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Lipids ageing

Those authors also demonstrated that neither sexual stage nor age of plant had any effect on the qualitative composition of the lipid fractions. They did comment, however, on the possibility that the secondary chemical output of plants at these different sites might reflect local environmental conditions, especially considering that the distance between the sites at Castelluccio and Brucoli is only a few kilometers. They pointed to the work of Howard et al. (1980), who had demonstrated such effects on the chemical content of two species of Laurencia in California over... [Pg.241]

Bonithon-Kopp, C. et al.. Combined effects of lipid peroxidation and antioxidant status on carotid atherosclerosis in a population aged 59-71 years The EVA (Etude sur le Vieillisement Arteriel) study. Am. J. Clin. Nutr, 65, 121, 1997. [Pg.142]

PLC of lipids is discussed in Chapter 12. Lipids play a vital role in virtually all aspects of human and animal life. Many smdies of food quality, human health, metabolic and ageing processes, pheromone activity in animals, etc., benefit greatly from the use of PLC for the separation and isolation of lipids. [Pg.9]

During the ageing process, the increased levels of an age pigment , lipofiiscin, which results from lipid peroxidation, is convincing evidence of accumulative ffee-tadical... [Pg.79]

Andorn, A.C., Britton, R.S. and Bacon, B.R. (1990). Evidence that lipid peroxidation and total iron are increased in Alzheimer s brain. Neurobiol. Aging 11, 316-320. [Pg.80]

We have already stressed the potential importance of lipid-rich membranes in the skin as potential targets for ROS-induced damage and ageing of human skin is morphologically identical to changes found by peroxidative processes (Serri et al., 1977). The involvement of AA metabolites in skin disease, and in particular psoriasis, has been the subject of much recent interest. Studies have included topical and intradermal administrations of AA metabolites, and assay of such products in clinical specimens. Results show that concentration of AA, 12-hydroxy-eicosatetraenoic acid (12-HETE), PG and leu-kotrienes are increased in psoriatic lesions (Hammarstrom etal., 1975 Camp etal., 1983 Brain etal., 1984 Duell et al., 1988) and also that full-thickness epidermis from normal and diseased skin has the enzymatic capacity to convert AA to some of the same metabolites (Hammarstrom etal., 1975, 1979 Camp etal., 1983 Brain etal., 1984 Ziboh et al., 1984 DueU et al., 1988). The biological effect of both 12-HETE and leukotrienes was confirmed by both topical application and intradermal injection, which caused epidermal inflammation and... [Pg.118]

Primary and secondary products, and end-products of lipid peroxidation have all been shown to accumulate in senile cataracts (Babizhayev, 1989b Simonelli et al., 1989). Accumulation of these compounds in the lenticular epithelial membranes is a possible cause of damage preceding cataract formation. In senile cataracts there is also extensive oxidation of protein methionine and cysteine in both the membrane and cytosol components (Garner and Spector, 1980), while in aged normal lenses a lesser extent of oxidation was confined to the membrane. The authors therefore suggested that oxidation of membrane components was a precataract state. [Pg.131]

Hiramatsu, M., Edamatsu, R., Ohyama, H. and Mori, A. (1992). Effect of Japanese herbal medicine, sho-saiko-to-go-keishi-kashakuyaku-to (TJ-960) on aging. In Lipid-soluble Antioxidants Biochemistry and Clinical Applications (eds. A.S.H. Ong and L. Packer) pp. 535-552. Birkhauser Verlag, Basel. [Pg.258]

Elevated cholesterol levels in transplant patients are due to a culmination of factors such as age, genetic disposition, renal dysfunction, DM, proteinuria, body weight, and immunosuppressive therapy. Many of the immunosuppressive agents can produce elevations in serum lipid levels. [Pg.848]

As has been pointed out earlier in this chapter, the dietary consumption and historical medicinal use of carotenoids has been well documented. In the modern age, in addition to crocin, 3.7, and norbixin, 3.8, several carotenoids have become extremely important commercially. These include, in particular, astaxanthin, 3.6 (fish, swine, and poultry feed, and recently human nutritional supplements) lutein, 3.4, and zeaxanthin, 3.3 (animal feed and poultry egg production, human nutritional supplements) and lycopene, 3.2 (human nutritional supplements). The inherent lipophilicity of these compounds has limited their potential applications as hydrophilic additives without significant formulation efforts in the diet, the lipid content of the meal increases the absorption of these nutrients, however, parenteral administration to potentially effective therapeutic levels requires separate formulation that is sometimes ineffective or toxic (Lockwood et al. 2003). [Pg.51]

Moreover, efficient rhodopsin regeneration may precede enzymatic reduction of all-fran.v-retinal to all-trans-retinol in the aged retina (Figure 15.2c) (Schadel et al., 2003). Upon rhodopsin regeneration, all-trans-retinal is released from the exit site of the protein into the lipid membrane (Figure 15.2c) (Schadel et al., 2003). From here the removal of all-tnms-retinal to the outer leaflet of the disc membrane is dependent on activity of ATP-binding cassette trasporter A4 (ABCA4) present in the rim of photoreceptor disc, known also as ABCR protein. [Pg.317]

Li, CM, Presley, B, Zhang, XM, Dashti, N, Chung, BH, Medeiros, NE, Guidry, C, and Curcio, CA, 2005. Retina expresses microsomal triglyceride transfer protein Implications for age-related maculopathy. J Lipid Res 46, 628-640. [Pg.346]


See other pages where Lipids ageing is mentioned: [Pg.249]    [Pg.11]    [Pg.366]    [Pg.196]    [Pg.249]    [Pg.11]    [Pg.366]    [Pg.196]    [Pg.300]    [Pg.123]    [Pg.526]    [Pg.673]    [Pg.598]    [Pg.198]    [Pg.15]    [Pg.154]    [Pg.118]    [Pg.144]    [Pg.29]    [Pg.302]    [Pg.135]    [Pg.137]    [Pg.407]    [Pg.114]    [Pg.184]    [Pg.185]    [Pg.213]    [Pg.176]    [Pg.180]    [Pg.181]    [Pg.1535]    [Pg.6]    [Pg.258]    [Pg.318]    [Pg.320]    [Pg.368]    [Pg.736]    [Pg.12]    [Pg.317]    [Pg.329]    [Pg.117]    [Pg.267]    [Pg.122]   
See also in sourсe #XX -- [ Pg.101 , Pg.102 ]




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