Liver adenoma oral contraceptives

Oral contraceptives, estrogens, and benign liver tumors The effects of oral contraceptives on the liver include not only benign liver tumors (focal nodular hyperplasia, hepatic adenoma, and hemangioma) (74) and hepatocellular carcinoma, but also peliosis hepatis (75), sinusoid dilatation (76), and such probably unrelated shorter-term complications as jaundice and gallstones. 

Buhler H, Pirovino M, Akobiantz A, Altorfer J, Weitzel M, Maranta E, Schmid M. Regression of liver cell adenoma. A follow-up study of three consecutive patients after discontinuation of oral contraceptive use. Gastroenterology 1982 82(4) 775-82. 

Benign liver tumors (hepatocellular adenoma and focal nodular hyperplasia) are extremely rare conditions that appear to be related to oral contraceptive use (212). 

Meissner, K. Hemorrhage caused by ruptured liver cell adenoma following long-term oral contraceptives a case report. Hepato-Gastroenterol. 1998 45 224-225... 

Cosme, A., Horcajada, J.R, Vidaur, F., Ojeda, E., Torrado, J., Arenas, J.I. Systemic amyloidosis induced by oral contraceptive-associated hepatocellular adenoma a 13 year follow-up. Liver 1995 15 164—167... 

Tao, L.C. Oral contraceptive-associated liver cell adenoma and hepa-... 

Edmondson, H. A., Reynolds, T. B., Henderson, B., and Benton, B. (1977). Regression of liver cell adenomas associated with oral contraceptives. Ann Intern Med 86, 180-182. 

There is not a widespread association between oral contraceptives and cancer. Combined oral contraceptives may increase the risk of cervical cancer by about twofold, but only in long-term users with human papilloma virus infection. There are reported increases in the incidence of hepatic adenoma and hepatocellular carcinoma in oral contraceptive users (perhaps a doubling in the risk of liver cancer after 4-8 years of use) but these are rare cancers and the absolute increases are small. 

Riberio A, Burgart LJ, Nagorney DM et al (1998) Management of liver adenomatosis results with a conservative surgical approach. Liver Transpl Siug 4 388-398 Rooks JB, Ory HW, Ishak KG, et al (1979) Epidemiology of hepatocellular adenoma the role of oral contraceptive use. JAMA 242 644-648... 

The frequency with which hepatic adenoma occurs during oral contraceptive treatment is not clear. It is probably a rare reaction since the number of cases reported in the literature is so small in relation to the number of women who have been using oral contraceptives. Because of the severity of the reaction, however, a careful watch on the problem must be kept and when an abdominal emergency develops in a woman of childbearing age the possibility of a ruptured liver adenoma must be born in mind. 

Liver cell adenoma and oral contraceptives. Double tumor development. J. Amer. med. Ass., 234, 628. 

Antoniades, K. and Brooks Jr., C. E. (1975) Hemoperitoneum from liver cell adenoma in a patient on oral contraceptives. Surgery, 77, 137. 

Benign liver cell adenoma associated with use of oral contraceptive agents. Am. Surg., 183, 239. 

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