Mass spectrometry nuclear magnetic resonance

Boutin JA, Hennig P, Lambert PH, Bertin S, Petit L, Mahiev JP, Serkiz B, Volland JP, Fauchere JL, Combinatorial peptide libraries Robotic synthesis and analysis by nuclear magnetic resonance, mass spectrometry, tandem mass spectrometry, and high-performance capillary electophoresis techniques, Anal. Biochem., 234 126-141, 1996. 

N. J. C. Bailey, P. D. Stanley, S. T. Hadfield, J. C. Lindon, and J. K. Nicholson, Mass spectrometricahy detected directly coupled high performance liqnid chromato-graphy/nuclear magnetic resonance/mass spectrometry for the identification of... 

D. Bao, V.Thanabal, and W. F. Pool, Determination of tacrine metabolites in microsomal incubate by high-performance liquid chromatography-nuclear magnetic resonance/mass spectrometry with a column trapping system, /. Pharma. Biomed. Anal. 28 (2002), 23-30. 

F. S. Pullen, A. G. Swanson, M. J. Newman, and D. S. Richards, On-line liquid chromatography/nuclear magnetic resonance mass spectrometry—A powerful... 

Pullen, F.S. Swanson, A.G. Newman, M.J. Richards, D.S. Online liquid chromatography/nuclear magnetic resonance/ mass spectrometry—a powerful spectroscopic tool for the analysis of mixtures of pharmaceutical interest. Rapid Com-mun. Mass Spectrom. 1995, 9, 1003-1006. 

The solid catalyst was recovered by filtration on fritted glass and washed with ethyl acetate. The solution was analyzed by gas phase chromatography, and the nature of the final products was confirmed by a complete spectroscopic analysis (infrared, nuclear magnetic resonance, mass spectrometry). 

As irradiation time or monomer concentration increased, the copolymer yield and the NaMA content in the copolymer increased. The structure of the copolymer was identified as having a block form by infrared, nuclear magnetic resonance, mass spectrometry, etc. 

B. Volland, J.P f auchbre, J.L. Combinatorial Peptide Libraries Robotic Synthesis and Analysis by Nuclear Magnetic Resonance, Mass Spectrometry, Tandem Mass Spectrometry, and High-performance Capillary Electrophoresis Techniques, AnflZ. Biochem. 234, 126-141 (1996). 

Computer-Assisted Infrared Raman Spectroscopy Nuclear Magnetic Resonance Mass Spectrometry (MS)... 

Liquid chromatography (LC) has already been described and is an excellent separation technique for compounds that are nonvolatile, thermally unstable and relatively polar in nature. The usual detectors for LC are based on refractive index, conductivity, amperometry, light scattering, UV and fluorescence, all of which have been discussed in Section 3.2. However, sometimes it is desirable to have a more powerful detector attached to an LC instrument and, as such, the following combinations are possible LC-infrared spectrometry, LC-atomic spectrometry, LC-inductively coupled plasma-mass spectrometry, LC-mass spectrometry, LC-UV-mass spectrometry, LC-nuclear magnetic resonance and even LC-nuclear magnetic resonance-mass spectrometry. 

Section I covers the more conventional equipment available for analytical scientists. I have used a unified means of illustrating the composition of instruments over the five chapters in this section. This system describes each piece of equipment in terms of five modules - source, sample, discriminator, detector and output device. I believe this system allows for easily comparing and contrasting of instruments across the various categories, as opposed to other texts where different instrument types are represented by different schematic styles. Chapter 2 in this section describes the spectroscopic techniques of visible and ultraviolet spectrophotometry, near infrared, mid-infrared and Raman spectrometry, fluorescence and phosphorescence, nuclear magnetic resonance, mass spectrometry and, finally, a section on atomic spectrometric techniques. I have used the aspirin molecule as an example all the way through this section so that the spectral data obtained from each... 

JA Boutin, P Hennig, P-H Lambert, et al. Combinatorial peptide libraries robotic synthesis and analysis by nuclear magnetic resonance, mass spectrometry, tandem... 

Section. 1 treats molecular s K ctroscopy in nine chapters that describe absorption, emission, luminescence. infrared, Raman, nuclear magnetic resonance. mass spectrometry, and surface analytical methods. 

If the objective is identification (qualitative analysis), it suffices to compare the spectrum of the analyte with that of a standard, both recorded in the same solvent and at an identical pH. This is not the main application of UV-Vis spectrophotometry as the best results in this context are provided by spectroscopic methods considered more effective for the study of the molecular structure of organic compounds (infrared, nuclear magnetic resonance, mass spectrometry, and X-ray diffraction). However, UV-Vis spectrophotometry is a source of relevant supplementary information that helps in the elucidation of molecular structures of drugs, impurities, metabolites, intermediate compounds of degradation, etc. 

Scarfe, G.B. Wilson, I.D. Spraul, M. Hofmann, M. Braumann, U. Lindon, J.C. Nicholson, J.K. Apphcation of directly coupled high-performance hquid chromatography-nuclear magnetic resonance-mass spectrometry to the... 

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