Thymic lymphocytes

Ganapathy et al. [18] showed that the human placental brush border Na" /H exchanger (a sensitive-type) was also inactivated by DEPC, and amiloride protected against inhibition. DEPC also inactivated the sensitive-type Na /H exchanger in thymic lymphocytes [19]. 

Gershon RK, Kondo K CeU interactions in the induction of tolerance the role of thymic lymphocytes. Immunology 1970 18 723-737. 

Class Immunosuppressant gamma globulin, primarily monomeric IgG, from hyperimmune serum of horses immunized with human thymic lymphocytes... 

Lymphoid Elements. The thymus plays a central role in the differentiation of T lymphocytes (Cantor and Weissman, 1976), and although much recent emphasis has focused on the thymic epithelial cells, it must be emphasized that the thymus is a lymphoid structure composed predominantly of thymic lymphocytes or thyntocytes. The thymus can be viewed as a solid epithelial organ, penetrated by blood vessels and infiltrated with thymocytes in four discrete areas the subcapsular cortex, the inner cortex, the medulla, and the perivascular connective tissue. 

The subcapsular cortex is the primary site of thymic lymphocytopoiesis and a major zone for eolonization of stem cells (or pre-T cells) emigrating from the yolk sac, fetal liver, or other sites. During embryogenesis, the first thymic lymphocytes, large basophilic blast cells, are observed in this area and a certain number of such cells are usually found here in the normal thymus. Most cells in the subcapsular cortex are large lymphocytes and they... 

Morris DL, Komoesar WJ. Immunophenotyping analysis of peripheral blood, splenic, and thymic lymphocytes in male and female rats. J Pharmacol Toxicol Methods 1997 37 37 6. 

Cortical thymic lymphocytes, ovarian granulosa cells, pancreatic islets, Sertoli cells, endothelial cells, T-cells and activated B-cells, ependymal cells... 

Table 5. Repair of DNA strand breaks and cell proliferation in splenic and thymic lymphocytes after mitogen treatment...

We propose a model in which there is a continuous production and repair of DNA strand breaks in resting and Con A-stimulated mouse lymphocytes as well as in resting and Con A plus interleukin 2-stimulated thymocytes. A change in the steady state level of these breaks soon after stimulation occurs in the splenic but not thymic lymphocytes this change is probably due to a transient increase in rate of repair, due to a rapid but transient increase in internal concentration of NAD", the substrate of the poly(ADP-ribose) polymerase. This shift in steady state is necessary but not sufficient for the initiation and maintenance of the proliferative response. 

By using a sensitive immunoperoxidase technique, serological determinants to terminal deoxy-nucleotidyl transferase (EC 2.7.7.31)were found in cortical lymphocytes of thymus biopsies of adult and aged persons (21-70 years) of either sex (Steinmann and Muller-Hermelink 1984). In contrast to biochemical determinations, specific immunohistological studies showed that terminal deoxynucleotidyl transferase is continuously pre-snent in very large numbers of cortical thymic lymphocytes during human life, despite subtotal physiological involution of the thymus. 

While cAMP hyperpolarizes the postsynaptic membrane, cGMP depolarizes it. At least some of the hormonal action can be mimicked provided that low doses of cGMP are used. Thus while 10" M cGMP elicits acetylcholinelike effects on heart cells in culture, 10 M cGMP stimulates DNA synthesis in thymic lymphocytes, 10" enhances chemotaxis toward human lymphocytes. 

Franks, D. J., and MacManus, J. P., 1971, Cyclic GMP stimulation and inhibition of cyclic AMP phosphodiesterase from thymic lymphocytes, Biochem. Biophys. Res. Commun. 42 844. 

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