Lillie number

Jiisten [60] took the quantity P/(Vj tp) Zp P/Vj for the correlation of his results which means that in larger reactors less stress takes place at the same power input P/Vj. The assumption that the number of circulations through the impeller zone Zp is decisive for the load of organisms was put forward by Smith, Lilly, Fox [74]. This parameter cannot be important since the circulation frequency l/tp Zp is normally small in comparison to the frequency of turbulent... 

It is a pleasure to acknowledge the skillful and dedicated efforts of our co-workers whose names are to be found among the references and whose achievements have provided the basis of this review. We are also grateful to N.A.T.O. for the provision of Research Grant Number 1559 which has enabled us to collaborate in the production of this article. Our work has been supported by the National Institutes of Health, the National Science Foundation, the Petroleum Research Fund, the Guggenheim Foundation, the Sloan Foundation, Research Corporation, Western Fher Company, Eli Lilly Company, and University of Puerto Rico (WA), and by the Science Research Council (AJB). 

Food stored in a proper way and in proper conditions is not a vehicle of C. botulinum. Unlike non-proteolytic strains, proteolytic strains will not grow in refrigeration temperatures. The number of spores in meat and poultry is rather low, much higher numbers are observed in fish. If stored at 3 to 5°C, vacuum-packed, not very sour meat products usually remain safe for consumers up to 21 days. Botulin toxin was not detected in raw rockfish fillets or red snapper homogenates after being stored for 21 days at 4°C. None of 1074 samples of commercially packed fresh fish stored for 12 days at 12°C contained botulin toxin (Lilly and Kautter, 1990). 

Studies of conditions for the growth of callus tissue of C. roseus were first reported in 1962 (114) by Babcock and Carew, and analytical work commenced when Carew and co-workers (115) demonstrated that in the presence of 0.5 mg/liter kinetin callus tissue grew rapidly and probably produced vindoline (3), as well as a number of other alkaloids. At the same time, a group at Eli Lilly (116) reported an analysis of the alkaloids of crown gall cultures which had been maintained by Hildebrandt s group... 

All three ADHD-approved chemical entities have at least one chiral center, a feature that has led to a number of interesting syntheses of these compounds over the years. Amphetamine (1) and methylphenidate (2) were discovered before the modern era of asymmetric and enantioselective synthesis, and are sold as racemic, single-enantiomer, and enantio-enriched formulations. Atomoxetine (3), hrst presented in a 1977 Eli Lilly patent, was developed as a single-enantiomer drug (Molloy and Schmiegel, 1977). 

Tobramycin sulphate (Nebcin , lot number 1CE30C) was donated by Eli Lilly Co., Indianapolis,... 

If the development work is planned with the goal of passing the PAI and the work complies with CGMP quality principles, there should be only minimal preparations needed for the FDA in the weeks and months just prior to the inspection itself. A number of different methodologies have been developed to help with the short-term preparation efforts. Justice and co-workers at Eli Lilly and Company have described a 10-step process to help guide these preparation efforts [4], These steps can be found inTable 1. 

Dinitroaniline herbicides. Trifluralin (Treflan ), a 4-trifluoromethyl substituted 2,6-dinitroaniline derivative, was the first main fluorine-containing herbicide to be marketed, with 18,000 tons sold in 1982 in the United States alone [16]. Trifluralin, which was introduced in 1960 by Eli Lilly, is a pre-emergence herbicide used in soybean for the control of a variety of grass and broadleaf weeds [17]. It is prepared from the nitration of 4-chlorobenzotrifluoride, followed by nucleophilic displacement of chlorine with di-n-propyl amine (Fig. 3). Following the success of trifluralin, a number of related A/,A/-dialkyl 4-trifluoromethyl 2,6-dinitroaniline herbicides were later introduced [18]. 

The authors are grateful to a number of colleagues at Eli Lilly and Company, including Drs Bernard Olsen and Steven Maple for their encouragement and general discussion, Dr Jack Zheng for extensive discussion on the Excipient Library concept and approach, Ms Li Liu... 

Trifluralin is a dinitroaniline and was introduced by Eli Lilly in 1963 (Fig. 4). It was the first of a number of similar dinitroanilines. It is widely used in cotton and soybeans and is labeled for use on more than 50 crops. It is usually incorporated into the soil prior to planting the crop. 

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