Leukeran - Chlorambucil

Camptosar- irinotecan Leukeran - chlorambucil Targretin - bexarotene... 

The malignant cells appear to be more susceptible to the effects of the alkylating drugp. Examples of alkylating drag include busulfan (Myleran, Busulfex) and chlorambucil (Leukeran). 

Dennis, age 10 years, has leukemia and is to begin chemotherapy with chlorambucil (Leukeran). Discuss what information would be important to discuss with Dennis and Ms parents before beginning the treatment regimen. 

Davies, I.D., Allanson, J.P., and Causon, R.C. 1999. Rapid determination of the anti-cancer drug chlorambucil (Leukeran) and its phenyl acetic acid mustard metabolite in human serum and plasma by automated solid-phase extraction and liquid chromatography-tandem mass spectrometry. J. Chrom-matogr. B. 732 173. 

Campath was given accelerated approval on the basis of response rate. The pivotal trial was a study in 93 pahents who had been previously treated with an alkylating agent and whose disease had progressed on treatment with fludarabine. The FDA requested a follow-up sfudy for full approval of Campafh by randomizing patients between Campath and chlorambucil (Leukeran) as front-line therapy This trial is ongoing. Thus, Campath has had a convenhonal development approach. 

Chlorambucil is well adsorbed when administered orally. It is used for chronic lymphatic leukemia and for multiple myelomas. Synonyms of this drug are leukeran, amboclorin, and others. 

Chlorambucil (Leukeran) is an aromatic nitrogen mustard that is intermediate in chemical reactivity between mechlorethamine and melphalan. Its mechanisms of action and range of antitumor activity are similar to theirs. It is well absorbed orally, but detailed information concerning its metabolic fate in humans is lacking. 

Chlorambucil (LEUKERAN) 0.1-0.2 mg/kg daily for 3-6 weeks then 2 mg daily for maintenance... 

Chlorambucil Leukeran Chronic lymphocytic leukemia Hodgkin disease non-Hodgkin lymphomas Blood disorders (leukopenia, thrombocytopenia, anemia,] skin rashes/itching pulmonary toxicity seizures... 

A variety of other agents with cytotoxic effects has been used to suppress the immune system. These drugs include chlorambucil (Leukeran), dactinomycin (Cosmegen), mercaptopurine (Purinethol), vinblastine (Velban), and vincristine (Oncovin, Vincasar).41 These... 

Chlorambucil (Leukeran) is the least toxic nitrogen mustard, and is used as the drug of choice in the treatment of chronic lymphocytic leukemia. It is absorbed orally, is slow in its onset of action, and may cause bone marrow depression. 

Alkylating agents interfere with DNA replication and transcription, resulting in depression of T- and/or B-cell populations. The most commonly used alkylating agents in uveitis management include cyclophosphamide (Cytoxan ) and chlorambucil (Leukeran ). 

Significant improvements were achieved with the drugs chlorambucil (Leukeran, 1952) and melphalan (Alkeran, 1954), both developed at the Chester Beatty Laboratory in London. These drugs were more water-soluble (and hence available by mouth rather than intravenous infusion) and more easily taken up by cancer cells. They were also less toxic to bone-marrow cells and have been widely used over the intervening years for the treatment of various leukaemias and other tumours. An interesting combination of the female sex hormone oestradiol with mechlorethamine was invented in Romania in 1966, and was marketed under the trade-name Estracyte (estra-mustine) for the treatment of prostatic cancer. 

Busulfan (Myleran) Carmustine (BCNU) Chlorambucil (Leukeran) Cyclophosphamide (Cytoxan) Hexamethylmelamine (Hexastat)... 

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