon, S., and Bellizzi, M. (1998). Oxidative DNA damage measured in human lymphocytes Large differences between sexes and between countries, and correlations with heart disease mortality rates. FASEB J. 12 1397-1400. 

The subcapsular cortex is the primary site of thymic lymphocytopoiesis and a major zone for eolonization of stem cells (or pre-T cells) emigrating from the yolk sac, fetal liver, or other sites. During embryogenesis, the first thymic lymphocytes, large basophilic blast cells, are observed in this area and a certain number of such cells are usually found here in the normal thymus. Most cells in the subcapsular cortex are large lymphocytes and they... 

A B lymphocyte is a specific type of white blood cell (leucocyte) derived from bone marrow stem cells. Each B lymphocyte expresses an immunoglobulin (antibody) specific for a particular antigen. Following antigenic stimulation, a B lymphocyte may differentiate and multiply into plasma cells that secrete large quantities of monoclonal antibody. 

Immunosuppressive drugs comprise a large spectrum of substances with different mechanisms of action where T-lymphocytes represent a major target [1, 2]. In general, immunosuppressants can be divided into those that... 

Large granular lymphocytes, not belonging to either the T- or B-cell lineage. Natural killer (NK) cells are considered part of the innate defense system since, in contrast to cytotoxic T-cells, they are able to kill certain tumor cells in vitro without prior sensitization. The basal activity of NIC cells increases dramatically following stimulation with type I IFNs. In addition, NK cells display Fc-receptors for IgG and are important mediators of Antibody-Dependent-Cell-mediated-Cytotoxicity (ADCC). 

The lymphocytes from 31 patients exposed to various organophosphate pesticides were examined for chromosomal aberrations (Van Bao et al. 1974). Five of the patients were exposed to methyl parathion only. Blood samples were taken 3-6 days after exposure and again at 30 and 180 days. A significant (p<0.05) increase was noted in the frequency of stable chromosomal aberrations in acutely intoxicated persons (although such cells are eventually lost from the cell population). Two of the methyl parathion-exposed persons had taken large doses orally in suicide attempts. The study limitations include small sample size, absence of a control group, lack of quantification of exposure levels, and possible... 

A large number of cells are involved in the immune response and all are derived fiom the multipotential stem cells of the bone marrow. The predominant cell is the lymphocyte but monocytes-macrophages, endothelial cells, eosinophils and mast cells are also involved with certain immune responses. The two types of immunity (humoral and cell-mediated) are dependent on two distinct populations of lymphocytes, the B cells and the T cells respectively. Both the humoral and the cell-mediated systems interact to achieve an effective immune response. 

NK cells are a subset of lymphocytes found in blood and lymphoid tissues, especially the spleen. They are about 15 an in diameter, possess a kidney-shaped nucleus and have two or three large granules in the cytoplasm. They are derived from the bone marrow. NK cells have the ability to kill certain tumour lines and normal cells infected by virus. Killing by NK cells is not specific for viral antigenic epitopes, and is not restricted by MHC molecules. They do not possess CD3 but do express CD2, CD 16 and CD56, together with a low-affinity receptor for the Fc portion of IgG. 

Cl -channels with large, intermediate, and small conductance have been found in apolar non-excitable cells. In macrophages and in fibroblasts large Cl -channels were found [33,44]. The latter preparation, lymphocytes, monocytes and keratino-cytes also contain an intermediate conductance outwardly rectifying Cl -channel... 

LG j8-Lact< obulin LGL Large granular lymphocyte LH Luteinizing hormone LHRH Luteinizing hormonereleasing hormone LI Labelling index LIS Lateral intercellular spaces LMP Low molecular mass polypeptide... 

T lymphocytes become activated over the course of 3 to 4 weeks, producing interferon-y (IFN-y) and other cytokines. These stimulate microbicidal macrophages to surround the tuberculous foci and form granulomas to prevent further extension.15 At this point, the infection is largely under control, and bacillary replication falls off dramatically. Any remaining mycobacteria are believed to reside primarily within granulomas or within macrophages that have avoided detection and lysis. Over 1 to... 

The pathophysiology of HL is defined by the presence of the RS cell in a grouping of lymph nodes. The RS cell is a large cell morphologically with a multinucleated structure with pronounced eosinophilic nucleoli.5 In the affected lymph nodes, the RS cells are contained in a reactive milieu of T lymphocytes, eosinophils, histiocytes, and plasma cells, which makes them difficult to distinguish from these background cells. The natural course of the disease, if left untreated, is less than a 5% probability of surviving 5 years. 

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