Asthma mouse

Wuyts A, Overbergh L, Mathieu C, Ceuppens JL Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am J Respir Cell Mol Biol 2003 28 42-50. 

In addition to the NOD mouse, Entelos has models for several human metabolic diseases (diabetes, obesity, and metabolic syndrome), inflammatory diseases (rheumatoid arthritis), and respiratory diseases (asthma and COPD). 

Iwamura and Ueda [386] described compound (611) as a CB2 selective inverse agonist in a patent application. The potential therapeutic roles of CB2 antagonists are not clearly defined at the moment, although roles in regulation of the immune system and inflammation have been widely proposed. This patent application describes that activity of compound (611) in a mouse model of asthma, in which the compound suppressed immediate and late-phase asthmatic response and airway hyper-responsiveness. 

Compound 508 (PNRI-299), a small molecule /3-strand mimetic template compound, is active as an inhibitor of the multifunctional activating protein factor 1 (AP-1). PNRI-299 has demonstrable effects on the reduction of API-driven transcription and beneficial pharmacological effects in a mouse asthma model. The compound affects the expression of leukotriene C4 (LTC4) synthase, a crucial enzyme for the formation of the cysteinyl leukotrienes <2003PNA1169, 2004MI211>. 

Viana, M.E., et al., An extract of Stachybotrys chartarum causes allergic asthma-like responses in a BALB/c mouse model, Toxicol. Sci., 70, 98, 2002. 

Zosky G, Sly P, Turner D Mouse models of asthma what physiological evidence are they based on Allergy Clin Immunol Int J World Allergy Org 2006 18 76-79. 

Van Rijt LS, Vos N, Willart M, Kleinjan A, Coyle AJ, Hoogsteden HC, Lambrecht BN Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma. J Allergy Clin Immunol 2004 114 166-173. 

Vermaelen K, Cataldo D, Tournoy KG, Maes T, Dhulst A, Louis R, Foidart J-M, Noel A, Pauwels RA Matrix metallo-proteinse-9-mediated dendritic cell recruitment into the airways is a critical step in mouse model of asthma. J Immunol 2003 171 1016-1022. 

Li J, Luo L, Wang X, Liao B, Li G (2009) Inhibition of NF-kB expression and allergen-induced airway inflammation in a mouse allergic asthma model by andrographolide. Cell Mol Immunol 6 381-385. 

Nishikubo, K., Murata, Y., Tamaki, S., Sugama, K., Imanaka-Yoshida, K., Yuda, N., Kai, M., Takamura, S., Sebald, W., Adachi, Y. and Yasutomi, Y. (2003). A single administration of interleukin-4 antagonistic mutant DNA inhibits allergic airway inflammation in a mouse model of asthma. GeneTher. 10, 2119-2125. 

MDC levels are significantly elevated in the serum of patients with diseases characterized by the activation of TH2 T cells and this is associated with local expression of MDC at disease sites (Galli et al, 2000). MDC expression has also been found to be elevated in a murine model of asthma (Gonzalo et al, 1999) and in a spontaneous mouse model of atopic dermatitis (Vestergaard et al, 1999). 

Henderson WR Jr, Chi EY, Teo JL, Nguyen C, Kahn M. A Small Molecule Inhibitor of Redox-Regulated NF-(kappa B and Activator Protein-1 Transcription Blocks Allergic Airway Inflammation in a Mouse Asthma Model. J. Immunol. 2002 169 5294-5299. Breinbauer R, Vetter IR, Waldmann H. From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries. Angew. Chem., Int. Ed. Eng. 2002 41 2879-2890. 

Good evidence from animal models indicates that a4 1 (VLA ) is a viable drug target for asthma. Monoclonal antibodies (mAb) against the a4 subunit of VLA-4 have proven efficacious in asthma models in five different species. For example, in a mouse model of asthma, intravenously administered anti-a4 mAb eliminated eosinophilia but did not affect AHR. In contrast, when delivered intranasally, the mAb blocked both airway inflammation and AHR (54). The small-molecule VLA-4 antagonist (2S)-3-(4-Dimethylcarbamoyloxyphenyl)-2- ((4R)-5, 5-dimethyl-3-(l-methyl-lH-pyrazole-4sulfonyl)thiazolidine -... 

Hahn C, Teufel M, Herz U, Renz H, Erh KJ, Wohllehen G, Brocket EB, Duschl A, Sebald W, Grunewald SM. Inhihition of the IL-4/IL-13 receptor system prevents allergic sensitization without affecting established allergy in a mouse model for allergic asthma. J. Allergy Clin. Immunol. 2003 111 1361-1369. 

Cheng G, Arima M, Honda K, Hirata H, Eda F, Yoshida N, Fukushima F, Ishii Y, Fukuda T. Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model. Am. J. Respir. Crit. Care. Med. 2002 166 409 16. 

Henderson WR, Chi EY, Albert RK, Chu SJ, Lamm WJ, Rochon Y, Jonas M, Christie PE, Harlan JM. Blockade of CD49d (alpha4 integrin) on intrapuhnonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. J. Clin. Invest. 1997 100 3083-3092. 

Vanoirbeek JA, Tarkowski M, Vanhooren HM, et al. Validation of a mouse model of chemical-induced asthma using trimellitic anhydride, a respiratory sensitizer and dinitrochlorobenzene, a dermal sensitizer. J Allergy Clin Immunol 2006 117(5) 1090-7. 

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