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LTC4

The carbon sulfur bond in LTC4 is formed by the reaction of glutathione (Section 15 13) with leukotriene A4 (LTA4) LTA4 is an epoxide Sug gest a reasonable structure for LTA4... [Pg.1082]

Leukotrienes. Leukotrienes, products of the Hpoxygenase pathway, are generally less radioprotective than the PGs, with the exception of LTC4, which is among the most potent of the naturally occurring eicosanoids (214). LTC radioprotects V79 hamster cells in vitro and mouse CEU-S and... [Pg.497]

Oxido analog of LTA4 and the corresponding analogs of LTC4 and LTD4 (Ref. 1) ... [Pg.331]

MRP2 (ABCC2) LTC4, bilirubin-glucuronide, estradiol 17 3-glucuronide, dianionic bile salts, anionic conjugates, glutathione disulfide, and others... [Pg.7]

This is the enzyme that converts Leukotriene C4(LTC4) to Leukotriene D4 (LTD4) upon its secretion from inflammatory cells. [Pg.553]

Nomenclature BUT, receptor CysLT, receptor (LTD4 receptor) CysLT2 receptor (LTC4 receptor)... [Pg.688]

These studies showed that immunologically activated HHMC release PGD2 and LTC4. Interestingly, intravenous and intracoronary injection of traces of LTC4 and LTD4 may have several cardiovascular and metabolic effects [32]. [Pg.101]

Soter, N.A., Lewis, R.A., Corey, E.J. and Austen, K.F. (1983). Local effects of synthetic leukotrienes (LTC4, LTD4, LTE4 and LTB4) in human skin. J. Invest. Dermatol. 80, 115-119. [Pg.124]

Wenzel, S.E., Lauren, G.L., Johnston, K., Voelkel, N.F. and Westcott, J.Y. (1990). Elevated levels of LTC4 in bronchoalveolar lavage fluid from atopic asthmatics after endobronchial allergen challenge. Am. Rev. Resp. Dis. 142, 112-119. [Pg.231]

LTA4, LXB4, LTC4, LTD4, LTE4 Leukotrienes A4, B4, C4, D4 and Ej Ly-1 (Cell line)... [Pg.284]

Melatonin (ML1A, ML1B) Dopamine (Dl, D2, D4, D5) y-Amino butyric acid (GABAB) Leukotrienes (LTB4, LTC4, LTD4)... [Pg.34]

Compound 508 (PNRI-299), a small molecule /3-strand mimetic template compound, is active as an inhibitor of the multifunctional activating protein factor 1 (AP-1). PNRI-299 has demonstrable effects on the reduction of API-driven transcription and beneficial pharmacological effects in a mouse asthma model. The compound affects the expression of leukotriene C4 (LTC4) synthase, a crucial enzyme for the formation of the cysteinyl leukotrienes <2003PNA1169, 2004MI211>. [Pg.464]

Anderson W, Kalberg C, Edwards L et al. Effects of polymorphisms in the promoter region of 5-lipoxygenase and LTC4 synthase on the clinical response to Za-firlukast and Fluticasone. Eur Respir J 2000 16 183s. [Pg.233]

Soon after, the complete structure of SRS-A was finally determined by total synthesis. SRS-A turned out to be a mixture of 3 substances now known as leukotriene C4 (LTC4), leukotriene D4 (LTD4) and leukotriene E4 (LTE4) in which LTD4 was predominant. The jump from a biological observation in 1938 to a molecular structure of LTD4 opened the door to a novel and selective treatment for asthma. The theory was that if one... [Pg.106]

See other pages where LTC4 is mentioned: [Pg.1082]    [Pg.388]    [Pg.312]    [Pg.313]    [Pg.318]    [Pg.318]    [Pg.331]    [Pg.332]    [Pg.1082]    [Pg.288]    [Pg.685]    [Pg.685]    [Pg.686]    [Pg.686]    [Pg.686]    [Pg.687]    [Pg.687]    [Pg.688]    [Pg.689]    [Pg.178]    [Pg.23]    [Pg.98]    [Pg.99]    [Pg.101]    [Pg.104]    [Pg.135]    [Pg.178]    [Pg.295]    [Pg.197]    [Pg.223]    [Pg.224]    [Pg.106]    [Pg.31]   
See also in sourсe #XX -- [ Pg.659 , Pg.660 , Pg.663 ]



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5.12- LTC4, synthesis

Inhibition of LTC4-release

LTC4 (leukotriene

LTC4 synthase

LTC4 synthase deficiency

Leukotrienes (LTC4, LTD4, and

Leukotrienes LTC4 type

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