Lilly Pharmaceutical

Researchers from Eli Lilly pharmaceuticals, (a company founded in 1876 by Colonel Eli Lilly veteran of the US Civil War), undertook further intensive phytochemical studies and characterized 60 alkaloids, of which a group of 20 binary indole alkaloids—including vincristine and vinblastine. Vinblastine sulphate (Velbe ) inhibits the polymerization of tubulin and is used to treat generalized Hodgkin s disease and chorionepithelioma, whereas vincristine sulphate (Oncovin ) is used to treat leukemia in children. 

Asked to comment on the impact of the upcoming patent expiration on Ceclor sales, Lilly Pharmaceutical President Gene Step said the relevant questions should be what will be Lilly s overall position in the oral antibiotic market and what is the likelihood of generic versions of cefaclor reaching the market. 

Just as hydrogen bonds are critical in the pairing of nucleotides, they also play a major role in how one of the world s most powerful antibiotics kills bacteria. That antibiotic is vancomycin, a compound first isolated in 1956 by scientists at the Eli Lilly pharmaceutical company from the fermentation broth of a microbe found in the jungles of Borneo. Its name was derived from the verb to vanquish, because it could kill every strain of gram-positive bacteria thrown at it, including the deadly strain known as MRSA (for methicillin-resistant Staphylococcus aureus), one of the so-called flesh-eating bacteria. 

U.S.A., in lactating dairy cattie to increase milk production. EH Lilly and Company, The Upjohn Company, and American Cyanamid Company also have interests in the commercial appHcation of recombinant bovine GH. Recombinant porcine GH [9061-23-8] preparations from several companies, eg. The Upjohn Company, Smith Kline Beecham Animal Health, Pitman-Moore, Inc., Monsanto Company, and American Cyanamid Company, are being evaluated for commercial use. Recombinant human GH for clinical use is marketed under such names as Protropin (Genentech), Umatrope (EH Lilly), Genotropin (Sumitomo), and Somatonorm (Kabi-Vitmm) by a variety of pharmaceutical companies. A listing of additional suppHers is available (2). 

The primary manufacturers are Hoffmaim-LaRoche, Inc., Pfizer, Inc., Agri-Bio Corp. (a division of A. H. Robins), Elanco Products Co. (a division of Eh Lilly and Co.), Hoechst-Roussel Agri Vet Co., American Cyanamid Co., and Kaken Pharmaceutical Co. 

This narrative was first presented at Don Boyd s third annual Central Indiana Computational Chemistry Christmas Luncheon (CICCCL-3) on December 18,1997. Although it is specihc for Eli Lilly and Company, the progress and problems that transpired there were probably not too different from developments at other large, forward-looking, research-based pharmaceutical companies. 

A study of physician attitudes toward capsules and other pharmaceutical product forms. Elanco Products Co., Div. Eli Lilly Co., Indianapolis, IN, 1971, El-0004. 

The medical success of these drugs gave new emphasis to the pharmaceutical industry, which was boosted further by the commencement of industrial-scale penicillin manufacture in the early 1940s. Around this time, many of the current leading pharmaceutical companies (or their forerunners) were founded. Examples include Ciba Geigy, Eli Lilly, Wellcome, Glaxo and Roche. Over the next two to three decades, these companies developed drugs such as tetracyclines, corticosteroids, oral contraceptives, antidepressants and many more. Most of these pharmaceutical substances are manufactured by direct chemical synthesis. 

Criticism of the proposed institute also came from another quarter, namely from the ranks of organized pharmacy. Already in December of 1918, Edward Kremers of the University of Wisconsin School of Pharmacy, one of the nation s leading pharmaceutical educators and a researcher in plant chemistry, wrote to Frank Eldred of Eli Lilly and Company about the institute for drug research. Kremers complained "But why should American pharmaceutical manufacturers support an institution fostered by the American Chemical Society when pharmaceutical institutions are in the greatest need of all the financial support in sight. I trust that our pharmaceutical manufacturers will prove true to their own calling first" (44). 

Intellectual property rights (IPRs) are an important asset for the pharmaceutical industry. Most successful companies have suites of patents to protect their IPRs. The effect of IPR protection is amply demonstrated by the Prozac case. Fluoxetine (Prozac, Eli Lilly) was a blockbuster drug for many years. During... 

Another screening strategy using the same type of columns but with normal-phase gradient elution has been proposed by the pharmaceutical group Lilly.In this strategy, each compound is screened on four columns, i.e., Chiralcel OD-H, Chiralpak AD, Chiralpak AS and Chiralcel OJ. An n-hexane/2-propanol and an n-hexane/EtOH gradient elution system are... 

The present review illustrates that UV-vis based process analytical technology is widely discussed, but published examples are still scarce. The pharmaceutical industry, driven by the FDA s PAT initiative, can be seen as a forerunner. This is reflected by the observation that many references in this chapter are (co-) authored by representatives from pharmaceutical companies like Glaxo Wellcome and GlaxoSmithKline, ° " ° Astra Zeneca, Novartis and Eli Lilly. ... 

Elan Pharmaceutical Research Corporation Eli Lilly and Company Glaxo Wellcome, Inc. 

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