Eli Lilly and

Biopharmaceutical Product Development, Eli Lilly and Company, Indianapolis, Indiana 4618S... 

The TSK-GEL column is a trademark of Tosoh Haas Co. Ltd and the Waters Insulin HMWP column is a trademark of Waters Corporation. The author thanks the book s editor Chi-san Wu, the assigned peer reviewer, and the Eli Lilly and Company reviwers John Towns, Ralph Riggin, and James Kelley for their assistance, time, and professional comments. 

Lipoic acid (6,8-dithiooctanoic acid) was isolated and characterized in 1951 in studies that showed that it was required for the growth of certain bacteria and protozoa. This accomplishment was one of the most impressive feats of isolation in the early history of biochemistry. Eli Lilly and Co., in cooperation with Lester J. Reed at the University of Texas and I. C. Gunsalus at the... 

Dr. Dawn A. Brooks Lilly Research Laboratories Eli Lilly and Company Lilly Corporate Center Indianapolis, IN 46285... 

British Patent 982,252 February 3,1965 assigned to Eli Lilly and Company... 

This narrative was first presented at Don Boyd s third annual Central Indiana Computational Chemistry Christmas Luncheon (CICCCL-3) on December 18,1997. Although it is specihc for Eli Lilly and Company, the progress and problems that transpired there were probably not too different from developments at other large, forward-looking, research-based pharmaceutical companies. 

I began work at Eli Lilly and Company in March 1942 as a laboratory aide in the analytical department. At that time, there was very little sophisticated instrnmentation in the laboratory. The most complex calculations were carried ont nsing a slide rnle. After military service in World War II and an edncational leave of absence to complete my nndergraduate studies in chemistry at Indiana University, I retnrned to the Lilly analytical group in 1947. Slide rnles were still much in evidence bnt were soon augmented with mechanical calcnlators— usually Monroe or Friden models. 

We are grateful to Dr. Sean Ekins for the opportunity to participate in this book and for his painstaking editing. We thank our many colleagues over the years for what they taught us or tried to teach us. Some of the historical events reviewed here occurred during the period of our respective tenures as members of the staff at the Lilly Research Laboratories of Eli Lilly and Company. We... 

Several companies, for example, Eli Lilly and Company, have said that their research will be made public so people may view the work and come to their own judgments about the efficacy of a drug. And, of course, scientihc research is designed from the start so that results can be shared with other scientists and replicated. 

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