Bioanalytical Systems

Another dynamic measurement is the LCEC technique which can be thought of, simpHsticaHy, as EIA using a chromatographic column positioned between the sample injection port and the detector. Bioanalytical systems (BAS) of West Lafayette, Indiana, specializes in instmmentation for LCEC. Their catalogs come with extensive bibhographies covering a variety of appHcations. 

Figure 6,16 Cyclic voltammograms as a function of scan rate. This figure comprises traces simulated by the DigiSim program for a reversible one-electron couple, with the fastest scan rate being shown outermost. Reprinted with permission from Current Separations, Vol. 15, pp. 25-30, copyright Bioanalytical Systems, Inc., 1996.

The DigiSim simulation package was compiled by Manfred Rudolph and Stephen Feldberg, in collaboration with Bioanalytical Systems, Inc. (BAS). 

The Current Separations Series (produced free of charge by Bioanalytical Systems, Inc.) is an excellent source of detailed and reliable information. 

Bioanalytical Systems, Inc., 2701 Kent Avenue, West Lafayette, IN 47906-1382, USA or http //www.current separations, com (where some articles can be downloaded as. pdf documents). 

I also wish to thank Dr Lou Coury and Dr Adrian Bott of Bioanalytical Systems, Inc. for their enthusiasm, and permission to reproduce Figures 6.16, 6.18, 6.19, 10.1 and 10.3.1 gladly thank Dr Manfred Rudolph for his description of the DigiSim program. Dr Mike Dawson of E G G for his help concerning the Condecon program, and Dr Keith Dawes of Windsor Scientific for his help, and the permission to reproduce Figure 10.2. 

Peter T. Kissinger Purdue University and Bioanalytical Systems, Inc., West Lafayette, Indiana... 

Carl R. Preddy Purdue University, West Lafayette, Indiana Ronald E. Shoup Bioanalytical Systems, Inc., West Lafayette, Indiana William R. Heineman University of Cincinnati, Cincinnati, Ohio... 

In early 1983, Bioanalytical Systems introduced a new class of integrated processor-driven instrumentation based on a concept first developed by Faulkner and his co-workers [1] at the University of Illinois. This unit (Figs. 6.22 and 6.23) has evolved over the years and now includes a repertoire of some 35 electrochemical techniques, including the most popular large-amplitude (Chap. 3) and small-amplitude (Chap. 5) controlled-potential methods. The unit also is capable of determining electrocapillary curves and can automatically measure and compensate for solution resistance (R in Fig. 6.5). Thus in a single instrument it is possible to utilize virtually all of the diagnostic criteria introduced in Chapters 3 and 5 and also to explore quickly which technique is optimum for... 

At this writing it is possible to link digital instrumentation with notebook computers and even achieve portability. Developments have been so rapid in this area that it is difficult to imagine what will come next. General-purpose processor-based electroanalytical instruments are now available from Amel, Bioanalytical Systems, Cypress Systems, EcoChemie, Metrohm, Tacussel, and Princeton Applied Research. 

Mercury is the electrode material of choice for many electrochemical reductions and some unique oxidations (see Chap. 14). We have explored the use of both small mercury pools and amalgamated gold disks in thin-layer amperometry. Other workers have used pools in a capillary tube [7] and amalgamated platinum wire [8]. In 1979, Princeton Applied Research introduced a unique approach based on their model 303 static mercury drop electrode (see Sec. II.F). Our laboratories and MacCrehan et al. [9] have focused on the use of amalgamated gold disks. This approach results in an inexpensive, easily prepared, and mechanically rigid electrode that can be used in conventional thin-layer cells (Sec. II.C) of the type manufactured by Bioanalytical Systems. 

Figure 27.5 Commercial thin-layer LCEC detectors. [Courtesy of Bioanalytical Systems, Inc.]...

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