Smith Kline Beecham

U.S.A., in lactating dairy cattie to increase milk production. EH Lilly and Company, The Upjohn Company, and American Cyanamid Company also have interests in the commercial appHcation of recombinant bovine GH. Recombinant porcine GH [9061-23-8] preparations from several companies, eg. The Upjohn Company, Smith Kline Beecham Animal Health, Pitman-Moore, Inc., Monsanto Company, and American Cyanamid Company, are being evaluated for commercial use. Recombinant human GH for clinical use is marketed under such names as Protropin (Genentech), Umatrope (EH Lilly), Genotropin (Sumitomo), and Somatonorm (Kabi-Vitmm) by a variety of pharmaceutical companies. A listing of additional suppHers is available (2). 

Smith Kline Beecham, formerly Smith Kline Beckman. 

M1P18879 R. A. Daines and W. D. Kingsbury (Smith, Kline, Beecham Corp.), PCT... 

Pertussis toxin (PT) (Glaxo Smith Kline Beecham, Rixensart, Belgium). 

Other immobilized enzyme product successes (where annual production of immobilized enzymes has surpassed 1 ton/year) comprise Aminoacylase (Amano), hydantoinase (Smith Kline Beecham), lactase (Valio), lipase (Novo Nordisk), penicillin G acylase (Gist-brocades, Smith Kline Beecham, Rohm) and penicillin V acylase (Novo Nordisk/Gist-brocades) (Poulsen, 1984). 

Smith Kline Beecham broke off talks with American Home Products. 

Schering-Plough, AKZO (Organon), Hofmann LaRoche (Syntex), Merck, American Home Products (Wyeth), etc. Penicillins/cephalosporins Eh Lilly, Glaxo-Smith-Kline (Beecham),... 

The treatment of infectious diseases relies on antibiotics such as the penicillins to prevent bacteria from multiplying. One of the most successful of these is Smith Kline Beecham s amoxycillin. The four-membered ring at the heart of the molecule is the p-lactam . 

The natural penicillins, primarily G and V, have a relatively narrow spectrum. They act mostly on gram-positive organisms. The fact that proper selection of precursors could lead to new variations in the penicillin side chain offered the first source of synthetic penicillins. Penicillin V, derived from a phenoxy-acetic acid precursor, attracted clinical use because of its greater acid tolerance, which made it more useful in oral administration. Also, the widespread use of penicillin eventually led to a clinical problem of penicillin-resistant staphylococci and streptococci. Resistance for the most part involved the penicillin-destroying enzyme, penicillinase, which attacked the beta-lactam structure of the 6-aminopenicillanic acid nucleus (6-APA). Semisynthetic penicillins such as ampicillin and carbenicillin have a broader spectrum. Some, such as methicillin, orafi-cillin, and oxacillin, are resistant to penicillinase. In 1984, Beecham introduced Augmentin, which was the first combination formulation of a penicillin (amoxicillin) and a penicillinase inhibitor (clavulanic acid). Worldwide production of semisynthetic penicillins is currently around 10,000 tons/year, the major producers are Smith Kline Beecham, DSM, Pfizer, and Toyo Jozo. 

Targeting the treatment of AIDS, a group at Smith Kline Beecham established a screening method to identify bioactive sub.stances which inhibit the HIV binding to human CD4" receptor. 

Recombivax (Merck), Engerix B (Smith-Kline Beecham) and Bimmugen (Kaketsuken) are the commercial hepatitis B virus (HBV) vaccines. This is the first recombinant human vaccine to receive approval world... 

Amino acids Havrix (Smith Kline Beecham)... 

Smith Kline Beecham Pharmaceuticals Brockham Park, Surrey United Kingdom... 

Methionine is included in some proprietary paracetamol products (Pameton Smith Kline Beecham), since it counteracts some serious side-effects that are encountered with paracetamol overdosing through helping to restore glutathione levels that are the body s natural defence against products of oxidised paracetamol. However, the recommended antidote (bearing in mind the toxicity of methionine) is intravenous /V-acetyl-L-cysteine, which, in any case, reaches the liver of the overdosed patient faster. 

Since the introduction of the first cephalosporin antibiotic in 1962, every year several new /1-lactam antibiotics of the cephalosporin-type have reached the market. Continual improvement in the activity spectrum is necessary to overcome resistance phenomena caused by the widespread application of antibiotics. Referring to the hit1 -list of the commercially most successful therapeutics, three /1-lactam antibiotics range among the top twenty. These are cefaclor by E. Lilly, ceftriaxone by Roche, and clavulanic acid as a most efficient /1-lacta-mase inhibitor marketed by Smith Kline-Beecham in combination with the semi-synthetic penicillin derivative amoxicillin under the trade name of Aug-... 

A few years after the introduction of Taxol in 1996, further phytogenic anticancer drugs were launched to treat advanced cancers. Topotecan, marketed by Smith Kline Beecham under the trade name of Hycamtin, was approved by the FDA to treat ovarian cancers that have resisted other chemotherapy drugs. Furthermore, irinotecan was introduced by Pharmacia Upjohn under the trade name of Camptosar for the treatment of metastatic cancer of the colon or rectum. Both compounds are derivatives of camptothecin which was isolated from the Chinese tree Camptotheca acuminata, well known in Chinese Traditional Medicine for anticancer treatment [65]. Isolation of the bioactive principle camptothecin and its structure elucidation had already been performed in 1966... 

Smith Kline Beecham Pharmaceuticals New Frontiers Science Park (North)... 

Division of Pharmacological Sciences, Smith Kline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA... 

Smith Kline Beecham, formerly Smith Kline Beckman. e OTC is over the counter. 

Engerix B (rHBsAg produced in S. cerevisiae) Smith Kline Beecham vaccination against hepatitis B 1998 (US)... 

Twinrix (adult and pediatric formsin EU combination vaccine containing rHBsAg produced in S. cerevisiae as one component) Smith Kline Beecham (EU) and Glaxo Smith Kline (US) immuniTation against hepatitis A and B 1996 (EU, adult), 1997 (EU, pediatric), 2001 (US)... 

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