Liquid chromatography bioanalytical application

T. A. G. Noctor, Bioanalytical applications of enantioselective high-performance liquid cliromatography in A Practical Approach to Chiral Separations by Liquid Chromatography, Subramanian G (Ed.), VCH, Weinheim, Ch. 12, pp. 357-396 (1994). [Pg.293]

Mei H, Hseih Y, Nardo C, Xu X, Wang S, et al. 2003. Investigation of matrix effects in bioanalytical high performance liquid chromatography/tandem, mass spectrometrometic assay application to drug discovery. Rapid Commun Mass Spectrom 17 97-103. [Pg.39]

C. E. Bioanalytical applications of fast chromatography to high-throughput liquid chromatography/ tandem mass spectrometric quantitation. Rapid Commun... [Pg.424]

Romanyshyn, L., Tiller, P. R., and Hop, C. E. (2000). Bioanalytical applications of fast chromatography to high-throughput liquid chromatography/tandem mass spectrometric quantitation. Rapid Commun. Mass Spectrom. 14 1662-1668. [Pg.79]

Shoup, R. E. Bruntlett, C. S. Bratin, K. Kissinger, P. T. "Principles and Applications of Liquid Chromatography with Electrochemical Detection" Bioanalytical Systems, Inc. [Pg.88]

Mei, H. Hsieh, Y Nardo, C. Xu, X. Wang, S. Ng, K. Korfmacher, W.A. Investigation of Matrix Effects in Bioanalytical High-Performance Liquid Chromatography/Tandem Mass Spectrometric Assays Application to Drug Discovery, Rapid Commun. Mass Spectrom. 17, 97-103 (2003). [Pg.357]

High-pressure liquid chromatography (HPLC) formats that use reverse-phase analytical columns dominate the bioanalytical field. Isocratic elution formats are used for traditional LC-MS/MS bioanalysis, since these separations do not require additional time for column reequilibration. However, gradient elution is a more effective approach for cassette analysis in highthrough-put screening methods for discovery applications because of its versatility for the separation of compounds that have a wide variety of lipophilicity. [Pg.473]

The focus of this chapter is on quality assurance and quality control issues facing clinical laboratories, with emphasis on chromatographic analysis. Chromatography is a versatile analytical technique with diverse applications including gas chromatography (GC), liquid chromatography (LC), GC or LC coupled with mass spectrometry (MS) and other qualitative and quantitative bioanalytical methods. [Pg.1]

Mass spectrometry (MS) is one of the most powerful detection techniques used in liquid-phase analyses,1 mainly due to the ease of interfacing with separation techniques such as capillary electrophoresis (CE)2,3 and high-performance liquid chromatography (HPLC).4 Due to its sensitivity and applicability to a wide variety of chemical and biochemical species, MS is also used for the analysis of (bio)chemical molecules processed in microfluidics devices.5,6 Electrospray ionization (ESI)7 10 is often used to transfer samples from microfluidics chips to a mass spectrometer, involving analyte ionization directly from solutions and operating at flow rates typically used in microfluidics devices.11 Due to its effectiveness, the use of chip-MS coupling has rapidly spread in many research areas with bioanalytical applications,12 such as the... [Pg.201]

SucKOW, R. F., and Cooper, T. B., 1980, The electrochemical detection of imipramine, desipramine, and their 2-hydroxylated metabolites in plasma using reversed-phase paired-ion liquid chromatography. First International Symposium on Neurochemical and Clinical Applications of LCEC, Indianapolis, Abstract No. 8, Bioanalytical Systems, West Lafayette, Indiana. [Pg.73]

Oliveira, H.M., Segundo, M.A., Lima, J.L.F.C., Miro, M., and Cerda, V., 2010. Exploiting automatic on-line renewable molecularly imprinted solid-phase extraction in lab-on-valve format as front end to liquid chromatography application to the determination of riboflavin in foodstuffs. Analytical and Bioanalytical Chemistry. 397 77-86. [Pg.316]