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Liver x-receptor agonists

M., Burton, C., Sparrow, C.P., Menke, J.G. and Singh, S.B. (2005) Design, synthesis, and structure-activity relationship of podocarpic add amides as liver X receptor agonists for potential treatment of atherosclerosis. Bioorganic at Medicinal Chemistry Letters, 15, 4574—4578. [Pg.337]

NO inhibitors HIF inhibitors Dandrolene-related agents Novel lipoproteins Liver X receptor agonists Nutrigenomics Nutraceuticals Brain metabolic enhancers... [Pg.229]

Fukumoto, H., Deng, A., Irizarry, M.C., Fitzgerald, M.L., Rebeck, G.W. (2002) Induction of the cholesterol transport ABCAl in central nervous system cells by liver X receptor agonists increases secreted AP levels. J. Biol. Chem., 277, 48508-48513. [Pg.353]

J. Fukuchl, J.M. Kokontls, R.A. Hllpakka, C.P. Chuu, S. Liao, Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells, Cancer Res. 64 (2004) 7686-7689. [Pg.263]

Katz A, Udata C, Ott E, Hickey L, Burczynski ME, Burghart P, Vesterqvist O, Meng X (2009) Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants. J Clin Pharmacol 49 643-649... [Pg.299]

Nuclear Receptor Agonists/ Liver X Receptor Agonists... [Pg.436]

The development of liver X receptor agonists has been an area of interest for over a decade, given the critical role of those receptors in cholesterol metabolism, glucose homeostasis, inflammation, innate immunity, and lipogenesis. Potential indications include atherosclerosis, diabetes, inflammation, AD, and cancer [442, 443],... [Pg.436]

Namjoshi DR, Martin G, Donkin J, Wilkinson A, Stukas S, Fan J et al (2013) The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E. PLoS One 8 e53529. doi 10.1371/journal. pone.0053529... [Pg.540]

Seidel, H.M., Haslam, J., Chow, D., Tuntland, T., Spalding, T.A., Brock, A., Bradley, M., Castrillo, A., Tontonoz, P. and Saez, E. (2007) N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRp. Journal of Medicinal Chemistry, 50, 4255-4259. [Pg.22]

Liang, G., Yang, J., Horton, J. D., Hammer, R. E., Goldstein, J. L., and Brown, M. S. Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice... [Pg.41]

Levin N, Bischoff ED, Daige CL, Thomas D, Vu CT, Heyman RA, Tangirala RK, Schulman IG (2005) Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists. Arterioscler Thromb Vase Biol 25 135-142... [Pg.298]

Norata GD, Ongari M, Uboldi P, Pellegatta F, Catapano AL (2005) Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells. Int J Mol Med 16 717-722... [Pg.299]

Nuclear receptor agonists/Liver X Receptor (LXR) agonists 24S -Hydroxycholesterol 27-Hydroxycholesterol GW3965 T0901317... [Pg.391]

Liver X receptors (LXRs) are nuclear receptors involved in the regulation of lipid metabolism and inflammatory responses in the CNS [440], LXR agonists induce the transcriptional activity of LXR target genes, attenuating the imbalance of cholesterol metabolism and overactivation of microglia and astrocytes in inflammation [441],... [Pg.436]

Figure 12.3 Structure-based virtual screening examples for nuclear receptors, (a) Two thyroid hormone receptor antagonists with IC50 values of 20pM (left) and 0.75 pM (right), (b) Liver X receptor (LXR) agonist, EC50 0.21 pM for LXRp. (c) Liver X receptor (LXR) agonist. Figure 12.3 Structure-based virtual screening examples for nuclear receptors, (a) Two thyroid hormone receptor antagonists with IC50 values of 20pM (left) and 0.75 pM (right), (b) Liver X receptor (LXR) agonist, EC50 0.21 pM for LXRp. (c) Liver X receptor (LXR) agonist.
S.-H., Liu, J., Morera, L., Schneider, L., Sakurai, N., Jack, R., and Cheng, J.-F. (2007) Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists. Bioorganic ej Medicinal Chemistry Letters, 17, 3473-3479. [Pg.351]

FIGURE 15.2 Anti-inflammatory effects exerted by liver X receptor (LXR) agonists on vascular endothelial cells (ECs), smooth muscle cells (SMCs) and macrophages. ABC, ATP-binding cassette transporter ICAM-l, intercellular adhesion molecule-1 VCAM-1, vascular cell adhesion molecule-1 IL, interleukin MMP-9, matrix metaUoprotease-9 COX-2, cyclooxygenase-2 MCP-1, monocyte chemotactic protein-1 iNOS, inducible nitric oxide synthase. [Pg.314]

Discovery and structure-activity relationships of substituted tetrahydroisoquinoline as liver X receptor (LXR) agonists... [Pg.202]

See other pages where Liver x-receptor agonists is mentioned: [Pg.337]    [Pg.436]    [Pg.316]    [Pg.337]    [Pg.436]    [Pg.316]    [Pg.186]    [Pg.337]    [Pg.261]    [Pg.241]    [Pg.247]    [Pg.328]    [Pg.1325]    [Pg.620]    [Pg.132]    [Pg.504]    [Pg.91]    [Pg.91]    [Pg.103]    [Pg.391]    [Pg.633]    [Pg.148]    [Pg.326]    [Pg.103]    [Pg.7]    [Pg.803]    [Pg.144]    [Pg.202]    [Pg.426]    [Pg.277]    [Pg.307]    [Pg.207]    [Pg.203]    [Pg.173]   
See also in sourсe #XX -- [ Pg.3 , Pg.371 ]



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