Lubricants polyethylene glycol

Aim of the selection of the varied additive types was the use of pure substances as binders (polyvinyl alcohol Mowiol 4-88 ), lubricants (polyethylene glycol PEG 400 ), and dispersants (sodium polyacrylate NaPA 8000 ) to see responsible additive components for suspension property and stmcture changes. The study of the influencing parameter additive type is completed with investigations using commercially available and considerable additive systems (Tylose H15YG4, Duramax BIOOO). 

Coupling agents such as hydroxymethyl benzene or a polyoxyeth-ylene-polyoxypropylene ether [polypropylene glycol-polyethylene glycol ether, POE-POP ether, e.g., Ucon synthetic lubricant from Union Carbide Corp.)] and hydrotropes, such as an imidazoline car-boxylate may also be needed to hold the formulation together. 

Cellulosic, polyester, and acrylic fibers lubricated with a surfactant-based oiling composition containing an organic phosphorus ester neutralized with an amine showed less pilling, good antistatic properties, and anticorrosiveness. The phosphorus ester salts were hexyl phosphate trimethylamine salt, dodecamethy-lene caproate phosphonate ethylamine salt, and polyethylene glycol dodecyl ether phosphate dimethylamine salt [262]. 

The most effective lubricants are the hydrophobic stearates, such as magnesium stearate, calcium stearate, and stearic acid. Magnesium stearate is the most widely used lubricant [117,118]. Lubricants proposed as being less hydrophobic such as hydrogenated vegetable oils, polyethylene glycols, and sodium stearyl fumarate are less effective in this application [118]. 

For lubricants such as polyethylene glycol, the molecular weight distribution can be studied using LC-MS with positive APCI (Figure 22). 

Lubricants are used in tablet preparation and include magnesium stearate, stearic acid and polyethylene glycol. They only comprise at most 1-2% of the tablet bulk so that their potential to interfere is slight, particularly since their chromophores are weak. The fatty acid lubricants can often be observed if analysis of a tablet extract is carried out by GC-FID. Tablet coatings are often based on modified sugar polymers such as hydroxypropylmethylcellulose. These coatings are used at about 3% of the tablet bulk, are water soluble and do not absorb UV light. 

Jin, C.-M., Ye, C., Phillips, B.S., Zabinski, J.S., Liu, X., Liu, W., and Shreeve, J.M., Polyethylene glycol functionalized dicationic ionic liquids with alkyl or poly-fluoroalkyl substituents as high temperature lubricants,. Mater. Chem., 16, 1529-1535, 2006. 

Polyoxyethylene fatty acid esters are produced by the reaction of polyethylene glycols with fatty adds. The commercial products are waxy solids which include Carbowax 4000 (Mono) Stearate. Some of the products act as plasticizers and lubricants for plastics. The polyethylene glycols are soluble in water. 

Lubricants Magnesium stearate, stearic acid, polyethylene glycol, sodium chloride... 

Rotthauser, B., Kraus, G., and Schmidt, P. C. (1998), Optimization of an effervescent tablet formulations containing spray-dried L-leucine and polyethylene glycol 6000 as lubricants using a central composite design, Eur. J. Pharm. Biopharm., 46, 85-94. 

Polyethylene glycol 4000 2-20 soluble Soluble, poorer lubricant activity than fatty acid... 

Glidants and lubricants boric acid, colloidal silica, hydrogenated vegetable oils, magnesium stearate-polyethylene glycols, stearic acid, talc. 

Systane (Alcon) Polyethylene glycol 400, propylene glycol, HP-Guar Balances pH forms a lubricating gel on contact with ocular surface and reported to reduce ocular inflammatory changes. Longer lasting formulation as compared with traditional formulations and can be dosed every 8 hours. 

Watei oluble ointments include mixtures of mac-rogols and polyethylene glycols their consistency can be varied readily. They are easily washed off and are used in bum dressings, as lubricants and as vehicles that readily allow passage of dmgs into the skin, e.g. hydrocortisone. 

Polyethylene glycol Lubricant 2-5 M.W. 4000-6000, soluble in water, moderately effective... 

A combination of 4% polyethylene glycol (PEG) 6000 and 0.1% sodium stearyl fumarate proved to be a good lubricant for ascorbic acid tablets made by direct compression on a small scale. Sodium chloride, sodium acetate, and D,L-leucine (water-soluble lubricants) also have been suggested for effervescent tablets. ... 

L-leucine and polyethylene glycol 6000 as lubricants using a central composite design. Sur. J. Pharm. Sci. 1998, 46, 85-94. 

Lubricants based on fatty acids, because of their low water solubility, are unsuitable for tablets which must be dissolved in water before use. Polyethylene glycol 6000 (macrogol 6000) is soluble in water, but its lubricant activity is limited. Magnesium lauryl sulfate has been suggested as a water-soluble substitute for magnesium stearate. In addition to its lubricant action, this substance, like sodium lauryl sulfate, is an effective wetting agent. ... 

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