Liver receptor

P. Tontonoz and D. J. Mangelsdorf, Liver Receptor Pathway in Cardiovascular Disease, Mol. Endocrinol., 2003, 17, 985-993. 

Kidney, liver Receptor-mediated endocytosis Sugar, charge... 

Fig. 3. Cross-linking of l25I-labelled human GH to rabbit liver receptors. Labelled GH was incubated with receptors, cross-linked with disuccinimidyl suberate and then subjected to SDS polyacrylamide gel electrophoresis. 1. Total binding 2-4. Displacement with 1 fig unlabelled human GH, bovine GH and ovine prolactin respectively 5. l25I-human GH without receptors. Note the major GH-receptor complex of M, = 80000 (indicating a receptor protein or subunit of Af, 58000) and various other components of larger and smaller M,.

Li Y, et al. Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1. Mol. CeU, 2005 17 491-502. Wang W, et al. The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1. Proc. Natl. Acad. Sci. U.S.A, 2005 102 7505-7510. 

Whitby RJ, et al. Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1. J. Med. Chem. 2006 49 6652-6655. 

B13. Baxter, R. C., Brown, A. S., and Turtle, J. R., Association between serum insulin, serum somatomedin and liver receptors for human growth hormone in streptozotocin diabetes. Horm. Metab. Res. 12, 377-381 (1980). 

Liver receptor homologous protein 1 LRH1 NR5A2 orphan... 

Subfamily 5 steroidogenic factor homology steroidogenic factor-1 (SF1) liver receptor homolog-1 (LRH1)... 

Chen, F., Ma, L., Dawson, P. A., Sinai, C. J., Sehayek, E., Gonzalez, F. J., Breslow, J., Ananthanarayanan, M., and Shneider, B. L. (2003) Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter../. Biol. Chem. 278, 19909-19916. 

Clyne, C. D., Speed, C. J., Zhou, J., and Simpson, E. R. (2002). Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes. J Biol Chem 277, 20591-20597. 

Hadizadeh, S., King, D., Shah, S., and Sewer, M. B. (2007). Sphingosine-l-phosphate regulates the expression of the liver receptor homologue-1. Molecular and Cellular Endocrinology In press, accepted manuscript, available online 5 December 2007, doi 10.1016l j.mce.2007.II.030. 

E 34000 Liver, intestine, macrophage Binds to LDL receptor and probably also to another specific liver receptor... 

Liver receptor homologous protein 1 LRH1 NR5A2 Phospholipids Role in lipid homeostasis, cell-cycle control... 

In adipose tissue, the promoter from exon 1.4 is utilized . The same exon is utilized in bone and skin 303, jjj leiomyoma tissue derived from myometrium . This system is regulated with Spl, a glucocorticoid regulatory element, STAT3, and possibly PPAR - . Pre-adipocytes also involve regulation with liver receptor homolog-1 (LRH-1) 30 . 

The orphan nuclear receptor, liver receptor homolog-1, regulates cholesterolside-chain cleavage cytochrome P450 enzyme in human granulosa cells. J Clin Endocrinol Metab 90 1678-1685... 

Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes. J Biol Chem 277 20591 20597... 

A second affinity chromatographic procedure is based on the interaction of apolipoprotein E with heparin. This technique has been frequently employed, and two applications ought to be mentioned. Weisgraber and Mahley demonstrated the existence of a minor HDL fraction which they found in HDL2 [7]. This subfraction contained, in contrast to the rest of HDL, apolipoprotein E. This lipoprotein may be of special interest for two reasons (a) it binds avidly to liver receptors, and (b) it can be stimulated by cholesterol intake. Mahley speculated that this particle, which he named HDLc, may be involved in reverse cholesterol transport [8]. 

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