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Cassette analysis

Cassette analysis (performed by user) Mix samples, injected to same LC-MS or infused to MS... [Pg.139]

Sadagopan, N. Pabst, B. Cohen, L. Evaluation of online extraction/mass spectrometry for in vivo cassette analysis. J Chromatogr B Anal Technol Biomed Life Sei 2005, 820, 59-67. [Pg.424]

Cai, Z., Han, C., Harrelson, S., Fung, E., and Sinhababu, A. K. (2001). High-throughput analysis in drug discovery Application of liquid chromatography/ion-trap mass spectrometry for simultaneous cassette analysis of alpha-la antagonists and their metabolites in mouse plasma. Rapid Commun. Mass Spectrom. 15 546-550. [Pg.65]

Smalley, J., Kadiyala, P., Xin, B., Balimane, P., and Olah, T. (2006). Development of an online extraction turbulent-flow chromatography tandem mass spectrometry method for cassette analysis of Caco-2 cell based bi-directional assay samples. J. Chromatogr. B Ana. Technol. Biomed. Life Sci. 830 270-277. [Pg.339]

Halladay JS, Wong S, Jaffer SM, Sinhababu AK, Khojasteh-Bakht SC. Metabolic stability screen for drug discovery using cassette analysis and column switching. Drug Metabol. Lett. 2007 1 67-72. [Pg.1975]

Cai Z, Sinhababu AK, Harrelson S. Simultaneous quantitative cassette analysis of drugs and detection of their metabolites by high performance liquid chromatography/ion trap mass spectrometry. Rapid Commun. Mass Spect. 2000 14 1637-1643. [Pg.1975]

The throughput in organ perfusion studies has increased dramatically with the use of technologies for fast LC-MS separation, dual- or multiple-column LC-MS, turbulent-flow LC-MS, and cassette analysis [13-17]. [Pg.472]

High-pressure liquid chromatography (HPLC) formats that use reverse-phase analytical columns dominate the bioanalytical field. Isocratic elution formats are used for traditional LC-MS/MS bioanalysis, since these separations do not require additional time for column reequilibration. However, gradient elution is a more effective approach for cassette analysis in highthrough-put screening methods for discovery applications because of its versatility for the separation of compounds that have a wide variety of lipophilicity. [Pg.473]

Cai, Z. Sinhababu, A.K. Harrelson, S. "Simultaneous Quantitative Cassette Analysis of Drugs and Detection of Their Metabolites by High Performance Liquid Chromatography/Ion Trap Mass Spectrometry, Rapid Commun. Mass Spectrom. 14,1637-1643 (2001). [Pg.475]

Figure 21.7. Cassette analysis of six CYP probe substrates (CYP1A2, CYP2C8, CYP2C9, C YP2C19, CYP2D6, C YP3A4) separated on a5- rmphenylcoluiim (1 mm X 50 mm) operated at 700 pL/min. The samples were detected in the MRM mode on an API4000 triple quadrupole mass spectrometer. Figure 21.7. Cassette analysis of six CYP probe substrates (CYP1A2, CYP2C8, CYP2C9, C YP2C19, CYP2D6, C YP3A4) separated on a5- rmphenylcoluiim (1 mm X 50 mm) operated at 700 pL/min. The samples were detected in the MRM mode on an API4000 triple quadrupole mass spectrometer.
Figure 21.8. Standard probe inhibitiors for CYP1A2, CYP 2C8, CYP 2C9, CYP 2C19, CYP 2D6, and CYP 3A4 were incubated at eight inhibitor concentrations and analyzed by LC/MS/MS using cassette analysis, as described in the previous figure. Experimentally derived IC50 values for each of the probe inhibitors compared favorably with Uteratuie values. Figure 21.8. Standard probe inhibitiors for CYP1A2, CYP 2C8, CYP 2C9, CYP 2C19, CYP 2D6, and CYP 3A4 were incubated at eight inhibitor concentrations and analyzed by LC/MS/MS using cassette analysis, as described in the previous figure. Experimentally derived IC50 values for each of the probe inhibitors compared favorably with Uteratuie values.
See other pages where Cassette analysis is mentioned: [Pg.194]    [Pg.436]    [Pg.437]    [Pg.472]    [Pg.147]    [Pg.178]    [Pg.129]    [Pg.816]   
See also in sourсe #XX -- [ Pg.129 ]



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