Lilly

Fluoxetine hydrochloride (Prozac) is a widely prescribed antidepressant drug introduced by Eh Lilly Co in 1986 It differs from Compound A in having an —NHCH3 group in place of —N(CH3)2 What IS the structure of Prozac" ... 

Recovery nd Purifica.tion. The production of EH Lilly s human insulin requires 31 principal processing steps of which 27 are associated with product recovery and purification (13). The production process for human insulin, based on a fermentation which yields proinsulin, provides an instmctive case study on the range of unit operations which must be considered in the recovery and purification of a recombinant product from a bacterial fermentation. Whereas the exact sequence has not been pubUshed, the principle steps in the purification scheme are outlined in Figure la. 

U.S.A., in lactating dairy cattie to increase milk production. EH Lilly and Company, The Upjohn Company, and American Cyanamid Company also have interests in the commercial appHcation of recombinant bovine GH. Recombinant porcine GH [9061-23-8] preparations from several companies, eg. The Upjohn Company, Smith Kline Beecham Animal Health, Pitman-Moore, Inc., Monsanto Company, and American Cyanamid Company, are being evaluated for commercial use. Recombinant human GH for clinical use is marketed under such names as Protropin (Genentech), Umatrope (EH Lilly), Genotropin (Sumitomo), and Somatonorm (Kabi-Vitmm) by a variety of pharmaceutical companies. A listing of additional suppHers is available (2). 

Gerald W. Becker Warren C. MacKellar Ralph M. Riggin Victor J. Wroblewski Lilly Research Laboratories... 

H o ffrnan- LaRo che Smith Kline Beech am Winthrop EH Lilly Du Pont... 

A35512 complex Streptomyces candidus NRRL 8156 1976 Lilly 34-36... 

A51568A (A/-demethyl-vancomycin), B Nocardia orientalis N RRL 15232 1982 Lilly 39,40... 

A41030 complex Streptomyces virginiae NRRL 15156 1982 Lilly 41-43... 

Only three dalbaheptides are commercialized vancomycin (39) and teicoplanin (18—22) for human health, and avoparcin (63—65) for animal usage. Vancomycin, the main trademark of which is EH Lilly s Vancocin had 1990 sales around 160 million. Total annual production is in the vicinity of 8 t. Teicoplanin, trademarked Targocid, had 1990 sales of 35 million corresponding to 200 kg. Teicoplanin is commercialized in Europe, Hong Kong, Korea, and the Middle East. It is at the late developmental clinical phase in North America and Japan. Avoparcin is used as a growth promoting feed additive (see... 

Reactions. Thiosahcyhc acids reacts with ethyhnercuric chloride in alcohol and in the presence of sodium hydroxide to yield sodium ethyhnercurithiosahcylate [54-64-8] (thimerosal Merthiolate, Eh Lilly and Company) (63) (eq. 12). 

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